Skip to main content
Erschienen in: Pediatric Radiology 12/2021

12.05.2021 | Contrast-enhanced ultrasound (CEUS) in children

Contrast-enhanced ultrasound of the pediatric bowel

verfasst von: Ami Gokli, Jonathan R. Dillman, Paul D. Humphries, Damjana Ključevšek, Hans-Joachim Mentzel, Erika Rubesova, Marcelo S. Takahashi, Sudha A. Anupindi

Erschienen in: Pediatric Radiology | Ausgabe 12/2021

Einloggen, um Zugang zu erhalten

Abstract

Contrast-enhanced ultrasound (CEUS) has emerged as a valuable modality for bowel imaging in adults and children. CEUS enables visualization of the perfusion of the bowel wall and of the associated mesentery in healthy and disease states. In addition, CEUS images can be used to make quantitative measurements of contrast kinetics, allowing for objective assessment of bowel wall enhancement. Bowel CEUS is commonly applied to evaluate inflammatory bowel disease and to monitor treatment response. It has also been applied to evaluate necrotizing enterocolitis, intussusception, appendicitis and epiploic appendagitis, although experience with these applications is more limited. In this review article, we present the current experience using CEUS to evaluate the pediatric bowel with emphasis on inflammatory bowel disease, extrapolating the established experience from adult studies. We also discuss emerging applications of CEUS as an adjunct or problem-solving tool for evaluating bowel perfusion.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Medellin A, Merrill C, Wilson SR (2018) Role of contrast-enhanced ultrasound in evaluation of the bowel. Abdom Radiol 43:918–933CrossRef Medellin A, Merrill C, Wilson SR (2018) Role of contrast-enhanced ultrasound in evaluation of the bowel. Abdom Radiol 43:918–933CrossRef
2.
Zurück zum Zitat Pecere S, Holleran G, Ainora ME et al (2018) Usefulness of contrast-enhanced ultrasound (CEUS) in inflammatory bowel disease (IBD). Dig Liver Dis 50:761–767PubMedCrossRef Pecere S, Holleran G, Ainora ME et al (2018) Usefulness of contrast-enhanced ultrasound (CEUS) in inflammatory bowel disease (IBD). Dig Liver Dis 50:761–767PubMedCrossRef
3.
Zurück zum Zitat Ripolles T, Martinez-Perez MJ, Blanc E et al (2011) Contrast-enhanced ultrasound (CEUS) in Crohn's disease: technique, image interpretation and clinical applications. Insights Imaging 2:639–652PubMedPubMedCentralCrossRef Ripolles T, Martinez-Perez MJ, Blanc E et al (2011) Contrast-enhanced ultrasound (CEUS) in Crohn's disease: technique, image interpretation and clinical applications. Insights Imaging 2:639–652PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Serafin Z, Bialecki M, Bialecka A et al (2016) Contrast-enhanced ultrasound for detection of Crohn's disease activity: systematic review and meta-analysis. J Crohns Colitis 10:354–362PubMedCrossRef Serafin Z, Bialecki M, Bialecka A et al (2016) Contrast-enhanced ultrasound for detection of Crohn's disease activity: systematic review and meta-analysis. J Crohns Colitis 10:354–362PubMedCrossRef
5.
Zurück zum Zitat Ma X, Li Y, Jia H et al (2015) Contrast-enhanced ultrasound in the diagnosis of patients suspected of having active Crohn's disease: meta-analysis. Ultrasound Med Biol 41:659–668PubMedCrossRef Ma X, Li Y, Jia H et al (2015) Contrast-enhanced ultrasound in the diagnosis of patients suspected of having active Crohn's disease: meta-analysis. Ultrasound Med Biol 41:659–668PubMedCrossRef
6.
Zurück zum Zitat Incesu L, Yazicioglu AK, Selcuk MB, Ozen N (2004) Contrast-enhanced power Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 50:201–209PubMedCrossRef Incesu L, Yazicioglu AK, Selcuk MB, Ozen N (2004) Contrast-enhanced power Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 50:201–209PubMedCrossRef
7.
Zurück zum Zitat Gorg C, Egbring J, Bert T (2009) Contrast-enhanced ultrasound of epiploic appendagitis. Ultraschall Med 30:163–167PubMedCrossRef Gorg C, Egbring J, Bert T (2009) Contrast-enhanced ultrasound of epiploic appendagitis. Ultraschall Med 30:163–167PubMedCrossRef
8.
Zurück zum Zitat Rafailidis V, Phillips C, Yusuf G, Sidhu P (2017) A case of adult intussusception with greyscale, contrast-enhanced ultrasound and computerised tomography correlation. Ultrasound 25:120–125PubMedCrossRef Rafailidis V, Phillips C, Yusuf G, Sidhu P (2017) A case of adult intussusception with greyscale, contrast-enhanced ultrasound and computerised tomography correlation. Ultrasound 25:120–125PubMedCrossRef
9.
Zurück zum Zitat Mudambi K, Sandberg J, Bass D, Rubesova E (2020) Contrast enhanced ultrasound: comparing a novel modality to MRI to assess for bowel disease in pediatric Crohn's patients. Transl Gastroenterol Hepatol 5:13PubMedPubMedCentralCrossRef Mudambi K, Sandberg J, Bass D, Rubesova E (2020) Contrast enhanced ultrasound: comparing a novel modality to MRI to assess for bowel disease in pediatric Crohn's patients. Transl Gastroenterol Hepatol 5:13PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Benjamin JL, Dennis R, White S Jr et al (2020) Improved diagnostic sensitivity of bowel disease of prematurity on contrast-enhanced ultrasound. J Ultrasound Med 39:1031–1036PubMedCrossRef Benjamin JL, Dennis R, White S Jr et al (2020) Improved diagnostic sensitivity of bowel disease of prematurity on contrast-enhanced ultrasound. J Ultrasound Med 39:1031–1036PubMedCrossRef
11.
Zurück zum Zitat Thimm MA, Cuffari C, Garcia A et al (2019) Contrast-enhanced ultrasound and shear wave elastography evaluation of Crohn's disease activity in three adolescent patients. Pediatr Gastroenterol Hepatol Nutr 22:282–290PubMedPubMedCentralCrossRef Thimm MA, Cuffari C, Garcia A et al (2019) Contrast-enhanced ultrasound and shear wave elastography evaluation of Crohn's disease activity in three adolescent patients. Pediatr Gastroenterol Hepatol Nutr 22:282–290PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Kljucevsek D, Vidmar D, Urlep D, Dezman R (2016) Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn's disease activity in childhood. Radiol Oncol 50:347–354PubMedPubMedCentralCrossRef Kljucevsek D, Vidmar D, Urlep D, Dezman R (2016) Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn's disease activity in childhood. Radiol Oncol 50:347–354PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Zezos P, Zittan E, Islam S et al (2019) Associations between quantitative evaluation of bowel wall microvascular flow by contrast-enhanced ultrasound and indices of disease activity in Crohn's disease patients using both bolus and infusion techniques. J Clin Ultrasound 47:453–460PubMedCrossRef Zezos P, Zittan E, Islam S et al (2019) Associations between quantitative evaluation of bowel wall microvascular flow by contrast-enhanced ultrasound and indices of disease activity in Crohn's disease patients using both bolus and infusion techniques. J Clin Ultrasound 47:453–460PubMedCrossRef
14.
Zurück zum Zitat Martinez MJ, Ripolles T, Paredes JM et al (2019) Intravenous contrast-enhanced ultrasound for assessing and grading postoperative recurrence of Crohn's disease. Dig Dis Sci 64:1640–1650PubMedCrossRef Martinez MJ, Ripolles T, Paredes JM et al (2019) Intravenous contrast-enhanced ultrasound for assessing and grading postoperative recurrence of Crohn's disease. Dig Dis Sci 64:1640–1650PubMedCrossRef
15.
Zurück zum Zitat Wilkens R, Hagemann-Madsen RH, Peters DA et al (2018) Validity of contrast-enhanced ultrasonography and dynamic contrast-enhanced MR enterography in the assessment of transmural activity and fibrosis in Crohn's disease. J Crohns Colitis 12:48–56PubMedCrossRef Wilkens R, Hagemann-Madsen RH, Peters DA et al (2018) Validity of contrast-enhanced ultrasonography and dynamic contrast-enhanced MR enterography in the assessment of transmural activity and fibrosis in Crohn's disease. J Crohns Colitis 12:48–56PubMedCrossRef
16.
Zurück zum Zitat Goertz RS, Klett D, Wildner D et al (2018) Quantitative contrast-enhanced ultrasound for monitoring vedolizumab therapy in inflammatory bowel disease patients: a pilot study. Acta Radiol 59:1149–1156PubMedCrossRef Goertz RS, Klett D, Wildner D et al (2018) Quantitative contrast-enhanced ultrasound for monitoring vedolizumab therapy in inflammatory bowel disease patients: a pilot study. Acta Radiol 59:1149–1156PubMedCrossRef
17.
Zurück zum Zitat Giannetti A, Matergi M, Biscontri M, Franci L (2017) Contrast-enhanced ultrasonography in clinical practice in Crohn's disease: feasibility of destruction/replenishment method and software analysis. J Ultrasound 20:309–319PubMedPubMedCentralCrossRef Giannetti A, Matergi M, Biscontri M, Franci L (2017) Contrast-enhanced ultrasonography in clinical practice in Crohn's disease: feasibility of destruction/replenishment method and software analysis. J Ultrasound 20:309–319PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Coelho R, Ribeiro H, Maconi G (2017) Bowel thickening in Crohn's disease: fibrosis or inflammation? Diagnostic ultrasound imaging tools. Inflamm Bowel Dis 23:23–34PubMedCrossRef Coelho R, Ribeiro H, Maconi G (2017) Bowel thickening in Crohn's disease: fibrosis or inflammation? Diagnostic ultrasound imaging tools. Inflamm Bowel Dis 23:23–34PubMedCrossRef
19.
Zurück zum Zitat Quaia E, Cabibbo B, De Paoli L et al (2013) The value of time-intensity curves obtained after microbubble contrast agent injection to discriminate responders from non-responders to anti-inflammatory medication among patients with Crohn's disease. Eur Radiol 23:1650–1659PubMedCrossRef Quaia E, Cabibbo B, De Paoli L et al (2013) The value of time-intensity curves obtained after microbubble contrast agent injection to discriminate responders from non-responders to anti-inflammatory medication among patients with Crohn's disease. Eur Radiol 23:1650–1659PubMedCrossRef
20.
Zurück zum Zitat Liu C, Xu XR, Xu HX et al (2015) Conventional ultrasound and contrast-enhanced ultrasound in evaluating the severity of Crohn's disease. Int J Clin Exp Med 8:123–134PubMedPubMedCentral Liu C, Xu XR, Xu HX et al (2015) Conventional ultrasound and contrast-enhanced ultrasound in evaluating the severity of Crohn's disease. Int J Clin Exp Med 8:123–134PubMedPubMedCentral
21.
Zurück zum Zitat Nylund K, Jirik R, Mezl M et al (2013) Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn's disease. Ultrasound Med Biol 39:1197–1206PubMedCrossRef Nylund K, Jirik R, Mezl M et al (2013) Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn's disease. Ultrasound Med Biol 39:1197–1206PubMedCrossRef
22.
Zurück zum Zitat Romanini L, Passamonti M, Navarria M et al (2014) Quantitative analysis of contrast-enhanced ultrasonography of the bowel wall can predict disease activity in inflammatory bowel disease. Eur J Radiol 83:1317–1323PubMedCrossRef Romanini L, Passamonti M, Navarria M et al (2014) Quantitative analysis of contrast-enhanced ultrasonography of the bowel wall can predict disease activity in inflammatory bowel disease. Eur J Radiol 83:1317–1323PubMedCrossRef
23.
Zurück zum Zitat Saevik F, Nylund K, Hausken T et al (2014) Bowel perfusion measured with dynamic contrast-enhanced ultrasound predicts treatment outcome in patients with Crohn's disease. Inflamm Bowel Dis 20:2029–2037PubMedCrossRef Saevik F, Nylund K, Hausken T et al (2014) Bowel perfusion measured with dynamic contrast-enhanced ultrasound predicts treatment outcome in patients with Crohn's disease. Inflamm Bowel Dis 20:2029–2037PubMedCrossRef
24.
Zurück zum Zitat Wong DD, Forbes GM, Zelesco M et al (2012) Crohn's disease activity: quantitative contrast-enhanced ultrasound assessment. Abdom Imaging 37:369–376PubMedCrossRef Wong DD, Forbes GM, Zelesco M et al (2012) Crohn's disease activity: quantitative contrast-enhanced ultrasound assessment. Abdom Imaging 37:369–376PubMedCrossRef
25.
Zurück zum Zitat Ripolles T, Martinez-Perez MJ, Paredes JM et al (2013) Contrast-enhanced ultrasound in the differentiation between phlegmon and abscess in Crohn's disease and other abdominal conditions. Eur J Radiol 82:e525–e531PubMedCrossRef Ripolles T, Martinez-Perez MJ, Paredes JM et al (2013) Contrast-enhanced ultrasound in the differentiation between phlegmon and abscess in Crohn's disease and other abdominal conditions. Eur J Radiol 82:e525–e531PubMedCrossRef
26.
Zurück zum Zitat Mao R, Chen YJ, Chen BL et al (2018) Intra-cavitary contrast-enhanced ultrasound: a novel radiation-free method to detect abscess associated penetrating disease in Crohn's disease. J Crohns Colitis 13:593–599CrossRef Mao R, Chen YJ, Chen BL et al (2018) Intra-cavitary contrast-enhanced ultrasound: a novel radiation-free method to detect abscess associated penetrating disease in Crohn's disease. J Crohns Colitis 13:593–599CrossRef
27.
Zurück zum Zitat Kljucevsek D, Riccabona M, Ording Muller LS et al (2020) Intracavitary contrast-enhanced ultrasonography in children: review with procedural recommendations and clinical applications from the European Society of Paediatric Radiology abdominal imaging task force. Pediatr Radiol 50:596–606PubMedCrossRef Kljucevsek D, Riccabona M, Ording Muller LS et al (2020) Intracavitary contrast-enhanced ultrasonography in children: review with procedural recommendations and clinical applications from the European Society of Paediatric Radiology abdominal imaging task force. Pediatr Radiol 50:596–606PubMedCrossRef
28.
Zurück zum Zitat Menozzi G, Maccabruni V, Zanichelli M, Massari M (2014) Contrast-enhanced ultrasound appearance of primary epiploic appendagitis. J Ultrasound 17:75–76PubMedPubMedCentralCrossRef Menozzi G, Maccabruni V, Zanichelli M, Massari M (2014) Contrast-enhanced ultrasound appearance of primary epiploic appendagitis. J Ultrasound 17:75–76PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Atkinson NSS, Bryant RV, Dong Y et al (2017) How to perform gastrointestinal ultrasound: anatomy and normal findings. World J Gastroenterol 23:6931–6941PubMedPubMedCentralCrossRef Atkinson NSS, Bryant RV, Dong Y et al (2017) How to perform gastrointestinal ultrasound: anatomy and normal findings. World J Gastroenterol 23:6931–6941PubMedPubMedCentralCrossRef
30.
31.
Zurück zum Zitat Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef
32.
Zurück zum Zitat Ripolles T, Martinez-Perez MJ, Paredes JM et al (2019) The role of intravenous contrast agent in the sonographic assessment of Crohn's disease activity: is contrast agent injection necessary? J Crohns Colitis 13:585–592PubMedCrossRef Ripolles T, Martinez-Perez MJ, Paredes JM et al (2019) The role of intravenous contrast agent in the sonographic assessment of Crohn's disease activity: is contrast agent injection necessary? J Crohns Colitis 13:585–592PubMedCrossRef
33.
Zurück zum Zitat Wilkens R, Wilson A, Burns PN et al (2018) Persistent enhancement on contrast-enhanced ultrasound studies of severe Crohn's disease: stuck bubbles? Ultrasound Med Biol 44:2189–2198PubMedCrossRef Wilkens R, Wilson A, Burns PN et al (2018) Persistent enhancement on contrast-enhanced ultrasound studies of severe Crohn's disease: stuck bubbles? Ultrasound Med Biol 44:2189–2198PubMedCrossRef
34.
Zurück zum Zitat Bialecki M, Bialecka A, Laskowska K et al (2014) Contrast-enhanced ultrasonography for the determination of Crohn's disease activity — preliminary experience. Pol J Radiol 79:70–74 Bialecki M, Bialecka A, Laskowska K et al (2014) Contrast-enhanced ultrasonography for the determination of Crohn's disease activity — preliminary experience. Pol J Radiol 79:70–74
35.
Zurück zum Zitat Ripolles T, Rausell N, Paredes JM et al (2013) Effectiveness of contrast-enhanced ultrasound for characterisation of intestinal inflammation in Crohn's disease: a comparison with surgical histopathology analysis. J Crohns Colitis 7:120–128PubMedCrossRef Ripolles T, Rausell N, Paredes JM et al (2013) Effectiveness of contrast-enhanced ultrasound for characterisation of intestinal inflammation in Crohn's disease: a comparison with surgical histopathology analysis. J Crohns Colitis 7:120–128PubMedCrossRef
36.
Zurück zum Zitat Quaia E (2013) Contrast-enhanced ultrasound of the small bowel in Crohn's disease. Abdom Imaging 38:1005–1013PubMedCrossRef Quaia E (2013) Contrast-enhanced ultrasound of the small bowel in Crohn's disease. Abdom Imaging 38:1005–1013PubMedCrossRef
37.
Zurück zum Zitat Paredes JM, Ripolles T, Cortes X et al (2013) Contrast-enhanced ultrasonography: usefulness in the assessment of postoperative recurrence of Crohn's disease. J Crohns Colitis 7:192–201PubMedCrossRef Paredes JM, Ripolles T, Cortes X et al (2013) Contrast-enhanced ultrasonography: usefulness in the assessment of postoperative recurrence of Crohn's disease. J Crohns Colitis 7:192–201PubMedCrossRef
38.
Zurück zum Zitat Ripolles T, Martinez MJ, Paredes JM et al (2009) Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy. Radiology 253:241–248PubMedCrossRef Ripolles T, Martinez MJ, Paredes JM et al (2009) Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy. Radiology 253:241–248PubMedCrossRef
39.
Zurück zum Zitat Migaleddu V, Scanu AM, Quaia E et al (2009) Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology 137:43–52PubMedCrossRef Migaleddu V, Scanu AM, Quaia E et al (2009) Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology 137:43–52PubMedCrossRef
40.
Zurück zum Zitat Quaia E, Gennari AG, Cova MA, van Beek EJR (2018) Differentiation of inflammatory from fibrotic ileal strictures among patients with Crohn's disease based on visual analysis: feasibility study combining conventional B-mode ultrasound, contrast-enhanced ultrasound and strain elastography. Ultrasound Med Biol 44:762–770PubMedCrossRef Quaia E, Gennari AG, Cova MA, van Beek EJR (2018) Differentiation of inflammatory from fibrotic ileal strictures among patients with Crohn's disease based on visual analysis: feasibility study combining conventional B-mode ultrasound, contrast-enhanced ultrasound and strain elastography. Ultrasound Med Biol 44:762–770PubMedCrossRef
41.
Zurück zum Zitat Braden B, Ignee A, Hocke M et al (2010) Diagnostic value and clinical utility of contrast enhanced ultrasound in intestinal diseases. Dig Liver Dis 42:667–674PubMedCrossRef Braden B, Ignee A, Hocke M et al (2010) Diagnostic value and clinical utility of contrast enhanced ultrasound in intestinal diseases. Dig Liver Dis 42:667–674PubMedCrossRef
42.
Zurück zum Zitat Serra C, Menozzi G, Labate AM et al (2007) Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. Eur J Radiol 62:114–121PubMedCrossRef Serra C, Menozzi G, Labate AM et al (2007) Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. Eur J Radiol 62:114–121PubMedCrossRef
43.
Zurück zum Zitat De Pascale A, Garofalo G, Perna M et al (2006) Contrast-enhanced ultrasonography in Crohn's disease. Radiol Med 111:539–550PubMedCrossRef De Pascale A, Garofalo G, Perna M et al (2006) Contrast-enhanced ultrasonography in Crohn's disease. Radiol Med 111:539–550PubMedCrossRef
44.
Zurück zum Zitat Robotti D, Cammarota T, Debani P et al (2004) Activity of Crohn disease: value of color-power-Doppler and contrast-enhanced ultrasonography. Abdom Imaging 29:648–652PubMedCrossRef Robotti D, Cammarota T, Debani P et al (2004) Activity of Crohn disease: value of color-power-Doppler and contrast-enhanced ultrasonography. Abdom Imaging 29:648–652PubMedCrossRef
45.
Zurück zum Zitat Piscaglia F, Nolsoe C, Dietrich CF et al (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 33:33–59PubMedCrossRef Piscaglia F, Nolsoe C, Dietrich CF et al (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 33:33–59PubMedCrossRef
46.
Zurück zum Zitat Campani R, Calliada F, Bottinelli O et al (1998) Contrast enhancing agents in ultrasonography: clinical applications. Eur J Radiol 27:S161–S170PubMedCrossRef Campani R, Calliada F, Bottinelli O et al (1998) Contrast enhancing agents in ultrasonography: clinical applications. Eur J Radiol 27:S161–S170PubMedCrossRef
47.
Zurück zum Zitat van Wassenaer EA, de Voogd FAE, van Rijn RR et al (2020) Bowel ultrasound measurements in healthy children — systematic review and meta-analysis. Pediatr Radiol 50:501–508PubMedCrossRef van Wassenaer EA, de Voogd FAE, van Rijn RR et al (2020) Bowel ultrasound measurements in healthy children — systematic review and meta-analysis. Pediatr Radiol 50:501–508PubMedCrossRef
48.
Zurück zum Zitat Chiorean L, Schreiber-Dietrich D, Braden B et al (2014) Transabdominal ultrasound for standardized measurement of bowel wall thickness in normal children and those with Crohn's disease. Med Ultrason 16:319–324PubMed Chiorean L, Schreiber-Dietrich D, Braden B et al (2014) Transabdominal ultrasound for standardized measurement of bowel wall thickness in normal children and those with Crohn's disease. Med Ultrason 16:319–324PubMed
49.
Zurück zum Zitat Quaia E, Migaleddu V, Baratella E et al (2009) The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment. Eur J Radiol 69:438–444PubMedCrossRef Quaia E, Migaleddu V, Baratella E et al (2009) The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment. Eur J Radiol 69:438–444PubMedCrossRef
50.
Zurück zum Zitat Ponder A, Long MD (2013) A clinical review of recent findings in the epidemiology of inflammatory bowel disease. Clin Epidemiol 5:237–247PubMedPubMedCentral Ponder A, Long MD (2013) A clinical review of recent findings in the epidemiology of inflammatory bowel disease. Clin Epidemiol 5:237–247PubMedPubMedCentral
52.
Zurück zum Zitat Quaia E, De Paoli L, Stocca T et al (2012) The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn's disease. Ultrasound Med Biol 38:1324–1332PubMedCrossRef Quaia E, De Paoli L, Stocca T et al (2012) The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn's disease. Ultrasound Med Biol 38:1324–1332PubMedCrossRef
53.
Zurück zum Zitat Di Sabatino A, Fulle I, Ciccocioppo R et al (2002) Doppler enhancement after intravenous Levovist injection in Crohn's disease. Inflamm Bowel Dis 8:251–257PubMedCrossRef Di Sabatino A, Fulle I, Ciccocioppo R et al (2002) Doppler enhancement after intravenous Levovist injection in Crohn's disease. Inflamm Bowel Dis 8:251–257PubMedCrossRef
54.
Zurück zum Zitat Girlich C, Jung EM, Huber E et al (2011) Comparison between preoperative quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and operative macroscopic findings and results of histopathological scoring in Crohn's disease. Ultraschall Med 32:154–159PubMedCrossRef Girlich C, Jung EM, Huber E et al (2011) Comparison between preoperative quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and operative macroscopic findings and results of histopathological scoring in Crohn's disease. Ultraschall Med 32:154–159PubMedCrossRef
55.
Zurück zum Zitat Schreyer AG, Finkenzeller T, Gossmann H et al (2008) Microcirculation and perfusion with contrast enhanced ultrasound (CEUS) in Crohn's disease: first results with linear contrast harmonic imaging (CHI). Clin Hemorheol Microcirc 40:143–155PubMedCrossRef Schreyer AG, Finkenzeller T, Gossmann H et al (2008) Microcirculation and perfusion with contrast enhanced ultrasound (CEUS) in Crohn's disease: first results with linear contrast harmonic imaging (CHI). Clin Hemorheol Microcirc 40:143–155PubMedCrossRef
56.
Zurück zum Zitat Mansuri I, Fletcher JG, Bruining DH et al (2017) Endoscopic skipping of the terminal ileum in pediatric Crohn disease. AJR Am J Roentgenol 208:W216–W224PubMedCrossRef Mansuri I, Fletcher JG, Bruining DH et al (2017) Endoscopic skipping of the terminal ileum in pediatric Crohn disease. AJR Am J Roentgenol 208:W216–W224PubMedCrossRef
57.
Zurück zum Zitat Dillman JR, Rubin JM, Johnson LA et al (2017) Can contrast-enhanced sonography detect bowel wall fibrosis in mixed inflammatory and fibrotic Crohn disease lesions in an animal model? J Ultrasound Med 36:523–530PubMedPubMedCentralCrossRef Dillman JR, Rubin JM, Johnson LA et al (2017) Can contrast-enhanced sonography detect bowel wall fibrosis in mixed inflammatory and fibrotic Crohn disease lesions in an animal model? J Ultrasound Med 36:523–530PubMedPubMedCentralCrossRef
58.
Zurück zum Zitat Abraham BP, Mehta S, El-Serag HB (2012) Natural history of pediatric-onset inflammatory bowel disease: a systematic review. J Clin Gastroenterol 46:581–589PubMedPubMedCentralCrossRef Abraham BP, Mehta S, El-Serag HB (2012) Natural history of pediatric-onset inflammatory bowel disease: a systematic review. J Clin Gastroenterol 46:581–589PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Benchimol EI, Fortinsky KJ, Gozdyra P et al (2011) Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 17:423–439PubMedCrossRef Benchimol EI, Fortinsky KJ, Gozdyra P et al (2011) Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 17:423–439PubMedCrossRef
62.
Zurück zum Zitat Gasparetto M, Guariso G, Pozza LV et al (2016) Clinical course and outcomes of diagnosing inflammatory bowel disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy. BMC Gastroenterol 16:35PubMedPubMedCentralCrossRef Gasparetto M, Guariso G, Pozza LV et al (2016) Clinical course and outcomes of diagnosing inflammatory bowel disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy. BMC Gastroenterol 16:35PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat Horn CB, Tian D, Bochicchio GV, Turnbull IR (2018) Incidence, demographics, and outcomes of nonoperative management of appendicitis in the United States. J Surg Res 223:251–258PubMedCrossRef Horn CB, Tian D, Bochicchio GV, Turnbull IR (2018) Incidence, demographics, and outcomes of nonoperative management of appendicitis in the United States. J Surg Res 223:251–258PubMedCrossRef
64.
Zurück zum Zitat Zhang F, Miao LY, Ge HY et al (2018) Usefulness of contrast-enhanced ultrasound in differentiating inflammatory bowel disease from colon cancer. Ultrasound Med Biol 44:124–133PubMedCrossRef Zhang F, Miao LY, Ge HY et al (2018) Usefulness of contrast-enhanced ultrasound in differentiating inflammatory bowel disease from colon cancer. Ultrasound Med Biol 44:124–133PubMedCrossRef
66.
Zurück zum Zitat Epelman M, Daneman A, Navarro OM et al (2007) Necrotizing enterocolitis: review of state-of-the-art imaging findings with pathologic correlation. Radiographics 27:285–305PubMedCrossRef Epelman M, Daneman A, Navarro OM et al (2007) Necrotizing enterocolitis: review of state-of-the-art imaging findings with pathologic correlation. Radiographics 27:285–305PubMedCrossRef
67.
Zurück zum Zitat Al-Hamad S, Hackam DJ, Goldstein SD et al (2018) Contrast-enhanced ultrasound and near-infrared spectroscopy of the neonatal bowel: novel, bedside, noninvasive, and radiation-free imaging for early detection of necrotizing enterocolitis. Am J Perinatol 35:1358–1365PubMedCrossRef Al-Hamad S, Hackam DJ, Goldstein SD et al (2018) Contrast-enhanced ultrasound and near-infrared spectroscopy of the neonatal bowel: novel, bedside, noninvasive, and radiation-free imaging for early detection of necrotizing enterocolitis. Am J Perinatol 35:1358–1365PubMedCrossRef
Metadaten
Titel
Contrast-enhanced ultrasound of the pediatric bowel
verfasst von
Ami Gokli
Jonathan R. Dillman
Paul D. Humphries
Damjana Ključevšek
Hans-Joachim Mentzel
Erika Rubesova
Marcelo S. Takahashi
Sudha A. Anupindi
Publikationsdatum
12.05.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 12/2021
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-020-04868-x

Weitere Artikel der Ausgabe 12/2021

Pediatric Radiology 12/2021 Zur Ausgabe

Contrast-enhanced ultrasound (CEUS) in children

Emerging contrast-enhanced ultrasound applications in children

Contrast-enhanced Ultrasound 4 (Ceus) in Children

Contrast-enhanced ultrasound of the small organs in children

Contrast-enhanced ultrasound (CEUS) in children

Contrast-enhanced ultrasound in pediatric interventional radiology

Contrast-enhanced ultrasound (CEUS) in children

Contrast-enhanced ultrasound in pediatric echocardiography

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.