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Pediatric Surgery International

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10.11.2018 | Original Article

Direct hyperbilirubinemia in newborns with gastroschisis

verfasst von: Sarah B. Cairo, Alex H. Osak, Sara K. Berkelhamer, Cara McLaughlin, David H. Rothstein

Erschienen in: Pediatric Surgery International | Ausgabe 3/2019

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Abstract

Background

Patients with gastroschisis and prolonged total (or partial) parenteral nutrition (PN) commonly develop direct hyperbilirubinemia (DH).

Objective

To quantify the prevalence and severity of DH in newborns with gastroschisis and characterize the diagnostic work-up for DH in this patient population.

Design/Methods

Retrospective chart review of patients born with gastroschisis between 2005 and 2015 for the first 6 months of life.

Results

29 patients were identified with gastroschisis. Mean gestational age and birthweight were 36.4 (± 1.8) weeks and 2.5 (± 0.6) kg. 41% were treated with primary reduction versus staged closure. Peak total and direct bilirubin (DB) levels were 10.17 ± 6.21 mg/dL and 5.58 ± 3.94 mg/dL, respectively. 23 patients (79.3%) were diagnosed with DH and 78.2% underwent additional work-up for hyperbilirubinemia consisting of imaging and laboratory studies, none of which revealed a cause for DH other than the presumed PN-associated cholestasis. In all patients, DB began to decline within 1–10 days of initiation of enteral feeds.

Conclusion(s)

DH is common in patients with gastroschisis and is unlikely to be associated with pathology aside from PN. Additional work-up may lead to unnecessary resource utilization.

Levels of evidence

Case series with no comparison group, Level IV.

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Titel: Direct hyperbilirubinemia in newborns with gastroschisis
verfasst von: Sarah B. Cairo
Alex H. Osak
Sara K. Berkelhamer
Cara McLaughlin
David H. Rothstein
Publikationsdatum: 10.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 3/2019
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4415-1

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Springer Medizin

Direct hyperbilirubinemia in newborns with gastroschisis

Abstract

Background

Objective

Design/Methods

Results

Conclusion(s)

Levels of evidence

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Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Häufigste Gründe für Brustschmerzen bei Kindern

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Update Pädiatrie

Springer Medizin

Abstract

Background

Objective

Design/Methods

Results

Conclusion(s)

Levels of evidence

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