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European Journal of Nuclear Medicine and Molecular Imaging

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01.11.2015 | Editorial Commentary

Concerning pretreatment ¹⁸F-FDG PET/CT imaging in patients with large or locally advanced breast cancer

verfasst von: David Groheux, Elif Hindié

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 12/2015

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In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, García Vicente and colleagues report on the role of ¹⁸F-FDG PET/CT in patients with clinical stage II or III breast cancer (BC). Following PET/CT imaging, the new metabolic stage was stage IV in 38 out of 198 patients (19 %). This had a major prognostic impact. The hazard ratio for death from BC (overall survival) was 0.117 for stage II vs. metabolic stage IV and 0.28 for stage III vs. metabolic stage IV [1]. Although the title of the study refers to locally advanced BC, about half of the included patients had clinical stage II disease [1]. Locally advanced BC is variably defined in the literature; some recommendations such as that of the National Comprehensive Cancer Network refers to patients with N2, N3 or T4 disease, i.e. AJCC clinical stages IIIA (excluding T3N1), IIIB and IIIC (Table 1) [2, 3].

Table 1

TNM stage grouping for breast cancer according to the AJCC Cancer Staging Manual [3]

AJCC stage	TNM			NCCN
I	T1	N0	M0	Primary operable breast cancer
IIA	T0	N1	M0
	T1	N1	M0
	T2	N0	M0
IIB	T2	N1	M0
IIB	T3	N0	M0
IIIA	T3	N1	M0
	T0	N2	M0	Locally advanced breast cancer
	T1	N2	M0
	T2	N2	M0
	T3	N2	M0
IIIB	T4	N0	M0
	T4	N1	M0
	T4	N2	M0
IIIC	Any T	N3	M0
IV	Any T	Any N	M1	Metastatic disease

AJCC American Joint Committee on Cancer, TNM Tumor Nodes Metastasis classification, NCCN National Comprehensive Cancer Network

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Titel: Concerning pretreatment 18F-FDG PET/CT imaging in patients with large or locally advanced breast cancer
verfasst von: David Groheux
Elif Hindié
Publikationsdatum: 01.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 12/2015
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3144-0

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