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01.04.2014 | Original Article

Development and validation of nomograms to predict the recovery of urinary continence after radical prostatectomy: comparisons between immediate, early, and late continence

verfasst von: Seong Jin Jeong, Jae Seung Yeon, Jeong Keun Lee, Woo Heon Cha, Jin Woo Jeong, Byung Ki Lee, Sang Cheol Lee, Chang Wook Jeong, Jeong Hyun Kim, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee

Erschienen in: World Journal of Urology | Ausgabe 2/2014

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Abstract

Purpose

Few studies have been conducted on the serial evaluation of predictors for recovery of urinary continence (RC) after radical prostatectomy (RP) among same cohort. We developed and validated nomograms to predict immediate (≤1), early (≤3), and late (≤12 months) RC from a contemporary series and compared each nomogram with regard to the significance of predictors for RC.

Methods

Among consecutive men who received robot-assisted or open retropubic RP between 2004 and 2011, 872 (74.7 %) and 296 (25.3 %) were randomly assigned to subcohorts for the development of nomograms and for the split-sample external validation. The final multivariate model was selected based on the stepwise procedure, and the regression coefficient-based nomograms were developed based on final models.

Results

Age at surgery, membranous urethral length (MUL), and robot-assisted RP were significant for RC at 1, 3, and 12 months. Saving the neurovascular bundle (NVB) and prostate volume were significant only for RC at 12 months. Odds ratios for age and MUL were constant over time, whereas the odds ratio for robot-assisted surgery decreased over time. Each developed nomogram was reasonably well fitted to the ideal line of the calibration plot. The split-sample external validation of nomograms indicated 63, 65, 71 % accuracy for each RC time point.

Conclusions

We developed nomograms for RC at each time point after RP and validated adequately. Saving the NVB and prostate volume may affect only late RC after RP. In contrast, age, MUL, and robot-assisted surgery seem to be consistently associated with immediate, early, and late RC.

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Titel: Development and validation of nomograms to predict the recovery of urinary continence after radical prostatectomy: comparisons between immediate, early, and late continence
verfasst von: Seong Jin Jeong
Jae Seung Yeon
Jeong Keun Lee
Woo Heon Cha
Jin Woo Jeong
Byung Ki Lee
Sang Cheol Lee
Chang Wook Jeong
Jeong Hyun Kim
Sung Kyu Hong
Seok-Soo Byun
Sang Eun Lee
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 2/2014
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-013-1127-y

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Development and validation of nomograms to predict the recovery of urinary continence after radical prostatectomy: comparisons between immediate, early, and late continence