Introduction
Materials and methods
Patients
Immunohistochemistry
Imaging and data analysis
Statistical analysis
Patient characteristics
Clinicopathological parameter |
N (%) |
---|---|
Age (years) | |
≤48 | 66 (50.8) |
>48 | 64 (49.2) |
Menstrual status | |
Premenopausal | 82 (63.1) |
Postmenopausal | 48 (36.9) |
Pathological type | |
Invasive ductal carcinoma | 120 (92.3) |
Invasive lobular carcinoma | 2 (1.5) |
Medullary carcinoma | 3 (2.3) |
Mucinous carcinoma | 2 (1.5) |
Invasive eczematous carcinoma of nippla | 2 (1.5) |
Invasive ductal carcinoma and invasive lobular carcinoma | 1 (0.8) |
Tumor size | |
T1 | 47 (36.2) |
T2 | 70 (53.8) |
T3 | 11 (8.5) |
T4 | 2 (1.5) |
Lymph node metastasis | |
N0 | 63 (48.5) |
N1 | 39 (30.0) |
N2 | 13 (10.0) |
N3 | 15 (11.5) |
Clinical stage | |
I | 31 (23.8) |
IIA | 42 (32.3) |
IIB | 24 (18.5) |
IIIA | 16 (12.3) |
IIIB | 2 (1.5) |
IIIC | 15 (11.5) |
SBR grading | |
I | 17 (13.1) |
II | 89 (68.5) |
III | 24 (18.5) |
Thrombosis | |
Positive | 30 (23.1) |
Negative | 100 (76.9) |
ER | |
Positive | 84 (64.6) |
Negative | 46 (35.4) |
PR | |
Positive | 74 (56.9) |
Negative | 56 (43.1) |
HER-2 | |
Positive | 27 (20.8) |
Negative | 103 (79.2) |
Adjuvant chemotherapy | |
Yes | 104 (80.0) |
No | 26 (20.0) |
Adjuvant radiotherapy | |
Yes | 80 (61.5) |
No | 50 (38.5) |
Adjuvant endocrine therapy | |
Yes | 71 (54.6) |
No | 59 (45.4) |
CTLA-4 expression in breast cancer
Prognostic factors for DFS and OS in breast cancer
CTLA-4 expression and its correlation with clinicopathological features
Correlation between CTLA-4 expression and DFS or OS
Parameter | Basis for grouping | Number | DFS | OS | ||||
---|---|---|---|---|---|---|---|---|
Recurrences | Mean DFS (month) |
P value | Deaths | Mean OS (month) |
P value | |||
Density of interstitial CTLA-4+ lymphocytes | ≤33.44/mm2
| 57 | 22 | 103.383 | 0.002 | 20 | 108.629 | 0.004 |
>33.44/mm2
| 73 | 11 | 124.899 | 9 | 127.829 | |||
Tumor CTLA-4 expression | ≤1.525 | 82 | 17 | 126.029 | 0.088 | 14 | 124.771 | 0.041 |
>1.525 | 48 | 16 | 103.607 | 15 | 110.287 |
Survival by CTLA-4 expression in tumor cells and density of primary tumor CTLA-4+ interstitial lymphocytes
Groups | Tumor CTLA-4 expression | Density of interstitial CTLA-4+ lymphocytes | Number | Recurrences | Mean DFS (month) | Deaths | Mean OS (month) |
---|---|---|---|---|---|---|---|
Group 1 | ≤1.525 | >33.44/mm2
| 45 | 3 | 133.332 | 2 | 134.782 |
Group 2 | >1.525 | >33.44/mm2
| 28 | 8 | 107.649 | 7 | 114.033 |
Group 3 | ≤1.525 | ≤33.44/mm2
| 37 | 14 | 105.984 | 12 | 112.736 |
Group 4 | >1.525 | ≤33.44/mm2
| 20 | 8 | 92.265 | 8 | 101.322 |