Erschienen in:
01.04.2014 | Case Report
Concurrent presentation of nodal myeloid sarcoma and bone marrow chronic lymphocytic leukemia/small lymphocytic lymphoma: a unique association
verfasst von:
Vasilios Perifanis, Michael D. Diamantidis, Kyriaki Chalvatzi, Vassiliki Kaloutsi, Dimitra Markala, Virginia Voulgaridou, Pavlina Pantelidou, Athinodoros Pavlidis, George Stavrou, Georgia Kaiafa
Erschienen in:
International Journal of Hematology
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Ausgabe 4/2014
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Abstract
Myeloid sarcoma (MS), previously known as granulocytic sarcoma, is a rare, localized, tumor mass composed of myeloid precursor cells, with or without maturation, and occurring at an anatomical site other than the bone marrow (BM). Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), in contrast, is a B-cell hematological malignancy. We describe the first reported case of concurrent presentation of nodal MS and of BM CLL/SLL in the same patient. Fatal leukemic central nervous system infiltration was the final outcome. We provide possible explanations and investigate the pathophysiology of this unique, previously unreported co-morbidity.