Erschienen in:
01.12.2007 | Original Paper
Coronary flow reserve after l-thyroxine therapy in Hashimoto’s thyroiditis patients with subclinical and overt hypothyroidism
verfasst von:
Huseyin Oflaz, Ramazan Kurt, Fatma Sen, Imran Onur, Arif Oguzhan Cimen, Ali Elitok, Kultigin Turkmen, Burak Pamukcu, Erdem Kasikcioglu, Zehra Bugra, Fehmi Mercanoglu, Nese Ozbey
Erschienen in:
Endocrine
|
Ausgabe 3/2007
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Abstract
Backgound/Aims Overt and subclinical hypothyroidism are reported to be associated with increased cardiovascular disease risk. We have used coronary flow reserve (CFR) measurement by trans-thoracic Doppler echocardiography (TTDE) to determine coronary microvascular function in Hashimoto’s thyroiditis patients with overt and subclinical hypothyroidism and to evaluate effects of l-thyroxine replacement on coronary endothelial function. Methods In total, 10 overt hypothyroid patients, 10 subclinical hypothyroid patients, and 10 controls were enrolled. FT4, TSH, anti-thyroid antibodies, lipid profile, insulin, glucose, HOMA-IR, physical parameters, and CFR measured by TTDE were recorded before and after 6 months of l-thyroxine replacement in all groups. Results CFR values of all hypothyroid patients at baseline were significantly lower than those in controls. After l-thyroxine, CFR increased significantly in overt and subclinical hypothyroidism with respect to the baseline measurements (P < 0.05). When baseline and second measurements were evaluated collectively for patients and controls, CFR was positively correlated with FT4 levels (r = 0.31, P = 0.01) and negatively correlated with TSH and HOMA-IR (r = −0.38, P = 0.002 and r = −0.42, P < 0.001, respectively). Conclusion Subclinical as well as overt hypothyroid patients have impaired coronary microvascular function which improved after l-thyroxine therapy. Treatment of Hashimoto’s thyroiditis patients with subclinical hypothyroidism should be considered to improve cardiovascular disease risk.