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01.08.2012 | Brief Report

Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus

verfasst von: Abdel Raouf Abou El Azm, Hassan El-Bate, Lobna Abo-Ali, Nagwa Mansour, Hussin Ghoraba, Mohamed Labib Salem

Erschienen in: Archives of Virology | Ausgabe 8/2012

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Abstract

Liver is considered the target of hepatitis C virus (HCV), which has marked tropism for hepatocytes. In this study, we investigated changes in bone marrow (BM) and blood and their correlation with viremia level in 30 pale patients with chronic HCV who were selected before antiviral therapy. Patients with BM positive for HCV RNA (53.33 %) showed moderate to high viremia, while patients with BM negative for RNA (46.67 %) had low viremia. There was no significant difference in the liver histopathology between patients with HCV-RNA-negative and positive BM. Patients with BM positive for HCV RNA showed significant changes in BM cells, including the degree of immune complex deposition and alterations in peripheral blood counts compared to patients with BM negative for RNA and healthy controls, suggesting that BM changes could be a sequel or a reservoir for HCV viremia.

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Titel: Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus
verfasst von: Abdel Raouf Abou El Azm
Hassan El-Bate
Lobna Abo-Ali
Nagwa Mansour
Hussin Ghoraba
Mohamed Labib Salem
Publikationsdatum: 01.08.2012
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 8/2012
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1321-z

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