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25.10.2018 | Research Article

Contribution of the GSTP1 c.313A>G variant to hearing loss risk in patients exposed to platin chemotherapy during childhood

verfasst von: P. H. P. Liberman, M. V. S. Goffi-Gomez, C. Schultz, P. L. Jacob, C. A. A. de Paula, E. L. Sartorato, G. T. Torrezan, E. N. Ferreira, D. M. Carraro

Erschienen in: Clinical and Translational Oncology | Ausgabe 5/2019

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Abstract

Background and aim

Ototoxicity is a potential adverse effect of chemotherapy with platin drugs, such as cisplatin and carboplatin, in children. Hearing loss (HL) affecting frequencies below 4 kHz can compromise speech perception. The aim of this study was to investigate whether genetic variants previously implicated in ototoxicity are associated with HL overall and HL below 4 kHz in pediatric oncology patients treated with cisplatin or carboplatin.

Materials and methods

Patients given cisplatin or carboplatin for a pediatric cancer at least 5 years prior to the start of the study were enrolled. The patients underwent comprehensive audiological evaluations and genotyping to detect the presence of the GJB2 c.35delG, GSTP1 c.313A>G, and MT-RNR1 m.1555A>G polymorphisms.

Results

HL was identified in 31/61 patients (50.8%), including 28/42 treated with cisplatin (66.6%) and 3/19 treated with carboplatin (15.8%). HL was associated with higher mean doses of cisplatin (p = .002) and carboplatin (p = .010). The c.313A>G variant of GSTP1 (heterozygous or homozygous) was detected in 31/61 patients (50.8%). An association between this variant allele and HL involving frequencies ≤ 4 kHz was identified (p = .020; 10-fold vs. non-carriers). No associations with HL were observed for GJB2 or MT-RNR1 gene variants.

Conclusion

The GSTP1 c.313A>G variant may increase the risk of low-frequency HL in pediatric oncology patients treated with cisplatin or carboplatin chemotherapy.

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Titel: Contribution of the GSTP1 c.313A>G variant to hearing loss risk in patients exposed to platin chemotherapy during childhood
verfasst von: P. H. P. Liberman
M. V. S. Goffi-Gomez
C. Schultz
P. L. Jacob
C. A. A. de Paula
E. L. Sartorato
G. T. Torrezan
E. N. Ferreira
D. M. Carraro
Publikationsdatum: 25.10.2018
Verlag: Springer International Publishing
Erschienen in: Clinical and Translational Oncology / Ausgabe 5/2019
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-018-1964-7

Springer Medizin

Contribution of the GSTP1 c.313A>G variant to hearing loss risk in patients exposed to platin chemotherapy during childhood