Introduction
Diseased condition | 23a | 27a | 24 | 23b | 27b | Reference |
---|---|---|---|---|---|---|
Acute lymphoblastic leukemia (ALL) | u | u | u | u | u | [28] |
Acute myeloid leukemia (AML) | u | u | u | u | u | [28] |
Acute promyelocytic leukemia (APL) | d | d | d | [41] | ||
Autism spectrum disorder (ASD) | d | d | [103] | |||
Bladder cancer | u | u | [42] | |||
Breast cancer | u | |||||
Cardiac hypertrophy | u | u | u | u | u | |
Colorectal cancer | d | d | u | d | ||
Gastric cancer (stomach) | u | u | u | |||
Glioblastoma | u | u | u | [106] | ||
Heart failure | u | u | u | [107] | ||
Hepatocellular carcinoma (HCC) | u | u | u | [13] | ||
Kidney cancer | u | [108] | ||||
Lung cancer | u | d | [109] | |||
Lupus nephritis | [110] | |||||
Malignant melanoma | d | d | [111] | |||
Oral squamous cell carcinoma (OSCC) | d | d | d | [112] | ||
Pancreatic cancer | u | u | u | |||
Papillary thyroid carcinoma (PTC) | u | [114] | ||||
Prostate cancer | u/d | u/d | u | u/d | u/d | |
Schizophrenia | d | [117] | ||||
Serous ovarian cancer | u | u | u | [118] | ||
Ulcerative colitis (UC) | u | u | u | [119] | ||
Uterine leiomyoma (ULM) | u | u | [120] | |||
Vesicular stomatitis | NA | [121] |
miR-23 cluster paralogs
Regulation of the miRNA cluster
Functions of the miR-23a~27a~24-2 cluster
miR-23a~27a~24-2 cluster in tumorigenesis
Function of the individual members of the miR-23a~27a~24-2 cluster
miR-23a
miR-23a in cancer
miR-23a in cardiac hypertrophy
miR-23a in muscle atrophy
miR-27a
miR-27a in cancer and multidrug resistance of cancer
miR-27a in osteoarthritis pathological process
miR-27a in differentiation
miR-27a regulates fat metabolism and cell proliferation
miR-24
miR-24 in haematopoetic differentiation
miR-24 in tumorigenesis
miR-24 in phenotypic plasticity
Biological relevance of miR-23a~27a~24-2 cluster as revealed by bioinformatic analysis
Gene Name | Definition |
---|---|
ADAM19 | ADAM metallopeptidase domain 19 (meltrin beta) |
ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 |
CSNK1G1 | Casein kinase 1, gamma 1 |
EBF3 | Early B-cell factor 3 |
KPNA3 | Karyopherin alpha 3 (importin alpha 4) |
LIMK2 | LIM domain kinase 2 |
NCOA1 | Nuclear receptor coactivator 1 |
NLK | Nemo-like kinase |
PLEKHH2 | Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 |
RAP1B | RAP1B, member of RAS oncogene family |
SOCS6 | Suppressor of cytokine signaling 6 |