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Familial Cancer

Familial Cancer OnlineFirst articles

27.02.2020 | Original Article

Do the risks of Lynch syndrome-related cancers depend on the parent of origin of the mutation?

Individuals who carry pathogenic mutations in DNA mismatch repair (MMR) genes have high risks of cancer, and small studies have suggested that these risks depend on the sex of the parent from whom the mutation was inherited. We have conducted the …

24.02.2020 | Original Article

Perceptions of risk and reward in BRCA1 and BRCA2 mutation carriers choosing salpingectomy for ovarian cancer prevention

Salpingectomy with interval oophorectomy has gained traction as an ovarian cancer prevention strategy, but is not currently recommended for high risk women. Nevertheless, some choose this approach. We aimed to understand risk perception and plans …

22.02.2020 | Original Article Open Access

Increased prevalence of Barrett’s esophagus in patients with MUTYH-associated polyposis (MAP)

Barrett’s oesophagus (BE) has been associated with an increased risk of both colorectal adenomas and colorectal cancer. A recent investigation reported a high frequency of BE in patients with adenomatous polyposis coli (APC)-associated polyposis …

14.02.2020 | Short Communication

Mismatch repair gene pathogenic germline variants in a population-based cohort of breast cancer

The advent of gene panel testing is challenging the previous practice of using clinically defined cancer family syndromes to inform single-gene genetic screening. Individual and family cancer histories that would have previously indicated testing …

12.02.2020 | Short Communication

Co-occurrence of multiple endocrine neoplasia type 4 and spinal neurofibromatosis: a case report

Multiple Endocrine Neoplasia (MEN) type 4 is a rare genetic condition that results from variants of the CDKN1B gene and predisposes individuals to develop endocrine tumors. Spinal neurofibromatosis (SNF) is an uncommon subtype of neurofibromatosis …

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Über diese Zeitschrift

Clinical cancer genetics has now matured to a truly multidisciplinary medical discipline in which clinical and molecular geneticists work with clinical and medical oncologists as well as with psycho-social workers.

Due to the multidisciplinary nature of clinical cancer genetics most papers are currently being published in a wide variety of journals on epidemiology, oncology and genetics. Familial Cancer provides a forum bringing these topics together, focusing on the interests and needs of the clinician.

The journal concentrates on clinical cancer genetics. Most major areas in the field are included, such as epidemiology of familial cancer, molecular analysis and diagnosis, clinical expression, treatment and prevention, counseling and the health economics of familial cancer.

Familial Cancer publishes Original Articles, Reviews, Short Communications, Book Reviews, and Letters to the Editor.

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