Erschienen in:
21.04.2017 | Letter to the Editor
cR and pR: The Residual Tumor Classification Revisited
verfasst von:
Arne Warth
Erschienen in:
Pathology & Oncology Research
|
Ausgabe 1/2018
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Excerpt
Introduced by the American Joint Committee on Cancer (AJCC) in 1978 [
1] and subsequently established in the 4th edition of the Tumor, Node, Metastasis (TNM) system the definition and interpretation of the R Classification has significantly changed over time. R describes residual tumor following antitumor therapies and thus reflects therapy effects. Every report on a tumor specimen should include a statement concerning the R status [
2]. The intention of the initial R Classification was a feedback to the surgeon concerning the completeness of the resection [
3,
4]. For specific entities, e.g. colorectal cancer [
5], the R Classification was further developed into a prognostic parameter [
2]. In the following years it was extended from the locoregional tumor to metastases, thus shifting its meaning to a systemic residual tumor burden following any primary therapy [
6‐
9]. …
