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Current Bladder Dysfunction Reports

Erschienen in:

07.12.2020 | NEUROGENIC BLADDER (C POWELL, SECTION EDITOR)

Cranberry Products for the Prevention of Catheter-Associated Urinary Tract Infections

verfasst von: Lunan Ji, Gina M. Badalato, Doreen E. Chung, Kimberly L. Cooper, Matthew P. Rutman

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2020

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Abstract

Purpose of Review

In this review, we examine the current literature regarding the use of cranberry and other complimentary methods for the prevention of catheter-associated urinary tract infections (CAUTIs).

Recent Findings

Some studies have suggested cranberry products may have a positive effect in reducing the incidence of CAUTIs in patients with normal bladder function receiving short-term catheterization, while other studies have failed to show the benefits of cranberry products for the reduction of CAUTIs.

Summary

While there is some data suggesting cranberry-derived products may reduce CAUTIs in specific patient populations, there is currently overall insufficient clinical data to recommend broad usage of cranberry products for the reduction of CAUTIs. Many of the studies reviewed have significant limitations in size, design, and lack standardization.

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Gupta K, Chou M, Howell A, Wobbe C, Grady R, Stapleton A. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol. 2007;177(6):2357–60. https://doi.org/10.1016/j.juro.2007.01.114.CrossRefPubMedPubMedCentral

Howell AB, Botto H, Combescure C, Blanc-Potard A-B, Gausa L, Matsumoto T, et al. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010;10(1). https://doi.org/10.1186/1471-2334-10-94.

Ohnishi R, Ito H, Kasajima N, Kaneda M, Kariyama R, Kumon H, et al. Urinary excretion of anthocyanins in humans after cranberry juice ingestion. Biosci Biotechnol Biochem. 2006;70(7):1681–7. https://doi.org/10.1271/bbb.60023.CrossRefPubMed

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Wang C-H, Fang C-C, Chen N-C, Liu SS-H, Yu P-H, Wu T-Y, et al. Cranberry-containing products for prevention of urinary tract infections in susceptible populations. Arch Intern Med. 2012;172(13). https://doi.org/10.1001/archinternmed.2012.3004.

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Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012. https://doi.org/10.1002/14651858.cd001321.pub5.

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Jepson R, Craig J, Williams G. Cranberry products and prevention of urinary tract infections. JAMA. 2013;310(13):1395. https://doi.org/10.1001/jama.2013.277509.CrossRefPubMed

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Anger J, Lee U, Ackerman AL, Chou R, Chughtai B, Clemens JQ, et al. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU Guideline. J Urol. 2019;202(2):282–9. https://doi.org/10.1097/JU.0000000000000296.CrossRefPubMed

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Foxman B, Cronenwett AEW, Spino C, Berger MB, Morgan DM. Cranberry juice capsules and urinary tract infection after surgery. Obstet Gynecol Surv. 2015;70(12):749–50. https://doi.org/10.1097/ogx.0000000000000267.CrossRef

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• Gunnarsson AK, Gunningberg L, Larsson S, Jonsson KB. Cranberry juice concentrate does not significantly decrease the incidence of acquired bacteriuria in female hip fracture patients receiving urine catheter: a double-blind randomized trial. Clin Interv Aging. 2017;12:137–43. https://doi.org/10.2147/cia.s113597A randomized study of cranberry capsules for the prevention of CAUTIs in short-term catheterized patients who had undergone repair of hip fractures did not demonstrate a benefit. However, study was significantly underpowered compared to initial design.CrossRefPubMedPubMedCentral

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• Shatkin-Margolis A, Warehime J, Pauls RN. Cranberry supplementation does not reduce urinary tract infections in patients with indwelling catheters after pelvic reconstructive surgery. Female Pelvic Med Reconstruct Surg. 2018;24(2):130–4. https://doi.org/10.1097/spv.0000000000000507A retrospective study of cranberry capsules for the prevention of CAUTIs in short-term catheterized female patients who underwent pelvic reconstructive study did not show a reduction in UTIs.CrossRef

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• Thomas D, Rutman M, Cooper K, Abrams A, Finkelstein J, Chughtai B. Does cranberry have a role in catheter-associated urinary tract infections? Can Urol Assoc J. 2017;11(11). https://doi.org/10.5489/cuaj.4472A small prospective study suggesting a positive benefit of cranberry capsule with a standardized dose of PAC could be effective in reducing CAUTIs in patients with chronic indwelling catheters.

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• Sappal S, Goetz LL, Vince R, Klausner AP. Randomized trial of concentrated proanthocyanidins (PAC) for acute reduction of bacteriuria in male veterans with spinal cord injury utilizing clean intermittent catheterization. Spinal Cord Ser Cases. 2018;4(1). https://doi.org/10.1038/s41394-018-0087-2A small prospective study of cranberry in SCI patients did not demonstrate a benefit fit in subjective urine quality or reduction in colony count.

21.

Hess MJ, Hess PE, Sullivan MR, Nee M, Yalla SV. Evaluation of cranberry tablets for the prevention of urinary tract infections in spinal cord injured patients with neurogenic bladder. Spinal Cord. 2008;46(9):622–6. https://doi.org/10.1038/sc.2008.25.CrossRefPubMed

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Lo TS, Hammer KD, Zegarra M, Cho WC. Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era. Expert Rev Anti-Infect Ther. 2014;12(5):549–54. https://doi.org/10.1586/14787210.2014.904202.CrossRefPubMed

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Vainrub B, Musher DM. Lack of effect of methenamine in suppression of, or prophylaxis against, chronic urinary infection. Antimicrob Agents Chemother. 1977;12(5):625–9. https://doi.org/10.1128/aac.12.5.625.CrossRefPubMedPubMedCentral

Titel: Cranberry Products for the Prevention of Catheter-Associated Urinary Tract Infections
verfasst von: Lunan Ji
Gina M. Badalato
Doreen E. Chung
Kimberly L. Cooper
Matthew P. Rutman
Publikationsdatum: 07.12.2020
Verlag: Springer US
Erschienen in: Current Bladder Dysfunction Reports / Ausgabe 4/2020
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI: https://doi.org/10.1007/s11884-020-00610-3

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Abstract

Purpose of Review

Recent Findings

Summary

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