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01.06.2009

Concordant colon tumors in monozygotic twins previously treated for prostate cancer

verfasst von: Arnoud Templeton, Giancarlo Marra, Emanuele Valtorta, Karl Heinimann, Hansjakob Müller, Dieter Köberle, Silke Gillessen

Erschienen in: Familial Cancer | Ausgabe 2/2009

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Abstract

This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.

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Titel: Concordant colon tumors in monozygotic twins previously treated for prostate cancer
verfasst von: Arnoud Templeton
Giancarlo Marra
Emanuele Valtorta
Karl Heinimann
Hansjakob Müller
Dieter Köberle
Silke Gillessen
Publikationsdatum: 01.06.2009
Verlag: Springer Netherlands
Erschienen in: Familial Cancer / Ausgabe 2/2009
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI: https://doi.org/10.1007/s10689-008-9222-8

Springer Medizin

Concordant colon tumors in monozygotic twins previously treated for prostate cancer

Abstract

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Springer Medizin

Abstract

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