Skip to main content
Erschienen in: Der Urologe 9/2005

01.09.2005 | Leitthema

Das Nachsorgeprinzip beim metastasierten Prostatakarzinom

Wenig Diagnostik, viel Support

verfasst von: K. Heine, Prof. Dr. J. M. Wolff

Erschienen in: Die Urologie | Ausgabe 9/2005

Einloggen, um Zugang zu erhalten

Zusammenfassung

Im Stadium des fortgeschrittenen PCA — abgesehen bei intermittierenden Strategien — befindet sich der Patient in ständiger Behandlung. Er muss zur Prüfung der Therapiewirkung engmaschig nachkontrolliert werden, damit beim Versagen der aktuellen Therapie schnellstmöglich zu einem anderen Regime gewechselt werden kann. Weil die Progression der Erkrankung in den meisten Fällen jedoch unaufhaltsam ist, besteht das Ziel der Therapie darin, die Lebensqualität des Patienten auf dem höchsten Niveau zu erhalten. Um den Patienten — wenn möglich — in seiner häuslichen Umgebung therapeutisch zu begleiten, sollten supportive Therapien eingesetzt werden, wie der Ausgleich einer Anämie oder die bedarfsangepasste Schmerzmedikation. Durch die Gabe von Bisphosphonaten kann etwaigen Skelettkomplikationen vorgebeugt werden.
Literatur
1.
Zurück zum Zitat Algra PR, Bloem JL, Tissing H, Falke TH, Arndt JW, Verboom LJ (1991) Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy. Radiographics 11(2): 219–232PubMed Algra PR, Bloem JL, Tissing H, Falke TH, Arndt JW, Verboom LJ (1991) Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy. Radiographics 11(2): 219–232PubMed
2.
Zurück zum Zitat Coleman RE, Ourohit OP, Vinholes JJ, Zekri J (1997) High-dose pamidronate: clinical and biochemical effects in metastatic bone disease. Cancer 80: 1652–1660CrossRefPubMed Coleman RE, Ourohit OP, Vinholes JJ, Zekri J (1997) High-dose pamidronate: clinical and biochemical effects in metastatic bone disease. Cancer 80: 1652–1660CrossRefPubMed
3.
Zurück zum Zitat Dearnaley DP, Sydes MR, Mason MD et al. (2003) A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PRO Trial). J Natl Cancer Inst 95: 1300–1311PubMed Dearnaley DP, Sydes MR, Mason MD et al. (2003) A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PRO Trial). J Natl Cancer Inst 95: 1300–1311PubMed
4.
Zurück zum Zitat Diamond TH, Winters J, Smith A et al. (2001) The antiosteoporotic efficacy of intravenous pamidronate in men with prostate carcinoma receiving combined androgen blockade. Cancer 92: 1444–1450CrossRefPubMed Diamond TH, Winters J, Smith A et al. (2001) The antiosteoporotic efficacy of intravenous pamidronate in men with prostate carcinoma receiving combined androgen blockade. Cancer 92: 1444–1450CrossRefPubMed
5.
Zurück zum Zitat Dunst J, Kuhnt T et al. (2003) Anaemia in cervical cancers: patterns of relapse and association with tumor hypoxia and angiogenesis. Int J Radiat Oncol Biol Phys 56(3): 778–787CrossRefPubMed Dunst J, Kuhnt T et al. (2003) Anaemia in cervical cancers: patterns of relapse and association with tumor hypoxia and angiogenesis. Int J Radiat Oncol Biol Phys 56(3): 778–787CrossRefPubMed
6.
Zurück zum Zitat Dupont A, Cusan L et al. (1991) Prostate specific antigen and prostatic acid phosphatase for monitoring therapy of carcinoma of the prostate. J Urol 146: 1064–1067PubMed Dupont A, Cusan L et al. (1991) Prostate specific antigen and prostatic acid phosphatase for monitoring therapy of carcinoma of the prostate. J Urol 146: 1064–1067PubMed
7.
Zurück zum Zitat Ercole CJ, Lange PH et al. (1987) Prostatic specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer. J Urol 138: 1181–1184PubMed Ercole CJ, Lange PH et al. (1987) Prostatic specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer. J Urol 138: 1181–1184PubMed
8.
Zurück zum Zitat Flynn DF, Shipley WU (1991) Management of spinal cord compression secondary to metastatic prostatic carcinoma. Urol Clin North Am 18(1): 145–152PubMed Flynn DF, Shipley WU (1991) Management of spinal cord compression secondary to metastatic prostatic carcinoma. Urol Clin North Am 18(1): 145–152PubMed
9.
Zurück zum Zitat Frommhold H, Guttenberger R, Henke M (1998) The impact of blood haemoglobin content on the outcome of radiotherapy. Strahlenther Onkol 174 [Suppl IV]: 31–34 Frommhold H, Guttenberger R, Henke M (1998) The impact of blood haemoglobin content on the outcome of radiotherapy. Strahlenther Onkol 174 [Suppl IV]: 31–34
10.
Zurück zum Zitat Greenberg MS (2004) Intravenous bisphosphonates and osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98(3): 259–260CrossRefPubMed Greenberg MS (2004) Intravenous bisphosphonates and osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98(3): 259–260CrossRefPubMed
11.
Zurück zum Zitat Grogan M, Thomas GM et al. (1999) The importance of maintaining high hemoglobin levels during radiation treatment of the carcinoma of the cervix. Cancer 86: 1531–1536CrossRef Grogan M, Thomas GM et al. (1999) The importance of maintaining high hemoglobin levels during radiation treatment of the carcinoma of the cervix. Cancer 86: 1531–1536CrossRef
12.
Zurück zum Zitat Heidenreich A, Hofmann R, Engelmann UH (2001) The use of bisphosphonate for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer. J Urol 165: 136–140CrossRefPubMed Heidenreich A, Hofmann R, Engelmann UH (2001) The use of bisphosphonate for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer. J Urol 165: 136–140CrossRefPubMed
13.
Zurück zum Zitat Henke M, Laszig R, Rube C et al. (2003) Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy : randomized, double-blind, placebo-controlled trial. Lancet 362 (9392): 1255–1260CrossRefPubMed Henke M, Laszig R, Rube C et al. (2003) Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy : randomized, double-blind, placebo-controlled trial. Lancet 362 (9392): 1255–1260CrossRefPubMed
14.
Zurück zum Zitat Huddart RA, Rajan B, Law M, Meyer L, Dearnaley DP (1997) Spinal cord compression in prostate cancer: treatment outcome and prognostic factors. Radiother Oncol 44(3): 229–236CrossRefPubMed Huddart RA, Rajan B, Law M, Meyer L, Dearnaley DP (1997) Spinal cord compression in prostate cancer: treatment outcome and prognostic factors. Radiother Oncol 44(3): 229–236CrossRefPubMed
15.
Zurück zum Zitat Iacovou JW, Marks JC, Abrams PH, Gingell JC, Ball AJ (1985) Cord compression and carcinoma of the prostate: is laminectomy justified? Br J Urol 57(6): 733–736PubMed Iacovou JW, Marks JC, Abrams PH, Gingell JC, Ball AJ (1985) Cord compression and carcinoma of the prostate: is laminectomy justified? Br J Urol 57(6): 733–736PubMed
16.
Zurück zum Zitat Kelly WK, Scher HI, Mazumdar M et al. (1993) Prostate-specific antigen as a measure of disease outcome in metastatic hormone-refractory prostate cancer. J Clin Oncol 11: 607–615PubMed Kelly WK, Scher HI, Mazumdar M et al. (1993) Prostate-specific antigen as a measure of disease outcome in metastatic hormone-refractory prostate cancer. J Clin Oncol 11: 607–615PubMed
17.
Zurück zum Zitat Kuban DA, El-Mahdi AM, Sigfred SV (1986) Characteristics of spinal cord compression in adenocarcinoma of prostate. Urology 18: 364–369CrossRef Kuban DA, El-Mahdi AM, Sigfred SV (1986) Characteristics of spinal cord compression in adenocarcinoma of prostate. Urology 18: 364–369CrossRef
18.
Zurück zum Zitat Leo ME, Bilhartz DL, Bergstralh, Oesterling JE (1991) Prostate specific antigen in hormonally treated stage D2 prostate cancer: is it always an accurate indicator of disease status? J Urol 145: 802–806PubMed Leo ME, Bilhartz DL, Bergstralh, Oesterling JE (1991) Prostate specific antigen in hormonally treated stage D2 prostate cancer: is it always an accurate indicator of disease status? J Urol 145: 802–806PubMed
19.
Zurück zum Zitat Lipton A, Glover D, Harvey H et al. (1994) Pamidronate in the treatment of bone metastases: results of 2 dose ranging trials in patients with breast and prostate cancer. Ann Oncol 5: S31–S35PubMed Lipton A, Glover D, Harvey H et al. (1994) Pamidronate in the treatment of bone metastases: results of 2 dose ranging trials in patients with breast and prostate cancer. Ann Oncol 5: S31–S35PubMed
20.
Zurück zum Zitat Lissoni P, Rovelli F et al. (2001) A Pase II study of s.c.low-dose IL2 plus Erythropoietin in metastatic renal cell carcinoma progressing on IL2 allone. Anticancer Res 21: 777–779PubMed Lissoni P, Rovelli F et al. (2001) A Pase II study of s.c.low-dose IL2 plus Erythropoietin in metastatic renal cell carcinoma progressing on IL2 allone. Anticancer Res 21: 777–779PubMed
21.
Zurück zum Zitat Littlewood TJ, Bajetta E et al. (2001) Effects of epoetin alfa on heamatologic parameters and qualità of life in cancer patients receiving nonplatinum chemotherapy. J Clin Oncol 19: 2865–2874PubMed Littlewood TJ, Bajetta E et al. (2001) Effects of epoetin alfa on heamatologic parameters and qualità of life in cancer patients receiving nonplatinum chemotherapy. J Clin Oncol 19: 2865–2874PubMed
22.
Zurück zum Zitat Messing EM, Thompson I Jr (2003) Follow Up of conservatively managed prostate cancer — wachtful waiting and primary hormonal therapy. Urol Clin N Am 30: 687–702CrossRef Messing EM, Thompson I Jr (2003) Follow Up of conservatively managed prostate cancer — wachtful waiting and primary hormonal therapy. Urol Clin N Am 30: 687–702CrossRef
23.
Zurück zum Zitat Migliorati CA, Schubert MM, Peterson DE, Seneda LM (2005) Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone. Cancer 104: 83–93CrossRefPubMed Migliorati CA, Schubert MM, Peterson DE, Seneda LM (2005) Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone. Cancer 104: 83–93CrossRefPubMed
24.
Zurück zum Zitat Mittelman M, Zeidman A et al. (2004) Erythropoietin has an antimyeloma effect — a hypothesis based on a clinical observation supported by animal studys. Eur J Haematol 72: 155–165CrossRefPubMed Mittelman M, Zeidman A et al. (2004) Erythropoietin has an antimyeloma effect — a hypothesis based on a clinical observation supported by animal studys. Eur J Haematol 72: 155–165CrossRefPubMed
25.
Zurück zum Zitat Modic MT, Masaryk T, Paushter D (1986) Magnetic resonance imaging of the spine. Radiol Clin North Am 24(2): 229–245PubMed Modic MT, Masaryk T, Paushter D (1986) Magnetic resonance imaging of the spine. Radiol Clin North Am 24(2): 229–245PubMed
26.
Zurück zum Zitat Nowrousian MR (2000) Pathophysiologie der tumorbedingten oder chemotherapieinduzierten Anämie. In: Nowrousian MR (Hrsg) Supportive Therapie in der Onkologie. Zuckschwerdt, München, S 84–98 Nowrousian MR (2000) Pathophysiologie der tumorbedingten oder chemotherapieinduzierten Anämie. In: Nowrousian MR (Hrsg) Supportive Therapie in der Onkologie. Zuckschwerdt, München, S 84–98
27.
Zurück zum Zitat Nowrousian MR (2002) Pathophysiology of cancer related anaemia. In: Nowrousian MR (ed) Recombinant Human Erythropoietin(rhEPO) in clinical oncology — scientific and clinical aspects of anaemia in cancer. Springer, Wien, pp 39–62 Nowrousian MR (2002) Pathophysiology of cancer related anaemia. In: Nowrousian MR (ed) Recombinant Human Erythropoietin(rhEPO) in clinical oncology — scientific and clinical aspects of anaemia in cancer. Springer, Wien, pp 39–62
28.
Zurück zum Zitat Oefelein MG, Richuiti V, Conrad W et al. (2001) Skeletal fracture rate associated with androgen supression induced osteoporosis: the clinical incidence and risk factors for patients with prostate cancer. J Urol 166: 1724–1728CrossRefPubMed Oefelein MG, Richuiti V, Conrad W et al. (2001) Skeletal fracture rate associated with androgen supression induced osteoporosis: the clinical incidence and risk factors for patients with prostate cancer. J Urol 166: 1724–1728CrossRefPubMed
29.
Zurück zum Zitat Österborg A, Brandberg Y et al. (2002) Randomized double-blind, placebo controlled trial of recombinant human erythropoietin, epoetin beta, in hematologic malignancies. J Clin Oncol 20: 2486–2494 Österborg A, Brandberg Y et al. (2002) Randomized double-blind, placebo controlled trial of recombinant human erythropoietin, epoetin beta, in hematologic malignancies. J Clin Oncol 20: 2486–2494
30.
Zurück zum Zitat Orwoll E, Ettinger M, Weiss S et al. (2000) Alendronate for the treatment of osteoporosis in men. New Engl J Med 343: 604–610CrossRefPubMed Orwoll E, Ettinger M, Weiss S et al. (2000) Alendronate for the treatment of osteoporosis in men. New Engl J Med 343: 604–610CrossRefPubMed
31.
Zurück zum Zitat Osborn JL, Getzenberg RH, Trump DL (1995) Spinal cord compression in prostate cancer. J Neurooncol 23: 135–147CrossRefPubMed Osborn JL, Getzenberg RH, Trump DL (1995) Spinal cord compression in prostate cancer. J Neurooncol 23: 135–147CrossRefPubMed
32.
Zurück zum Zitat Petrylak DP, Scher HI, Li Z, Myers CE, Geller NL (1992) Prognostic factors for survival of patients with bidimensionally measurable metastatic hormone refractory prostate cancer treated with single-agent chemotherapy. Cancer 70(12): 2870–2878PubMed Petrylak DP, Scher HI, Li Z, Myers CE, Geller NL (1992) Prognostic factors for survival of patients with bidimensionally measurable metastatic hormone refractory prostate cancer treated with single-agent chemotherapy. Cancer 70(12): 2870–2878PubMed
33.
Zurück zum Zitat Rubin H, Lome LG, Presman D (1974) Neurological manifestations of metastatic prostate carcinoma. J Urol 111: 799–802PubMed Rubin H, Lome LG, Presman D (1974) Neurological manifestations of metastatic prostate carcinoma. J Urol 111: 799–802PubMed
34.
Zurück zum Zitat Rubins J (1995) Metastatic renal cell carcinoma: response to treatment with human recombinant erythropoietin. Ann Intern Med 122: 676–677PubMed Rubins J (1995) Metastatic renal cell carcinoma: response to treatment with human recombinant erythropoietin. Ann Intern Med 122: 676–677PubMed
35.
Zurück zum Zitat Rudat V, Dietz A et al. (1999) Prognostic impact of total tumor volume and hemoglobin concentration on the outcome of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol 53: 119–125CrossRefPubMed Rudat V, Dietz A et al. (1999) Prognostic impact of total tumor volume and hemoglobin concentration on the outcome of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol 53: 119–125CrossRefPubMed
36.
Zurück zum Zitat Saad F, Gleason DM, Murray R et al. (2002) A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94: 1458–1468PubMed Saad F, Gleason DM, Murray R et al. (2002) A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94: 1458–1468PubMed
37.
Zurück zum Zitat Silver DF, Piver MS (1999) Effects of recombinant human erythropoietin on the antitumor effect of cisplatin in SCID mice bearing human ovarian cancer. Gynecol Oncol 73: 280–284CrossRefPubMed Silver DF, Piver MS (1999) Effects of recombinant human erythropoietin on the antitumor effect of cisplatin in SCID mice bearing human ovarian cancer. Gynecol Oncol 73: 280–284CrossRefPubMed
38.
Zurück zum Zitat Smith DC, Vogelzang NJ, Goldberg HL et al. (1993) High dose cyclophosphamide (CTX) with granulocyte-macrophage stimulating factor (GM-CSF) in hormone refractory prostate carcinoma. Proc Am Soc Clin Oncol 11: 213 Smith DC, Vogelzang NJ, Goldberg HL et al. (1993) High dose cyclophosphamide (CTX) with granulocyte-macrophage stimulating factor (GM-CSF) in hormone refractory prostate carcinoma. Proc Am Soc Clin Oncol 11: 213
39.
Zurück zum Zitat Smith JA Jr, Lange PH et al. (1997) Serum markers as apredictor of response duration and patients survival after hormonal therapy for metastatic carcinoma of the prostate. J Urol 157: 1329–1334CrossRefPubMed Smith JA Jr, Lange PH et al. (1997) Serum markers as apredictor of response duration and patients survival after hormonal therapy for metastatic carcinoma of the prostate. J Urol 157: 1329–1334CrossRefPubMed
40.
Zurück zum Zitat Smith MR (2002) Osteoporosis and other adverse body composition changes during androgen deprivation therapy for prostate cancer. Cancer Metastasis Rev 21: 159–166CrossRefPubMed Smith MR (2002) Osteoporosis and other adverse body composition changes during androgen deprivation therapy for prostate cancer. Cancer Metastasis Rev 21: 159–166CrossRefPubMed
41.
Zurück zum Zitat Smith MR, McGovern FJ, Zietman AL et al. (2001) Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. New Engl J Med 345: 989–991CrossRefPubMed Smith MR, McGovern FJ, Zietman AL et al. (2001) Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. New Engl J Med 345: 989–991CrossRefPubMed
42.
Zurück zum Zitat Smith M et al. (2003) Randomised controlled trial of zoledronic acid to prevent boneloss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 169: 2008–2012CrossRefPubMed Smith M et al. (2003) Randomised controlled trial of zoledronic acid to prevent boneloss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 169: 2008–2012CrossRefPubMed
43.
Zurück zum Zitat Smith MR, Eastham J, Gleason DM et al. (2003) Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 170: 2392–2393CrossRef Smith MR, Eastham J, Gleason DM et al. (2003) Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 170: 2392–2393CrossRef
44.
Zurück zum Zitat Stüben G, Thews O, Pottgen C et al. (2001) Recombinant Human Erythropoietin increases the radiosensitivity of xenografted human tumors in anaemic nude mice. J Cancer Res Clin Oncol 127: 346–350CrossRefPubMed Stüben G, Thews O, Pottgen C et al. (2001) Recombinant Human Erythropoietin increases the radiosensitivity of xenografted human tumors in anaemic nude mice. J Cancer Res Clin Oncol 127: 346–350CrossRefPubMed
45.
Zurück zum Zitat Tarnawski R, Skladowski K et al. (1997) Prognostic value of hemoglobin concentration in radiotherapy for cancer of the supraglottic larynx. Int Radiat Oncol Biol Phys 38: 1007–1011CrossRef Tarnawski R, Skladowski K et al. (1997) Prognostic value of hemoglobin concentration in radiotherapy for cancer of the supraglottic larynx. Int Radiat Oncol Biol Phys 38: 1007–1011CrossRef
46.
Zurück zum Zitat Thews O, König R et al. (1998) Enhanced radiosensitivity in experimental tumors following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer 78: 752–56PubMed Thews O, König R et al. (1998) Enhanced radiosensitivity in experimental tumors following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer 78: 752–56PubMed
47.
Zurück zum Zitat Thews O, Kelleher DK, Vaupel P (2001) Erythropoietin restores the anaemia-induced reduction in cyclophosphamid toxicity in rat tumors. Cancer Res 61: 1358–1361PubMed Thews O, Kelleher DK, Vaupel P (2001) Erythropoietin restores the anaemia-induced reduction in cyclophosphamid toxicity in rat tumors. Cancer Res 61: 1358–1361PubMed
48.
Zurück zum Zitat Werner-Wasik M, Scott C, Cox JD et al. (2000) Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patient swith locally advanced non-small-cell-lung cancer (LA-NSCLC): identification of 5 groups with different survival. Int Radiat Oncol Biol Phys 48: 1475–1482CrossRef Werner-Wasik M, Scott C, Cox JD et al. (2000) Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patient swith locally advanced non-small-cell-lung cancer (LA-NSCLC): identification of 5 groups with different survival. Int Radiat Oncol Biol Phys 48: 1475–1482CrossRef
49.
Zurück zum Zitat Yao Siu-Long, DiPaola RS (2003) An evidence-based approach to prostate cancer follow-up. Semin Oncol 30(3): 390–400CrossRefPubMed Yao Siu-Long, DiPaola RS (2003) An evidence-based approach to prostate cancer follow-up. Semin Oncol 30(3): 390–400CrossRefPubMed
Metadaten
Titel
Das Nachsorgeprinzip beim metastasierten Prostatakarzinom
Wenig Diagnostik, viel Support
verfasst von
K. Heine
Prof. Dr. J. M. Wolff
Publikationsdatum
01.09.2005
Verlag
Springer-Verlag
Erschienen in
Die Urologie / Ausgabe 9/2005
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-005-0885-6

Weitere Artikel der Ausgabe 9/2005

Der Urologe 9/2005 Zur Ausgabe

Mitteilungen der DGU

Mitteilungen der DGU

Weiterbildung · Zertifizierte Fortbildung

Harnblasentumoren

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

Stufenschema weist Prostatakarzinom zuverlässig nach

22.04.2024 Prostatakarzinom Nachrichten

Erst PSA-Test, dann Kallikrein-Score, schließlich MRT und Biopsie – ein vierstufiges Screening-Schema kann die Zahl der unnötigen Prostatabiopsien erheblich reduzieren: Die Hälfte der Männer, die in einer finnischen Studie eine Biopsie benötigten, hatte einen hochgradigen Tumor.

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

20.04.2024 EAU 2024 Kongressbericht

Beim chronischen Harnwegsinfekt bei Frauen wird bisher meist eine Antibiotikaprophylaxe eingesetzt. Angesichts der zunehmenden Antibiotikaresistenz erweist sich das Antiseptikum Methenamin-Hippurat als vielversprechende Alternative, so die Auswertung einer randomisierten kontrollierten Studie.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.