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International Archives of Occupational and Environmental Health

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09.09.2020 | Letter to the Editor

Copper-zinc imbalance and renal tubular damage in a population of chronic environmental cadmium exposure

verfasst von: Tomoyuiki Kawada

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 2/2021

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Eom et al. (2020) conducted a cross-sectional study to assess the relationship between environmental cadmium (Cd) exposure, copper–zinc imbalance and renal tubular damage in inhabitants living in a Cd-polluted area. The geometric mean of urinary Cd was 2.25 μg/g creatinine, and 2 μg/g creatinine was used for the cut-off point of binary Cd exposure classification. The risk of renal tubular damage was significantly associated with urinary Cd level, particularly in the lowest or highest serum copper-to-zinc ratio (CZR) tertile groups. I have some concerns about their study. …

Eom SY et al (2020) Copper-zinc imbalance induces kidney tubule damage and oxidative stress in a population exposed to chronic environmental cadmium. Int Arch Occup Environ Health 93(3):337–344. https://doi.org/10.1007/s00420-019-01490-9CrossRef

Kawada T (2014) Multiple metal exposures and renal effect: their magnitude of contribution. Occup Environ Med 71(2):154. https://doi.org/10.1136/oemed-2013-101698CrossRef

Liu J, Qu W, Kadiiska MB (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238:209–214. https://doi.org/10.1016/j.taap.2009.01.029CrossRef

Titel: Copper-zinc imbalance and renal tubular damage in a population of chronic environmental cadmium exposure
verfasst von: Tomoyuiki Kawada
Publikationsdatum: 09.09.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 2/2021
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-020-01578-7

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