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Erschienen in:
01.08.2018 | Correction
Correction to: Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data
Erschienen in: Clinical Drug Investigation | Ausgabe 8/2018
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In the original publication, the Estimate column with values under Multivariate meta-regression (LOCF) in Table 2 was missed. The corrected Table 2 is shown below:
Table 2
Findings by meta-regression analyses in placebo-controlled randomized clinical trials by MMRM and LOCF
|
Variable
|
Univariate meta-regression (MMRM)
|
Univariate meta-regression (LOCF)
|
||||
|---|---|---|---|---|---|---|
|
Estimate
|
SE
|
p value
|
Estimate
|
SE
|
p value
|
|
|
Patient factors
|
||||||
|
Diagnosis
|
− 9.304
|
3.107
|
0.003
|
|||
|
Severity
|
−0.127
|
0.104
|
0.225
|
− 0.101
|
0.164
|
0.539
|
|
Age
|
0.747
|
0.480
|
0.120
|
0.707
|
0.483
|
0.144
|
|
% Male
|
0.149
|
0.094
|
0.111
|
0.104
|
0.112
|
0.352
|
|
Investigator factor
|
||||||
|
Rater training
|
− 4.321
|
2.032
|
0.033
|
− 2.384
|
2.279
|
0.295
|
|
Study design factors
|
||||||
|
Study duration
|
− 2.130
|
0.740
|
0.004
|
2.267
|
0.757
|
0.003
|
|
Placebo lead-in
|
− 1.039
|
1.878
|
0.580
|
5.618
|
2.057
|
0.006
|
|
Number of treatment arms
|
− 1.241
|
1.205
|
0.303
|
0.774
|
1.123
|
0.491
|
|
Placebo randomization rate
|
− 0.014
|
0.236
|
0.953
|
0.160
|
0.162
|
0.324
|
|
Regimen
|
2.466
|
1.658
|
0.137
|
− 1.191
|
2.309
|
0.606
|
|
Active comparator
|
−2.324
|
1.818
|
0.201
|
4.407
|
2.573
|
0.087
|
|
Treatment setting
|
− 3.463
|
1.425
|
0.015
|
− 1.329
|
2.737
|
0.627
|
|
Operational factors
|
||||||
|
Number of study sites
|
− 0.096
|
0.048
|
0.047
|
− 0.023
|
0.049
|
0.640
|
|
Number of countries
|
− 0.653
|
0.297
|
0.028
|
− 0.328
|
0.339
|
0.333
|
|
Study period
|
− 0.042
|
0.152
|
0.781
|
0.126
|
0.144
|
0.381
|
|
Enrollment Speed
|
5.106
|
1.674
|
0.002
|
− 0.782
|
3.293
|
0.812
|
|
Variable
|
Multivariate meta-regression (MMRM)
|
Multivariate meta-regression (LOCF)
|
||||
|---|---|---|---|---|---|---|
|
Estimate
|
SE
|
p value
|
Estimate
|
SE
|
p value
|
|
|
Patient factors
|
||||||
|
Diagnosis
|
− 4.490
|
3.297
|
0.173
|
|||
|
Investigator factor
|
||||||
|
Rater training
|
− 3.607
|
2.990
|
0.228
|
|||
|
Study design factors
|
||||||
|
Study duration
|
0.866
|
1.231
|
0.482
|
1.567
|
0.747
|
0.036
|
|
Placebo lead-in
|
2.994
|
2.119
|
0.158
|
|||
|
Active comparator
|
1.914
|
2.384
|
0.422
|
|||
|
Treatment setting
|
− 4.217
|
1.971
|
0.032
|
|||
|
Operational factors
|
||||||
|
Number of study sites
|
0.149
|
0.092
|
0.106
|
|||
|
Number of countries
|
− 0.864
|
0.399
|
0.030
|
|||
|
Enrollment speed
|
3.876
|
2.943
|
0.188
|
|||