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Seminars in Immunopathology OnlineFirst articles

07.06.2019 | Review

The role of inflammation in diabetic eye disease

Mounting evidence suggests that immunological mechanisms play a fundamental role in the pathogenesis of diabetic retinopathy (DR) and diabetic macular edema (DME). Upregulation of cytokines and other proinflammatory mediators leading to persistent …

28.05.2019 | Review

Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?

The polycystic ovary syndrome (PCOS) is a frequent endocrine disorder in women of reproductive age. Its main characteristics are the ovarian overproduction of androgens and ovulatory dysfunction which lead to severe symptoms such as hirsutism …

17.05.2019 | Review

The role of interleukin-6 in glucose homeostasis and lipid metabolism

Low-grade inflammation is recognized as an important factor in the development and progression of a multitude of diseases including type 2 diabetes mellitus and cardiovascular disease. The potential of using antibody-based therapies that …

02.05.2019 | Review

Transcriptional control of macrophage polarisation in type 2 diabetes

Type-2 diabetes (T2D) is considered today as an inflammatory disease. Inflammatory processes in T2D are orchestrated by macrophage activation in different organs. Macrophages undergo classical M1 pro-inflammatory or alternative M2 …

25.04.2019 | Review

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

With obesity and type 2 diabetes prevalence steadily increasing and no effective means in sight to support the population in obtaining and maintaining stable weight loss, there is an imminent need for pharmacological therapy to treat and prevent …

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Seminars in Immunopathology helps clinicians and pathologists keep up-to-date on developments in the field of immunopathology. Guest editors help to organize issues devoted to a single topic. Review articles, by authors who have personally contributed to the topic, summarize new developments. Key references appear at the end of each paper, to provide interested readers with additional background material.

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