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05.01.2021 | Original Paper

Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease

verfasst von: Niharika Srivastava, Anuradha Bishnoi, Davinder Parsad, Muthu Sendhil Kumaran, Keshavamurthy Vinay, Sarika Gupta

Erschienen in: Archives of Dermatological Research | Ausgabe 9/2021

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Abstract

In autoimmune onset of vitiligo, perilesional area shows inflammatory cells including T cytotoxic, helper cells and macrophages. Dendritic Cells (DCs) regulate immune activities by antigen presentation to T cells or cytokine production. It is evident that pro- and anti-inflammatory DCs are responsible for their respective cytokines release. However, role of DCs in vitiligo is enigmatic. In the present study, we assessed DCs markers (CD11b and CD11c) along with pro- and anti-inflammatory cytokines (IL-17A, IL-10 and IL-12p70) in stable and active vitiligo patients. Our results revealed a significant augmented expression of CD11b⁺CD11c⁺ (pro-inflammatory DC) in peripheral blood mononuclear cells (PBMCs) and skin tissues of active vitiligo patients versus control and stable vitiligo group. Unlikely, CD11b⁺ (anti-inflammatory DC) levels were significantly impeded in active vitiligo group as compared to another two groups. CD11c (T helper 1 stimulating DC) presented no significant alterations in any group. Furthermore, we perceived significantly up-regulated IL-17A (pro-inflammatory cytokine) and down-regulated IL-10 (anti-inflammatory cytokine) expressions in active vitiligo group as compared to control and stable group (in sera, PBMCs and skin tissue). Also, a significant positive correlation was observed between CD11b⁺CD11c⁺ and IL-17A; and CD11b⁺ and IL-10. Contrarily, CD11b⁺CD11c⁺ and CD11b⁺ were negatively correlated with IL-10 and IL-17A, respectively. In conclusion, modulation of pro- and anti-inflammatory DCs in active vitiligo patients may affect cytokines production and thereby, lead to further depigmentation of skin.

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Titel: Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease
verfasst von: Niharika Srivastava
Anuradha Bishnoi
Davinder Parsad
Muthu Sendhil Kumaran
Keshavamurthy Vinay
Sarika Gupta
Publikationsdatum: 05.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 9/2021
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-020-02168-w

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