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Current Neurology and Neuroscience Reports

Erschienen in:

01.11.2013 | Demyelinating Disorders (DN Bourdette and V Yadav, Section Editors)

Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects

verfasst von: Ralf A. Linker, Ralf Gold

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 11/2013

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Abstract

Dimethyl fumarate is an orally available treatment option for relapsing–remitting multiple sclerosis (MS) in a new formulation with improved gastroenteric coating. The mode of action comprises immunomodulatory effects and an activation of nuclear (erythroid-derived 2) related factor mediated antioxidative response pathways leading to additional cytoprotective effects. In two pivotal phase III trials, dimethyl fumarate, 240 mg twice daily, reduced relapse rates by about 50 % as compared with placebo. In the DEFINE trial, progression of disability was also significantly reduced. Both trials demonstrated a significant reduction of gadolinium-enhanced lesions as well as T2 lesions on cranial MRI. The studies revealed a beneficial safety profile of dimethyl fumarate. The most prevalent side effects were transient flushing and gastrointestinal tract irritation. Dimethyl fumarate has recently been approved in the USA for the treatment of relapsing–remitting MS. The compound is a welcome addition to the immunomodulatory treatment armamentarium for MS patients and physicians alike.

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Titel: Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects
verfasst von: Ralf A. Linker
Ralf Gold
Publikationsdatum: 01.11.2013
Verlag: Springer US
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 11/2013
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-013-0394-8

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