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01.12.2014 | Letter to the Editor | Ausgabe 1/2014 Open Access

Orphanet Journal of Rare Diseases 1/2014

Development of interactive algorithm for clinical management of acute events related to sickle cell disease in emergency department

Orphanet Journal of Rare Diseases > Ausgabe 1/2014
Gian Luca Forni, Gabriele Finco, Giovanna Graziadei, Manuela Balocco, Paolo Rigano, Silverio Perrotta, Oliviero Olivieri, Maria Domenica Cappellini, Lucia De Franceschi
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Electronic supplementary material

The online version of this article (doi:10.​1186/​1750-1172-9-91) contains supplementary material, which is available to authorized users.

Competing interests

The authors have nothing to disclose.


Sickle cell disease (SCD ORPHA232; OMIM 603903) is a rare hereditary red cell disorder, which global distribution is changed in the last decade due to immigration-fluxes from endemic areas to Western-countries. One of the main clinical manifestations of SCD are the acute painful vaso-occlusive crisis, which cause frequent accesses of SCD patients to the emergency departments (EDs). This has generated the requirement of feasible tools for emergency givers. In the context of the scientific-Italian-Society for the study of Thalassemias and Hemoglobinopathies (SITE), we developed an algorithm with interactive windows to guide physicians in managing SCD patients in EDs.
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