Erschienen in:
01.11.2012 | Brief Report
Development of a minigenome system for Andes virus, a New World hantavirus
verfasst von:
Kyle S. Brown, Hideki Ebihara, Heinz Feldmann
Erschienen in:
Archives of Virology
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Ausgabe 11/2012
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Abstract
The development of reverse genetics systems for negative-stranded RNA viruses is a rapidly evolving field that has greatly advanced the study of the many different aspects of the viral life cycle. Andes virus (ANDV) is a highly pathogenic hantavirus found in South America that causes hantavirus pulmonary syndrome but to date remains poorly characterized due to the lack of a reverse genetics system for genetic manipulation. Here, we describe the first successful minigenome system for a New World hantavirus, as well as many of the obstacles that still exist in the development of such a system.