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Pediatric Radiology

Erschienen in:

01.11.2011 | Original Article

Diffusion tensor imaging evaluation of white matter in adolescents with myelomeningocele and Chiari II malformation

verfasst von: Xiawei Ou, Charles M. Glasier, Jeffrey H. Snow

Erschienen in: Pediatric Radiology | Ausgabe 11/2011

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Abstract

Background

Macrostructural abnormalities in cerebral white matter in patients with myelomeningocele are well known, but microstructural abnormalities are not as well studied.

Objective

The aim of this study was to evaluate cerebral white matter in adolescents with myelomeningocele using diffusion tensor imaging (DTI), and to investigate the effects of ventricular dilation and CSF shunt presence on white matter microstructure in these patients.

Materials and methods

DTI and T1-weighted 3-D (T1-3-D) MRI were performed on nine adolescents with myelomeningocele and Chiari II malformation and nine age-matched controls. The fractional anisotropy (FA) and mean diffusivity (MD) values were measured and compared.

Results

Significantly decreased FA and increased MD values were observed in most white matter regions and fibers in adolescents with myelomeningocele compared to controls. Further analysis in patients revealed significant changes in DTI parameters in hemispheres with enlarged lateral ventricles compared to those with normal ventricle size. In addition, a significant difference in FA values in the posterior limb of the internal capsule was found in the comparison of hemispheres in patients with or without CSF shunt catheters.

Conclusion

This study revealed widespread microstructural abnormalities in white matter in adolescents with myelomeningocele and Chiari II malformation. Ventricular dilation may have additional effects on white matter microstructure in this patient population. CSF shunt diversion effects on white matter may be multifactorial and need further investigation.

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Titel: Diffusion tensor imaging evaluation of white matter in adolescents with myelomeningocele and Chiari II malformation
verfasst von: Xiawei Ou
Charles M. Glasier
Jeffrey H. Snow
Publikationsdatum: 01.11.2011
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 11/2011
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-011-2180-6

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Diffusion tensor imaging evaluation of white matter in adolescents with myelomeningocele and Chiari II malformation

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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Background

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Materials and methods

Results

Conclusion

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