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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.07.2014

CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland

verfasst von: Amy Renee Sullivan, Fiona Jane Pixley

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2014

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Abstract

Colony-stimulating factor-1 (CSF-1), also known as macrophage-colony stimulating factor (M-CSF), is the primary growth factor regulating survival, proliferation and differentiation of macrophages. It is also a potent chemokine for macrophages and monocytes. Signaling via the CSF-1 receptor (CSF-1R) is necessary for the production of almost all tissue resident macrophage populations and these macrophages participate, via trophic mechanisms, in the normal development and homeostasis of tissues and organs in which they reside, including the mammary gland. The drawback of this close interaction between macrophages and parenchymal cells is that dysregulation of macrophage trophic functions assists in the development and progression of many cancers, including breast cancer. Furthermore, tumour cells secrete CSF-1 to attract more macrophages to the tumour microenvironment where CSF-1R signaling frequently drives the behaviour of these tumour-associated macrophages (TAMs) to promote tumour progression and metastasis. Evidence is mounting that treated tumours secrete more CSF-1 and the increased recruitment of TAMs limits treatment efficacy. Thus, therapeutic targeting of the CSF-1R to inhibit TAM function is likely to enhance tumour response and improve patient outcomes in the treatment of cancer, including breast cancer.

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Titel: CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland
verfasst von: Amy Renee Sullivan
Fiona Jane Pixley
Publikationsdatum: 01.07.2014
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2014
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-014-9320-1

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CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland

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