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Seminars in Immunopathology
Erschienen in: Seminars in Immunopathology 2/2018

06.11.2017 | Review

Dietary and metabolic modulators of hepatic immunity

verfasst von: Antonella Carambia, Johannes Herkel

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2018

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Abstract

The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver inflammation. The regulation of the delicate balance between liver tolerance and liver inflammation is of vital importance for the organism. In recent years, a general role for dietary components and metabolites as immune mediators has been emerging. However, although the liver is exposed to a great deal of metabolic mediators, surprisingly, little is known about their actual role in the regulation of hepatic immune responses. Here, we will explore the possible impacts of metabolic mediators for homoeostatic and pathological immunity in the liver, by highlighting selected examples of metabolic immune regulation in the liver.
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Metadaten
Titel
Dietary and metabolic modulators of hepatic immunity
verfasst von
Antonella Carambia
Johannes Herkel
Publikationsdatum
06.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Seminars in Immunopathology / Ausgabe 2/2018
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-017-0659-4

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