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Breast Cancer Research

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01.02.2001 | Commentary

Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models

verfasst von: Robert L Sutherland, Elizabeth A Musgrove

Erschienen in: Breast Cancer Research | Ausgabe 1/2001

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Abstract

Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer, with 45–50% of primary ductal carcinomas overexpressing this oncoprotein. Targeted deletion of the gene encoding cyclin D1 demonstrates an essential role in normal mammary gland development while transgenic studies provide evidence that cyclin D1 is a weak oncogene in mammary epithelium. In a recent exciting development, Yu et al. demonstrate that cyclin D1-deficient mice are resistant to mammary carcinomas induced by c-neu and v-Ha-ras, but not those induced by c-myc or Wnt-1. These findings define a pivotal role for cyclin D1 in a subset of mammary cancers in mice and imply a functional role for cyclin D1 overexpression in human breast cancer.

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Titel: Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models
verfasst von: Robert L Sutherland
Elizabeth A Musgrove
Publikationsdatum: 01.02.2001
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 1/2001
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr411

Springer Medizin

Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models

Abstract

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