nach oben

Rheumatology International

Erschienen in:

01.06.2009 | Review Article

Cutaneous manifestations associated with rheumatoid arthritis

verfasst von: T. Yamamoto

Erschienen in: Rheumatology International | Ausgabe 9/2009

Einloggen, um Zugang zu erhalten

Abstract

Rheumatoid arthritis presents various cutaneous manifestations, either specific or nonspecific skin features, which are induced by the activation of inflammatory cells (neutrophils, lymphocytes, macrophages), vasculopathy, vasculitis, acral deformity, drugs, and so on. These include (1) specific findings, (2) findings due to vascular impairment, (3) findings due to immune dysfunction, (4) characteristic neutrophilic conditions, and (5) miscellaneous conditions. On the other hand, some of the specific manifestations show common histopathological features such as palisading granulomas with necrobiosis. It is important to recognize the common and/or uncommon skin conditions of RA for all clinicians associated with RA therapy.

Soderstrom CW (1979) Cutaneous manifestations of rheumatoid arthritis. Cutis 24:553–562PubMed

Sibbitt WL, Williams RC (1982) Cutaneous manifestations of rheumatoid arthritis. Int J Dermatol 21:563–572. doi:10.1111/j.1365-4362.1982.tb02037.x PubMedCrossRef

Jorizzo JL, Daniels JC (1983) Dermatologic conditions reported in patients with rheumatoid arthritis. J Am Acad Dermatol 8:439–457. doi:10.1016/S0190-9622(83)70049-6 PubMedCrossRef

Yamamoto T, Ohkubo H, Nishioka K (1995) Skin manifestations associated with rheumatoid arthritis. J Dermatol 22:324–329PubMed

Sayah A, English JCIII (2005) Rheumatoid arthritis: a review of the cutaneous manifestations. J Am Acad Dermatol 53:191–209. doi:10.1016/j.jaad.2004.07.023 PubMedCrossRef

Chu P, Connolly K, LeBoit PE (1994) The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol 130:1278–1283. doi:10.1001/archderm.130.10.1278 PubMedCrossRef

Sangueza OP, Caudell MD, Mengesha YM, Davis LS, Barnes CJ, Griffin JE, Fleischer AB, Jorizzo JL (2002) Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol 47:251–257. doi:10.1067/mjd.2002.124620 PubMedCrossRef

Magro CM, Crowson AN (2003) The spectrum of cutaneous lesions in rheumatoid arthritis: a clinical and pathological study of 43 patients. J Cutan Pathol 30:1–10. doi:10.1034/j.1600-0560.2003.300101.x PubMedCrossRef

Appleton MAC, Ismail SM (1996) Ulcerating rheumatoid nodule of the vulva. J Clin Pathol 49:85–87. doi:10.1136/jcp.49.1.85 PubMedCrossRef

10.

Horn RT, Goette DK (1982) Perforating rheumatoid nodule. Arch Dermatol 118:696–697. doi:10.1001/archderm.118.9.696 PubMedCrossRef

11.

Patterson JW (1988) Rheumatoid nodule and subcutaneous granuloma annulare: a comparative histologic study. Am J Dermatopathol 10:1–8PubMedCrossRef

12.

Ziff M (1990) The rheumatoid nodule. Arthritis Rheum 33:761–767. doi:10.1002/art.1780330601 PubMedCrossRef

13.

Wikaningrum R, Highton J, Parker A, Coleman M, Hessian PA, Roberts-Thomson PJ, Ahern MJ, Smith MD (1998) Pathogenic mechanisms in the rheumatoid nodule: comparison of proinflammatory cytokine production and cell adhesion molecule expression I rheumatoid nodules and synovial membranes from the same patient. Arthritis Rheum 41:1783–1797. doi:10.1002/1529-0131(199810)41:10<1783::AID-ART10>3.0.CO;2-W PubMedCrossRef

14.

Hessian PA, Highton J, Kean A, Sun CK, Chin M (2003) Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granloma. Arthritis Rheum 48:334–338. doi:10.1002/art.10776 PubMedCrossRef

15.

Yamamoto T, Matsunaga T, Yokozeki H, Katayama I, Nishioka K (1998) Inducible nitric oxide synthase expression on a rheumatoid nodule and in rheumatoid papules. Br J Dermatol 139:739–740. doi:10.1046/j.1365-2133.1998.02479.x PubMedCrossRef

16.

Kekow J, Welte T, Kellner U, Pap T (2002) Development of rheumatoid nodules during anti-tumor necrosis factor alpha therapy with etanercept. Arthritis Rheum 46:843–844. doi:10.1002/art.10096 PubMedCrossRef

17.

Scrivo R, Spadaro A, Iagnocco A, Valesini G (2007) Appearance of rheumatoid nodules following anti-tumor necrosis factor alpha treatment with adalimumab for rheumatoid arthritis. Clin Exp Rheumatol 25:117PubMed

18.

Cronstein BN, Dwight N, Ostad E (1993) The anti-inflammatory mechanisms of methotrexate. J Clin Invest 92:2675–2682. doi:10.1172/JCI116884 PubMedCrossRef

19.

Merrill JT, Shen C, Schreibman D, Coffey D, Zakharenko O, Fisher R, Lahita RG, Salmon J, Cronstein BN (1997) Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis Rheum 40:1308–1315PubMed

20.

Smith ML, Jorizzo JL, Semble E, Arrington JH, White WL (1989) Rheumatoid papules: lesions showing features of vasculitis and palisading granuloma. J Am Acad Dermatol 20:348–352. doi:10.1016/S0190-9622(89)70044-X PubMedCrossRef

21.

Goerttler E, Kutzner H, Peter HH, Requena L (1999) Methotrexate-induced papular eruption in patients with rheumatic diseases: a distinctive adverse cutaneous reaction produced by methotrexate in patients with collagen vascular diseases. J Am Acad Dermatol 40:702–707. doi:10.1016/S0190-9622(99)70150-7 PubMedCrossRef

22.

Wilmoth GJ, Perniciaro C (1996) Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease. J Am Acad Dermatol 34:753–759. doi:10.1016/S0190-9622(96)90008-0 PubMedCrossRef

23.

Ackerman AB (1978) Histologic diagnosis of inflammatory skin diseases: a method by pattern analysis. Lee & Febiger, Philadelphia, pp 449–450

24.

Yamamoto T, Ohkubo H, Nishioka K (1994) Rheumatoid neutrophilic dermatitis. Int J Dermatol 33:798–800. doi:10.1111/j.1365-4362.1994.tb01000.x PubMedCrossRef

25.

Lu CI, Yang CH, Hong HS (2004) A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy. J Am Acad Dermatol 51:94–96. doi:10.1016/j.jaad.2003.12.054 CrossRef

26.

MacAya A, Servitje O, Jucgla A, Peyri J (2000) Rheumatoid neutrophilic dermatitis associated with pyoderma gangrenosum. Br J Dermatol 142:1246–1248. doi:10.1046/j.1365-2133.2000.03565.x PubMedCrossRef

27.

Brown TS, Fearneyhough PK, Burruss JB, Callen JP (2001) Rheumatoid neutrophilic dermatitis in a woman with seronegative rheumatoid arthritis. J Am Acad Dermatol 45:596–600. doi:10.1067/mjd.2001.119031 PubMedCrossRef

28.

Yamamoto T, Matsunaga T, Nishioka K (2003) Rheumatoid neutrophilic dermatitis, rheumatoid papules, and rheumatoid nodules in a patient with seronegative rheumatoid arthritis. J Am Acad Dermatol 48:634–635. doi:10.1067/mjd.2003.58 PubMedCrossRef

29.

Dyckman CJ, Galens GJ, Good AE (1965) Linear subcutaneous bands in rheumatoid arthritis: an unusual form of rheumatoid granuloma. Ann Intern Med 63:134–140

30.

Betlloch I, Moragon M, Jorda E, Jimenez A, Ramon D, Verdeguer JM (1988) Linear rheumatoid nodule. Int J Dermatol 27:645–646. doi:10.1111/j.1365-4362.1988.tb02424.x PubMedCrossRef

31.

Jorizzo JL, Olansky AJ, Stanley RJ (1982) Superficial ulcerating necrobiosis in rheumatoid arthritis: a variant of the necrobiosis lipoidica-rheumatoid nodule spectrum? Arch Dermatol 118:255–259. doi:10.1001/archderm.118.4.255 PubMedCrossRef

32.

Chen SY, Kamatani N, Kashiwazaki S (1998) Multiple extra-articular synovial cyst formation: case report and review of the literature. Ann Rheum Dis 57:169–171PubMedCrossRef

33.

Takiwaki H, Adachi A, Kohno H, Ogawa Y (2004) Intravascular or intralymphatic histocytosis associated with rheumatoid arthritis: a report of 4 cases. J Am Acad Dermatol 50:585–590. doi:10.1016/j.jaad.2003.09.025 PubMedCrossRef

34.

Zonana-Nacach A, Jimenez-Balderas FJ, Martinez-Osuna P, Mintz G (1994) Intravenous cyclophosphamide pulses in the treatment of pyoderma gangrenosum associated with rheumatoid arthritis: report of 2 cases and review of the literature. J Rheumatol 21:1352–1356PubMed

35.

Colier PM, Neill SM, Branfoot AC, Staughton RC (1990) Erythema elevatum diutinum: a solitary lesion in a patient with rheumatoid arthritis. Clin Exp Dermatol 15:394–395. doi:10.1111/j.1365-2230.1990.tb02126.x CrossRef

36.

Delaporte E, Gaveau DJ, Piette FA, Bergoend HA (1989) Acute febrile neutrophilic dermatosis (Sweet’s syndrome): association with rheumatoid vasculitis. Arch Dermatol 125:1101–1104. doi:10.1001/archderm.125.8.1101 PubMedCrossRef

37.

Tran TA, DuPree M, Carlson JA (1999) Neutrophilic lobular (pustular) panniculitis associated with rheumatoid arthritis: a case report and review of the literature. Am J Dermatopathol 21:247–252. doi:10.1097/00000372-199906000-00007 PubMedCrossRef

38.

Yamamoto T, Furuse Y (1995) Erosive pustular dermatosis of the scalp associated with rheumatoid arthritis. Int J Dermatol 34:148. doi:10.1111/j.1365-4362.1995.tb03605.x PubMedCrossRef

39.

Klimiuk PA, Sierakowski S, Latosiewicz R, Skowronski J, Cylwik JP, Cylwik B, Chwieco J (2005) Histological patterns of synovitis and serum chemokines in patients with rheumatoid arthritis. J Rheumatol 32:1666–1672PubMed

40.

Hernandez-Beriain JA, Roman AS, Espinel ML, Segura-Garcia C (1996) Morphea and rheumatoid arthritis. Clin Exp Rheumatol 14:446–447PubMed

41.

Yamamoto T, Yokoyama A, Ohkubo H (1996) Discoid lupus erythematosus associated with rheumatoid arthritis. Acta Dermatol (Kyoto) 91:1–4

42.

Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18, 572 patients. Arthritis Rheum 50:1740–1751. doi:10.1002/art.20311 PubMedCrossRef

43.

Clarke LE, Junkins-Hopkins J, Seykora JT, Adler DJ, Elenitsas R (2007) Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin. J Am Acad Dermatol 56:686–690. doi:10.1016/j.jaad.2006.09.011 PubMedCrossRef

44.

Maruani A, Wierzbicka E, Machet MC, Abdallah-Lotf M, de Muret A, Machet L (2007) Reversal of multifocal cutaneous lymphoproliferative disease associated with Epstein–Barr virus after withdrawal of methotrexate therapy for rheumatoid arthritis. J Am Acad Dermatol 57:S69–S71. doi:10.1016/j.jaad.2005.09.015 PubMedCrossRef

45.

Hoshida Y, Xu JX, Fujita S, Nakamichi I, Ikeda J, Tomita Y, Nakatsuka S, Tamaru J, Iizuka A, Takeuchi T, Aozasa K (2007) Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34:322–331PubMed

46.

Michel C, Cribier B, Sibilia J, Kuntz JL, Grosshans E (1997) Nail abnormalities in rheumatoid arthritis. Br J Dermatol 137:958–962. doi:10.1111/j.1365-2133.1997.tb01559.x PubMedCrossRef

47.

Grant EN, Bellamy N, Buchanan WW, Grace EM, O’Leary S (1985) Statistical reappraisal of the clinical significance of nail beading in rheumatoid arthritis. Ann Rheum Dis 44:671–675. doi:10.1136/ard.44.10.671 PubMedCrossRef

48.

Douglas KMJ, Ladoyanni E, Treharne GJ, Hale ED, Erb N, Kitas GD (2006) Cutaneous abnormalities in rheumatoid arthritis compared with non-inflammatory rheumatic conditions. Ann Rheum Dis 65:1341–1345. doi:10.1136/ard.2005.048934 PubMedCrossRef

49.

Bicer A, Tursen U, Cimen OB, Kaya TI, Ozisik S, Ikizoglu G, Erdogan C (2003) Prevalence of dermatophytosis in patients with rheumatoid arthritis. Rheumatol Int 23:37–40. doi:10.1007/s00296-003-0294-3 PubMedCrossRef

50.

Nihei Y (1999) Cutaneous mucinous nodules associated with proliferating synovitis of rheumatoid arthritis. J Dermatol 26:229–235PubMed

51.

Umebayashi Y (2004) Mucinous nodules on the skin overlying a rheumatoid arthritic joint. J Dermatol 31:737–740PubMed

52.

Yokoyama E, Muto M (2006) Adult variant of self-healing papular mucinosis in a patient with rheumatoid arthritis: predominant proliferation of dermal dendritic cells expressing CD34 or factor XIIIa in association with dermal deposition of mucin. J Dermatol 33:30–35. doi:10.1111/j.1346-8138.2006.00005.x PubMedCrossRef

53.

Honda A, Fujimoto E, Kuroda K, Tajima S (2008) Cutaneous mucinous nodule in a patient with rheumatoid arthritis. J Dermatol 35:98–101. doi:10.1111/j.1346-8138.2008.00422.x PubMedCrossRef

54.

Papacharalambous VG, Pramatarov KD, Tsankov NK (1997) Development of pemphigus in a patient with rheumatoid arthritis during a course of gold therapy. Eur J Dermatol 7:65–66

55.

Ruocco V, de Angelis E, Lambardi ML (1993) Drug pemphigus. II. Pathomechanisms and experimental investigations. Clin Dermatol 11:507–513. doi:10.1016/0738-081X(93)90158-9 PubMedCrossRef

56.

Yamamoto T, Yokozeki H (2007) Yellow nails under bucillamine therapy for rheumatoid arthritis: a report of two cases. Rheumatol Int 27:603–604. doi:10.1007/s00296-006-0259-4 PubMedCrossRef

57.

de Gannes GC, Ghoreishi M, Pope J, Russell A, Bell D, Adams S, Shojania K, Martinka M, Dutz JP (2007) Psoriasis and pustular dermatitis triggered by TNF-α inhibitors in patients with rheumatologic conditions. Arch Dermatol 143:223–231. doi:10.1001/archderm.143.2.223 PubMedCrossRef

58.

Lee HH, Song IH, Friedrich M, Gauliard A, Deter J, Rowert J, Audring H, Kary S, Burmester GR, Sterry W, Worm M (2007) Cutaneous side-effects in patients with rheumatic diseases during application of tumor necrosis factor-α antagonists. Br J Dermatol 156:486–491. doi:10.1111/j.1365-2133.2007.07682.x PubMedCrossRef

Titel: Cutaneous manifestations associated with rheumatoid arthritis
verfasst von: T. Yamamoto
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 9/2009
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0881-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Intervallfasten zur Regeneration des Herzmuskels?

14.05.2024 Herzinfarkt Nachrichten

Die Nahrungsaufnahme auf wenige Stunden am Tag zu beschränken, hat möglicherweise einen günstigen Einfluss auf die Prognose nach akutem ST-Hebungsinfarkt. Darauf deutet eine Studie an der Uniklinik in Halle an der Saale hin.

Klimaschutz beginnt bei der Wahl des Inhalators

14.05.2024 Klimawandel Podcast

Auch kleine Entscheidungen im Alltag einer Praxis können einen großen Beitrag zum Klimaschutz leisten. Die neue Leitlinie zur "klimabewussten Verordnung von Inhalativa" geht mit gutem Beispiel voran, denn der Wechsel vom klimaschädlichen Dosieraerosol zum Pulverinhalator spart viele Tonnen CO₂. Leitlinienautor PD Dr. Guido Schmiemann erklärt, warum nicht nur die Umwelt, sondern auch Patientinnen und Patienten davon profitieren.

Typ-2-Diabetes und Depression folgen oft aufeinander

14.05.2024 Typ-2-Diabetes Nachrichten

Menschen mit Typ-2-Diabetes sind überdurchschnittlich gefährdet, in den nächsten Jahren auch noch eine Depression zu entwickeln – und umgekehrt. Besonders ausgeprägt ist die Wechselbeziehung laut GKV-Daten bei jüngeren Erwachsenen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 9/2009

Neurological complications of ankylosing spondylitis: neurophysiological assessment

Factors affecting bone mineral density in men

Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature

Clinical associations of anti-CENP-B and anti-Scl70 antibody levels measured by multiplexed fluorescent microsphere immunoassay in systemic sclerosis

Acute rheumatic fever in adults: case report together with an analysis of 25 patients with acute rheumatic fever