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Journal of the Association for Research in Otolaryngology
Erschienen in: Journal of the Association for Research in Otolaryngology 5/2022

24.08.2022 | Review

Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss

verfasst von: Fan Wu, Kumar Sambamurti, Suhua Sha

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 5/2022

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Abstract

Adeno-associated viruses (AAVs) are viral vectors that offer an excellent platform for gene therapy due to their safety profile, persistent gene expression in non-dividing cells, target cell specificity, lack of pathogenicity, and low immunogenicity. Recently, gene therapy for genetic hearing loss with AAV transduction has shown promise in animal models. However, AAV transduction for gene silencing or expression to prevent or manage acquired hearing loss is limited. This review provides an overview of AAV as a leading gene delivery vector for treating genetic hearing loss in animal models. We highlight the advantages and shortcomings of AAV for investigating the mechanisms and preventing acquired hearing loss. We predict that AAV-mediated gene manipulation will be able to prevent acquired hearing loss.
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Metadaten
Titel
Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss
verfasst von
Fan Wu
Kumar Sambamurti
Suhua Sha
Publikationsdatum
24.08.2022
Verlag
Springer US
Erschienen in
Journal of the Association for Research in Otolaryngology / Ausgabe 5/2022
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI
https://doi.org/10.1007/s10162-022-00866-y

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