Skip to main content
Erschienen in: Brain Structure and Function 5-6/2005

01.12.2005 | Original Article

Computational biology for visualization of brain structure

verfasst von: Arthur W. Toga

Erschienen in: Brain Structure and Function | Ausgabe 5-6/2005

Einloggen, um Zugang zu erhalten

Abstract

The complexity and variability of human brain (as well as other species) across subjects is so great that reliance on maps and atlases is essential to effectively manipulate, analyze and interpret brain data. Central to these tasks is the construction of averages, templates and models to describe how the brain and its component parts are organized. Design of appropriate reference systems and visualization strategies for human brain data presents considerable challenges, since these systems must capture how brain structure and function vary in large populations, across age and gender, in different disease states, across imaging modalities and even across species. This paper will describe the application of brain maps to a variety of questions and problems in health and disease. It includes a brief survey of different types of maps, including those that capture dynamic patterns of brain change over time.
Literatur
Zurück zum Zitat Avoli M, Hwa GC, Kostopoulos G et al (1991) Electrophysiological analysis of human neocortex in vitro: experimental techniques and methodological approaches. Can J Neurol Sci 18:636–639PubMed Avoli M, Hwa GC, Kostopoulos G et al (1991) Electrophysiological analysis of human neocortex in vitro: experimental techniques and methodological approaches. Can J Neurol Sci 18:636–639PubMed
Zurück zum Zitat Bohm C, Greitz T, Kingsley D et al (1983) Adjustable Computerized Brain Atlas for Transmission and Emission Tomography. Am J Neuroradiol 4:731–733PubMed Bohm C, Greitz T, Kingsley D et al (1983) Adjustable Computerized Brain Atlas for Transmission and Emission Tomography. Am J Neuroradiol 4:731–733PubMed
Zurück zum Zitat Brodmann K (1960) Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues, Barth, Leipzig, 1909. In: Some papers on the cerebral cortex, translated as: On the comparative localization of the cortex, Thomas, Springfield, pp 201–230 Brodmann K (1960) Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues, Barth, Leipzig, 1909. In: Some papers on the cerebral cortex, translated as: On the comparative localization of the cortex, Thomas, Springfield, pp 201–230
Zurück zum Zitat Cannestra AF, Santori EM, Holmes CJ et al (1997) A 3D multi-modality brain map of the Nemestrina monkey. Brain Res Bull 43(2):141–148PubMedCrossRef Cannestra AF, Santori EM, Holmes CJ et al (1997) A 3D multi-modality brain map of the Nemestrina monkey. Brain Res Bull 43(2):141–148PubMedCrossRef
Zurück zum Zitat Cannon TD, Thompson PM, van Erp T, Toga AW, Poutanen VP, Huttunen M, Lönnqvist J, Standertskjöld-Nordenstam CG, Narr KL, Khaledy M, Zoumalan CI, Dail R, Kaprio J (2002) Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for Schizophrenia. Proc Natl Acad Sci USA 99(5):3228–3233PubMedCrossRef Cannon TD, Thompson PM, van Erp T, Toga AW, Poutanen VP, Huttunen M, Lönnqvist J, Standertskjöld-Nordenstam CG, Narr KL, Khaledy M, Zoumalan CI, Dail R, Kaprio J (2002) Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for Schizophrenia. Proc Natl Acad Sci USA 99(5):3228–3233PubMedCrossRef
Zurück zum Zitat Christensen GE, Rabbitt RD, Miller MI (1993) A deformable neuroanatomy textbook based on viscous fluid mechanics. In: 27th annual conference on informaion sciences and systems, pp 211–216 Christensen GE, Rabbitt RD, Miller MI (1993) A deformable neuroanatomy textbook based on viscous fluid mechanics. In: 27th annual conference on informaion sciences and systems, pp 211–216
Zurück zum Zitat Christensen GE, Miller MI, Marsh JL et al (1995) Automatic analysis of medical images using a deformable textbook. In: Proceedings of Comparative Assistance in Radiology. Springer, Berlin Heidelberg New York, pp 152–157 Christensen GE, Miller MI, Marsh JL et al (1995) Automatic analysis of medical images using a deformable textbook. In: Proceedings of Comparative Assistance in Radiology. Springer, Berlin Heidelberg New York, pp 152–157
Zurück zum Zitat Christensen GE, Rabbitt RD, Miller MI (1996) Deformable Templates using Large Deformation Kinematics. IEEE Trans Image Process 5(10):1435–1447CrossRefPubMed Christensen GE, Rabbitt RD, Miller MI (1996) Deformable Templates using Large Deformation Kinematics. IEEE Trans Image Process 5(10):1435–1447CrossRefPubMed
Zurück zum Zitat Collins DL, Holmes CJ, Peters TM et al (1995) Automatic 3D Model-Based Neuroanatomical Segmentation. Hum Brain Mapp 3:190–208CrossRef Collins DL, Holmes CJ, Peters TM et al (1995) Automatic 3D Model-Based Neuroanatomical Segmentation. Hum Brain Mapp 3:190–208CrossRef
Zurück zum Zitat Csernansky JG, Joshi S, Wang L et al (1998) Hippocampal morphometry in Schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci USA 95(19):11406–11411PubMedCrossRef Csernansky JG, Joshi S, Wang L et al (1998) Hippocampal morphometry in Schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci USA 95(19):11406–11411PubMedCrossRef
Zurück zum Zitat Csernansky JG, Wang L, Joshi S et al (2000) Early Dementia of the Alzheimer type is distinguished from aging by high-dimensional mapping of the hippocampus. Neurology 55(11):1636–1643PubMed Csernansky JG, Wang L, Joshi S et al (2000) Early Dementia of the Alzheimer type is distinguished from aging by high-dimensional mapping of the hippocampus. Neurology 55(11):1636–1643PubMed
Zurück zum Zitat Damasio H (ed) (1995) Human brain anatomy in computerized images. Oxford University Press, Oxford Damasio H (ed) (1995) Human brain anatomy in computerized images. Oxford University Press, Oxford
Zurück zum Zitat Drury HA, Van Essen DC (1997) Analysis of functional specialization in human cerebral cortex using the visible man surface based atlas. Hum Brain Mapp 5:233–237PubMedCrossRef Drury HA, Van Essen DC (1997) Analysis of functional specialization in human cerebral cortex using the visible man surface based atlas. Hum Brain Mapp 5:233–237PubMedCrossRef
Zurück zum Zitat Duvernoy HM (1991) The human brain. Springer, Berlin Heidelberg New York Duvernoy HM (1991) The human brain. Springer, Berlin Heidelberg New York
Zurück zum Zitat Fischl B, Liu A, Dale AM (2001) Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 20(1):70–80PubMedCrossRef Fischl B, Liu A, Dale AM (2001) Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 20(1):70–80PubMedCrossRef
Zurück zum Zitat Fox PT, Perlmutter JS, Raichle M (1985) A stereotactic method of localization for positron emission tomography. J Comp Assist Tomogr 9(1):141–153CrossRef Fox PT, Perlmutter JS, Raichle M (1985) A stereotactic method of localization for positron emission tomography. J Comp Assist Tomogr 9(1):141–153CrossRef
Zurück zum Zitat Fox PT, Mintun MA, Reiman EM et al (1988) Enhanced detection of focal brain responses using inter-subject averaging and change distribution analysis of subtracted PET images. J Cereb Blood Flow Metab 8:642–653PubMed Fox PT, Mintun MA, Reiman EM et al (1988) Enhanced detection of focal brain responses using inter-subject averaging and change distribution analysis of subtracted PET images. J Cereb Blood Flow Metab 8:642–653PubMed
Zurück zum Zitat Fox NC, Freeborough PA, Rossor MN (1996) Visualization and quantification of rates of cerebral atrophy in Alzheimer’s disease. Lancet 348(9020):94–97PubMedCrossRef Fox NC, Freeborough PA, Rossor MN (1996) Visualization and quantification of rates of cerebral atrophy in Alzheimer’s disease. Lancet 348(9020):94–97PubMedCrossRef
Zurück zum Zitat Freeborough PA, Woods RP, Fox NC (1996) Accurate registration of serial 3D MR brain images and its application to visualizing change in neurodegenerative disorders. J Comput Assist Tomogr 20(6):1012–1022PubMedCrossRef Freeborough PA, Woods RP, Fox NC (1996) Accurate registration of serial 3D MR brain images and its application to visualizing change in neurodegenerative disorders. J Comput Assist Tomogr 20(6):1012–1022PubMedCrossRef
Zurück zum Zitat Friston KJ, Passingham RE, Nutt JG et al (1989) Localization in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab 9:690–695PubMed Friston KJ, Passingham RE, Nutt JG et al (1989) Localization in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab 9:690–695PubMed
Zurück zum Zitat Friston KJ, Frith CD, Liddle PF et al (1991) Plastic transformation of PET images. J Comp Assist Tomogr 9(1):141–153 Friston KJ, Frith CD, Liddle PF et al (1991) Plastic transformation of PET images. J Comp Assist Tomogr 9(1):141–153
Zurück zum Zitat Gee JC, Reivich M, Bajcsy R (1993) Elastically deforming an atlas to match anatomical brain images. J Comp Assist Tomogr 17(2):225–236 Gee JC, Reivich M, Bajcsy R (1993) Elastically deforming an atlas to match anatomical brain images. J Comp Assist Tomogr 17(2):225–236
Zurück zum Zitat Geschwind N, Levitsky W (1968) Human brain: left–right asymmetries in temporal speech region. Science 1968:161–186 Geschwind N, Levitsky W (1968) Human brain: left–right asymmetries in temporal speech region. Science 1968:161–186
Zurück zum Zitat Geyer S, Schleicher A, Zilles K (1997) The somatosensory of man: cytoarchitecture and regional distributions of receptor binding sites. Neuroimage 6(1):27–45PubMedCrossRef Geyer S, Schleicher A, Zilles K (1997) The somatosensory of man: cytoarchitecture and regional distributions of receptor binding sites. Neuroimage 6(1):27–45PubMedCrossRef
Zurück zum Zitat Haney S, Thompson PM, Cloughesy TF et al (2001) Mapping therapeutic response in a patient with malignant glioma. J Comput Assist Tomogr 25(4):529–536PubMedCrossRef Haney S, Thompson PM, Cloughesy TF et al (2001) Mapping therapeutic response in a patient with malignant glioma. J Comput Assist Tomogr 25(4):529–536PubMedCrossRef
Zurück zum Zitat Jacobs RE, Fraser SE (1994) Magnetic resonance microscopy of embryonic cell lineages and movements. Science 263(5147):681–684PubMedCrossRef Jacobs RE, Fraser SE (1994) Magnetic resonance microscopy of embryonic cell lineages and movements. Science 263(5147):681–684PubMedCrossRef
Zurück zum Zitat Kikinis R, Shenton ME, Iosifescu DV et al (1996) A digital brain atlas for surgical planning, model-driven segmentation, and teaching. IEEE Trans Vis Comp Graph 2(3):232–241CrossRef Kikinis R, Shenton ME, Iosifescu DV et al (1996) A digital brain atlas for surgical planning, model-driven segmentation, and teaching. IEEE Trans Vis Comp Graph 2(3):232–241CrossRef
Zurück zum Zitat Le Bihan D (1996) Functional MRI of the brain: principles, applications and limitations. Neuroradiology 23(1):1–5 Le Bihan D (1996) Functional MRI of the brain: principles, applications and limitations. Neuroradiology 23(1):1–5
Zurück zum Zitat Mai J, Assheuer J, Paxinos G (1997) Atlas of the human brain. Academic, New York Mai J, Assheuer J, Paxinos G (1997) Atlas of the human brain. Academic, New York
Zurück zum Zitat Mazziotta JC, Toga AW, Evans AC et al (1995) A probabilistic atlas of the human brain: theory and rationale for its development. Neuroimage 2:89–101PubMedCrossRef Mazziotta JC, Toga AW, Evans AC et al (1995) A probabilistic atlas of the human brain: theory and rationale for its development. Neuroimage 2:89–101PubMedCrossRef
Zurück zum Zitat Mazziotta JC, Toga AW, Evans AC et al (2001a) A probabilistic atlas and reference system for the human brain. J R Soc 356:1293–1322 Mazziotta JC, Toga AW, Evans AC et al (2001a) A probabilistic atlas and reference system for the human brain. J R Soc 356:1293–1322
Zurück zum Zitat Mazziotta J, Toga AW, Evans A, Fox P, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, Holmes C, Collins L, Thompson PM, MacDonald D, Iacoboni M, Schormann T, Amunts K, Palomero-Gallagher N, Geyer S, Parsons L, Narr K, Kabani N, Le Goualher G, Feidler J, Smith K, Boomsma D, Hulshoff H, Cannon T, Kawashima R and Mazoyer B (2001b) A four-dimensional probabilistic atlas of the human brain. J Am Med Inform Assoc 8(5):401–430PubMed Mazziotta J, Toga AW, Evans A, Fox P, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, Holmes C, Collins L, Thompson PM, MacDonald D, Iacoboni M, Schormann T, Amunts K, Palomero-Gallagher N, Geyer S, Parsons L, Narr K, Kabani N, Le Goualher G, Feidler J, Smith K, Boomsma D, Hulshoff H, Cannon T, Kawashima R and Mazoyer B (2001b) A four-dimensional probabilistic atlas of the human brain. J Am Med Inform Assoc 8(5):401–430PubMed
Zurück zum Zitat Mega MS, Chen S, Thompson PM et al (1997) Mapping pathology to metabolism: coregistration of stained whole brain sections to PET in Alzheimer’s disease. NeuroImage 5:147–153PubMedCrossRef Mega MS, Chen S, Thompson PM et al (1997) Mapping pathology to metabolism: coregistration of stained whole brain sections to PET in Alzheimer’s disease. NeuroImage 5:147–153PubMedCrossRef
Zurück zum Zitat Mega MS, Dinov ID, Thompson PM, Manese M, Lindshield C, Moussai J, Tran N, Olsen K, Felix J, Zoumalan C, Woods RP, Toga AW, Mazziotta JC (2004) Automated brain tissue assessment in the elderly and demented population: construction and validation of a sub-volume probabilistic brain atlas. Neuroimage (in press) Mega MS, Dinov ID, Thompson PM, Manese M, Lindshield C, Moussai J, Tran N, Olsen K, Felix J, Zoumalan C, Woods RP, Toga AW, Mazziotta JC (2004) Automated brain tissue assessment in the elderly and demented population: construction and validation of a sub-volume probabilistic brain atlas. Neuroimage (in press)
Zurück zum Zitat Meltzer CC, Frost JJ (1994) Partial volume correction in emission-computed tomography: focus on Alzheimer disease. In: Thatcher RW, Hallett M, Zeffiro T, John ER, Huerta M (eds) Functional neuroimaging: technical foundations. Academic, New York, pp 163–170 Meltzer CC, Frost JJ (1994) Partial volume correction in emission-computed tomography: focus on Alzheimer disease. In: Thatcher RW, Hallett M, Zeffiro T, John ER, Huerta M (eds) Functional neuroimaging: technical foundations. Academic, New York, pp 163–170
Zurück zum Zitat Miller MI, Christensen GE, Amit Y et al (1993) Mathematical textbook of deformable neuroanatomies. Proc Natl Acad Sci USA 90:11944–11948PubMedCrossRef Miller MI, Christensen GE, Amit Y et al (1993) Mathematical textbook of deformable neuroanatomies. Proc Natl Acad Sci USA 90:11944–11948PubMedCrossRef
Zurück zum Zitat Minoshima S, Koeppe RA, Frey KA et al (1994) Stereotactic PET atlas of the human brain: aid for visual interpretation of functional brain images. J Nucl Med 35:949–954PubMed Minoshima S, Koeppe RA, Frey KA et al (1994) Stereotactic PET atlas of the human brain: aid for visual interpretation of functional brain images. J Nucl Med 35:949–954PubMed
Zurück zum Zitat Missir O, Dutheil-Desclercs C, Meder JF et al (1989) Central sulcus patterns at MRI. J Neuroradiol 16:133–144PubMed Missir O, Dutheil-Desclercs C, Meder JF et al (1989) Central sulcus patterns at MRI. J Neuroradiol 16:133–144PubMed
Zurück zum Zitat Ono M, Kubik S, Abernathey CD (1990) Atlas of the cerebral sulci. Thieme, Stuttgart Ono M, Kubik S, Abernathey CD (1990) Atlas of the cerebral sulci. Thieme, Stuttgart
Zurück zum Zitat Palovcik RA, Reid SA, Principe JC et al (1992) 3D computer animation of electrophysiological responses. J Neurosci Methods 41:1–9PubMedCrossRef Palovcik RA, Reid SA, Principe JC et al (1992) 3D computer animation of electrophysiological responses. J Neurosci Methods 41:1–9PubMedCrossRef
Zurück zum Zitat Rademacher J, Caviness VS Jr, Steinmetz H et al (1993) Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping and neurobiology. Cereb Cortex 3(4):313–329PubMedCrossRef Rademacher J, Caviness VS Jr, Steinmetz H et al (1993) Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping and neurobiology. Cereb Cortex 3(4):313–329PubMedCrossRef
Zurück zum Zitat Rajkowska G, Goldman-Rakic P (1995) Cytoarchitectonic definition of pre-frontal areas in the normal human cortex: ii. variability in locations of areas 9 and 46 and relationship to the Talairach coordinate system. Cereb Cortex 5(4):323–337PubMedCrossRef Rajkowska G, Goldman-Rakic P (1995) Cytoarchitectonic definition of pre-frontal areas in the normal human cortex: ii. variability in locations of areas 9 and 46 and relationship to the Talairach coordinate system. Cereb Cortex 5(4):323–337PubMedCrossRef
Zurück zum Zitat Rizzo G, Gilardi MC, Prinster A et al (1995) An elastic computerized brain atlas for the analysis of clinical PET/SPET data. Eur J Nucl Med 22(11):1313–1318PubMedCrossRef Rizzo G, Gilardi MC, Prinster A et al (1995) An elastic computerized brain atlas for the analysis of clinical PET/SPET data. Eur J Nucl Med 22(11):1313–1318PubMedCrossRef
Zurück zum Zitat Roland PE, Zilles K (1994) Brain atlases—a new research tool. Trends Neurosci 17(11):458–467PubMedCrossRef Roland PE, Zilles K (1994) Brain atlases—a new research tool. Trends Neurosci 17(11):458–467PubMedCrossRef
Zurück zum Zitat Smith GE (1907) A new topographical survey of the human cerebral cortex, being an account of the distribution of the anatomically distinct cortical areas and their relationship to the cerebral sulci. J Anat 41:237–254 Smith GE (1907) A new topographical survey of the human cerebral cortex, being an account of the distribution of the anatomically distinct cortical areas and their relationship to the cerebral sulci. J Anat 41:237–254
Zurück zum Zitat Sowell ER, Thompson PM, Rex D, Kornsand D, Tessner KD, Jernigan TL, Toga AW (2002) Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian cortices. Cereb Cortex 12:17–26PubMedCrossRef Sowell ER, Thompson PM, Rex D, Kornsand D, Tessner KD, Jernigan TL, Toga AW (2002) Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian cortices. Cereb Cortex 12:17–26PubMedCrossRef
Zurück zum Zitat Sowell ER, Thompson PM, Peterson BS, Mattson SN, Welcome SE, Henkenius AL, Riley EP, Jernigan TL, Toga AW (2002b) Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure. Neuroimage 17:1807–1819PubMedCrossRef Sowell ER, Thompson PM, Peterson BS, Mattson SN, Welcome SE, Henkenius AL, Riley EP, Jernigan TL, Toga AW (2002b) Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure. Neuroimage 17:1807–1819PubMedCrossRef
Zurück zum Zitat Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL, Toga AW (2003) Mapping cortical change across the human life span. Nat Neurosci 6(3):3019–3315CrossRef Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL, Toga AW (2003) Mapping cortical change across the human life span. Nat Neurosci 6(3):3019–3315CrossRef
Zurück zum Zitat Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS (2003b) Cortical abnormalities in children and adolescents with attention deficit hyperactivity disorder. Lancet 362:1699–1707PubMedCrossRef Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS (2003b) Cortical abnormalities in children and adolescents with attention deficit hyperactivity disorder. Lancet 362:1699–1707PubMedCrossRef
Zurück zum Zitat Steinmetz H, Furst G, Freund H-J (1989) Cerebral cortical localization: application and validation of the proportional grid system in MR imaging. J Comp Assist Tomogr 13(1):10–19 Steinmetz H, Furst G, Freund H-J (1989) Cerebral cortical localization: application and validation of the proportional grid system in MR imaging. J Comp Assist Tomogr 13(1):10–19
Zurück zum Zitat Steinmetz H, Furst G, Freund H-J (1990) Variation of perisylvian and calcarine anatomic landmarks within stereotaxic proportional coordinates. Am J Neuroradiol 11(6):1123–1130PubMed Steinmetz H, Furst G, Freund H-J (1990) Variation of perisylvian and calcarine anatomic landmarks within stereotaxic proportional coordinates. Am J Neuroradiol 11(6):1123–1130PubMed
Zurück zum Zitat Stensaas SS, Eddington DK, Dobelle WH (1974) The topography and variability of the primary visual cortex in man. J Neurosurg 40:747–755PubMedCrossRef Stensaas SS, Eddington DK, Dobelle WH (1974) The topography and variability of the primary visual cortex in man. J Neurosurg 40:747–755PubMedCrossRef
Zurück zum Zitat Subsol G, Roberts N, Doran M et al (1997) Automatic analysis of cerebral atrophy. magn reson imaging 15(8):917–927PubMedCrossRef Subsol G, Roberts N, Doran M et al (1997) Automatic analysis of cerebral atrophy. magn reson imaging 15(8):917–927PubMedCrossRef
Zurück zum Zitat Swanson LW (1992) Brain maps: structure of the rat brain. Elsevier, Amsterdam Swanson LW (1992) Brain maps: structure of the rat brain. Elsevier, Amsterdam
Zurück zum Zitat Talairach J, Szikla G (1967) Atlas d’Anatomie Stereotaxique du Telencephale: Etudes Anatomo-Radiologiques. Masson and Cie, Paris Talairach J, Szikla G (1967) Atlas d’Anatomie Stereotaxique du Telencephale: Etudes Anatomo-Radiologiques. Masson and Cie, Paris
Zurück zum Zitat Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, New York Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, New York
Zurück zum Zitat Thirion J-P, Prima S, Subsol S (1998) Statistical analysis of dissymmetry in volumetric medical images, INRIA Tech Report RR-3178 Thirion J-P, Prima S, Subsol S (1998) Statistical analysis of dissymmetry in volumetric medical images, INRIA Tech Report RR-3178
Zurück zum Zitat Thompson PM, Toga AW (1997) Detection, visualization and animation of abnormal anatomic structure with a deformable probabilistic brain atlas based on random vector field transformations. Med Image Anal 1(4):271–294PubMedCrossRef Thompson PM, Toga AW (1997) Detection, visualization and animation of abnormal anatomic structure with a deformable probabilistic brain atlas based on random vector field transformations. Med Image Anal 1(4):271–294PubMedCrossRef
Zurück zum Zitat Thompson PM, Toga AW (1998) Anatomically-driven strategies for high-dimensional brain image warping and pathology detection. In: Toga AW (ed) Brain warping. Academic, New York Thompson PM, Toga AW (1998) Anatomically-driven strategies for high-dimensional brain image warping and pathology detection. In: Toga AW (ed) Brain warping. Academic, New York
Zurück zum Zitat Thompson PM, Schwartz C, Lin RT et al (1996) 3D statistical analysis of sulcal variability in the human brain. J Neurosci 16(13):4261–4274PubMed Thompson PM, Schwartz C, Lin RT et al (1996) 3D statistical analysis of sulcal variability in the human brain. J Neurosci 16(13):4261–4274PubMed
Zurück zum Zitat Thompson PM, Giedd JN, Woods RP et al (2000a) Growth patterns in the developing brain detected by using continuum-mechanical tensor maps. Nature 404:190–193PubMedCrossRef Thompson PM, Giedd JN, Woods RP et al (2000a) Growth patterns in the developing brain detected by using continuum-mechanical tensor maps. Nature 404:190–193PubMedCrossRef
Zurück zum Zitat Thompson PM, Mega MS, Toga AW (2000b) Disease-specific brain atlases. In: Toga AW, Mazziotta JC (eds) Brain mapping: the disorders. Academic, New York Thompson PM, Mega MS, Toga AW (2000b) Disease-specific brain atlases. In: Toga AW, Mazziotta JC (eds) Brain mapping: the disorders. Academic, New York
Zurück zum Zitat Thompson PM, Mega MS, Toga AW (2000c) Disease-specific probabilistic brain atlases. In: IEEE international conference on computer vision and pattern recognition, pp 227–234 Thompson PM, Mega MS, Toga AW (2000c) Disease-specific probabilistic brain atlases. In: IEEE international conference on computer vision and pattern recognition, pp 227–234
Zurück zum Zitat Thompson PM, Woods RP, Mega MS et al (2000d) Mathematical/computational challenges in creating population-based brain atlases, [invited paper]. Hum Brain Mapp 9(2):81–92PubMedCrossRef Thompson PM, Woods RP, Mega MS et al (2000d) Mathematical/computational challenges in creating population-based brain atlases, [invited paper]. Hum Brain Mapp 9(2):81–92PubMedCrossRef
Zurück zum Zitat Thompson PM, Cannon TD, Narr KL, van Erp T, Poutanen V-P, Hutteunen M, Lönnqvist J, Standertskjöld-Nordenstam C-G, Kaprio J, Khaledy M, Dail R, Zoumalen CI, Toga AW (2001a) Genetic influences on brain structure. Nat Neurosci 4(12):1253–1258PubMedCrossRef Thompson PM, Cannon TD, Narr KL, van Erp T, Poutanen V-P, Hutteunen M, Lönnqvist J, Standertskjöld-Nordenstam C-G, Kaprio J, Khaledy M, Dail R, Zoumalen CI, Toga AW (2001a) Genetic influences on brain structure. Nat Neurosci 4(12):1253–1258PubMedCrossRef
Zurück zum Zitat Thompson PM, Mega MS, Vidal C et al (2001b) Detecting disease-specific patterns of brain structure using cortical pattern matching and a population-based probabilistic brain atlas. In: IEEE conference on information processing in medical imaging (IPMI), UC Davis Thompson PM, Mega MS, Vidal C et al (2001b) Detecting disease-specific patterns of brain structure using cortical pattern matching and a population-based probabilistic brain atlas. In: IEEE conference on information processing in medical imaging (IPMI), UC Davis
Zurück zum Zitat Thompson PM, Mega MS, Woods RP et al (2001c) Early cortical change in Alzheimer’s disease detected with a disease-specific population-based brain atlas. Cereb Cortex 11(1):1–16PubMedCrossRef Thompson PM, Mega MS, Woods RP et al (2001c) Early cortical change in Alzheimer’s disease detected with a disease-specific population-based brain atlas. Cereb Cortex 11(1):1–16PubMedCrossRef
Zurück zum Zitat Thompson PM, Vidal C, Giedd JN, Gochman P, Blumenthal J, Nicolson R, Toga AW, Rapoport JL (2001d). Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset Schizophrenia. In: Proceedings of the National Academy of Sciences of the USA 98(20):11650–11655, 25 September 2001 Thompson PM, Vidal C, Giedd JN, Gochman P, Blumenthal J, Nicolson R, Toga AW, Rapoport JL (2001d). Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset Schizophrenia. In: Proceedings of the National Academy of Sciences of the USA 98(20):11650–11655, 25 September 2001
Zurück zum Zitat Thompson PM, Rapport JL, Cannon TD, Toga AW (2002) Imaging the brain as schizophrenia develops: dynamic and genetic brain maps. Prim Psychiatry 9(11):40–47PubMed Thompson PM, Rapport JL, Cannon TD, Toga AW (2002) Imaging the brain as schizophrenia develops: dynamic and genetic brain maps. Prim Psychiatry 9(11):40–47PubMed
Zurück zum Zitat Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, Herman D, Hong MS, Dittmer SS, Doddrell DM, Toga AW (2003) Dynamics of gray matter loss in Alzheimer’s disease. J Neurosci 23(3):994–1005PubMed Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, Herman D, Hong MS, Dittmer SS, Doddrell DM, Toga AW (2003) Dynamics of gray matter loss in Alzheimer’s disease. J Neurosci 23(3):994–1005PubMed
Zurück zum Zitat Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, Lee JY, Toga AW, Ling W, London ED (2004). Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 24(26):6028–6036, 30 June 2004 Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, Lee JY, Toga AW, Ling W, London ED (2004). Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 24(26):6028–6036, 30 June 2004
Zurück zum Zitat Toga AW (1998) Brain warping. Academic, New York Toga AW (1998) Brain warping. Academic, New York
Zurück zum Zitat Toga AW, Ambach K, Quinn B et al (1994) Postmortem anatomy from cryosectioned whole human brain. J Neurosci Methods 54(2):239–252PubMedCrossRef Toga AW, Ambach K, Quinn B et al (1994) Postmortem anatomy from cryosectioned whole human brain. J Neurosci Methods 54(2):239–252PubMedCrossRef
Zurück zum Zitat Toga AW, Thompson PM, Payne BA (1996) Modeling morphometric changes of the brain during development. In: Thatcher RW, Lyon GR, Rumsey J, Krasnegor N (eds) Developmental neuroimaging: mapping the development of brain and behavior. Academic, New York Toga AW, Thompson PM, Payne BA (1996) Modeling morphometric changes of the brain during development. In: Thatcher RW, Lyon GR, Rumsey J, Krasnegor N (eds) Developmental neuroimaging: mapping the development of brain and behavior. Academic, New York
Zurück zum Zitat Van Essen DC, Maunsell JHR (1983) Hierarchical organization an functional streams in the visual cortex. Trends Neurol Sci 6:370–375CrossRef Van Essen DC, Maunsell JHR (1983) Hierarchical organization an functional streams in the visual cortex. Trends Neurol Sci 6:370–375CrossRef
Zurück zum Zitat Watson JDG, Myers R, Frackowiak RSJ et al (1993) Area V5 of the human brain: evidence form a combined study using positron emission tomography and magnetic resonance imaging. Cereb Cortex 3:79–94PubMedCrossRef Watson JDG, Myers R, Frackowiak RSJ et al (1993) Area V5 of the human brain: evidence form a combined study using positron emission tomography and magnetic resonance imaging. Cereb Cortex 3:79–94PubMedCrossRef
Zurück zum Zitat Woods RP (1996) Modeling for intergroup comparisons of imaging data. Neuroimage 4(3):84–94CrossRef Woods RP (1996) Modeling for intergroup comparisons of imaging data. Neuroimage 4(3):84–94CrossRef
Zurück zum Zitat Zeineh MM, Engel SA, Thompson PM et al (2001) Unfolding the human hippocampus with high-resolution structural and functional mri [invited paper]. New Anat 265(2):111–120CrossRef Zeineh MM, Engel SA, Thompson PM et al (2001) Unfolding the human hippocampus with high-resolution structural and functional mri [invited paper]. New Anat 265(2):111–120CrossRef
Metadaten
Titel
Computational biology for visualization of brain structure
verfasst von
Arthur W. Toga
Publikationsdatum
01.12.2005
Verlag
Springer-Verlag
Erschienen in
Brain Structure and Function / Ausgabe 5-6/2005
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-005-0040-6

Weitere Artikel der Ausgabe 5-6/2005

Brain Structure and Function 5-6/2005 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.