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01.12.2007 | Clinical Trial

CYP1B1 and predisposition to breast cancer in Poland

verfasst von: Joanna Matyjasik, Cezary Cybulski, Bartlomiej Masojć, Anna Jakubowska, Pablo Serrano-Fernandez, Bohdan Górski, Tadeusz Dębniak, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Elzbieta Złowocka, Steven Alexander Narod, Rodney Scott, Jan Lubinski

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2007

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Abstract

Background

The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.

Objective

We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.

Methods

We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene. Genotype and haplotype frequencies were compared in cases and controls.

Results

In combinations of the R48G, A119S and L432V SNPs, four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect. A large reduction in risk was observed for women who were homozygous for one of these four haplotypes (OR = 0.2; 95%; CI = 0.05–0.5; P = 0.001) compared to women who were homozygous for the most common haplotype. In contrast, women who were homozygous for the GTC haplotype were at increased risk (OR = 1.5; 95%; CI = 1.0–2.1; P = 0.03) compared to women with the most common haplotype.

Conclusions

The CYP1B1 gene appears to influence breast cancer susceptibility in Poland.

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Titel: CYP1B1 and predisposition to breast cancer in Poland
verfasst von: Joanna Matyjasik
Cezary Cybulski
Bartlomiej Masojć
Anna Jakubowska
Pablo Serrano-Fernandez
Bohdan Górski
Tadeusz Dębniak
Tomasz Huzarski
Tomasz Byrski
Jacek Gronwald
Elzbieta Złowocka
Steven Alexander Narod
Rodney Scott
Jan Lubinski
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 3/2007
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9500-4

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CYP1B1 and predisposition to breast cancer in Poland