Background
Methods
Study population
Measures
Disability
HRQOL measures
Comorbidity
Data analysis
HRQOL measure concordance
HRQOL discriminant ability
Results
Variable | Sample (N = 563) |
---|---|
Age (years), mean (SD) | 47.6 (11.1) |
Age of MS symptom onset (years), mean (SD) | 33.5 (10.3) |
Time since symptom onset (years), mean (SD) | 14.3 (9.9) |
Sex, N (%) | |
Female | 438 (77.8) |
Male | 125 (22.2) |
Race, N (%) | |
White | 523 (96.1) |
Non-White | 21 (3.9) |
Education, N (%) | |
High School or Lower | 149 (27.1) |
College or Trade | 212 (38.6) |
University or Higher | 188 (34.2) |
Marital Status, N (%) | |
Single | 71 (12.8) |
Married/Common Law | 415 (75.0) |
Widowed/Divorced/Separated | 67 (12.1) |
Employment Status, N (%) | |
Employed | 266 (48.2) |
Unemployed | 286 (51.8) |
Geographic Area, N (%) | |
Calgary | 237 (42.1) |
Edmonton | 176 (31.3) |
Central Alberta | 83 (14.7) |
Northern Alberta | 39 (6.9) |
Southern Alberta | 28 (5.0) |
Family History of MS, N (%) | |
Yes | 160 (30.0) |
No | 373 (70.0) |
Definite MS, N (%) | |
Yes | 525 (93.3) |
No | 8 (6.7) |
Disease Course, N (%)a
| |
RRMS | 363 (69.1) |
SPMS | 91 (17.3) |
PPMS | 50 (9.5) |
Uncertain | 21 (4.0) |
Disability Status (PDDS) | |
Normal | 143 (25.4) |
Mild | 127 (22.6) |
Moderate | 182 (32.3) |
Severe | 111 (19.7) |
DMT Use, N (%) | |
Never | 178 (32.1) |
Past | 95 (17.1) |
Current | 281 (50.7) |
Comorbidity | N (%) |
---|---|
Depression | 150 (26.6) |
Hypertension | 86 (15.3) |
Hyperlipidemia | 85 (15.1) |
Migraine | 84 (14.9) |
Lung Trouble | 49 (8.7) |
Thyroid Disease | 44 (7.8) |
Irritable Bowel Syndrome (IBS) | 42 (7.5) |
Osteoporosis | 42 (7.5) |
Anxiety Disorders | 38 (6.7) |
Cataracts | 24 (4.3) |
Diabetes | 20 (3.6) |
Heart Trouble | 14 (2.5) |
Inflammatory Bowel Disease (IBD) | 11 (2.0) |
Rheumatoid Arthritis | 11 (2.0) |
Fibromyalgia | 9 (1.6) |
Epilepsy | 7 (1.2) |
Bipolar Disorder | 6 (1.1) |
Glaucoma | 5 (0.9) |
Diseases of the Arteries | 4 (0.7) |
Lupus | 4 (0.7) |
Alcoholism | 3 (0.5) |
Parkinson’s Disease | 0 (0.0) |
Comorbidity
Disability
Dependent Variable | PCS-36 | MCS-36 | SF-6D | HUI-III | PCS-54 | MCS-54 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Independent Factor Variable | F-test | p-value | F-test | p-value | F-test | p-value | F-test | p-value | F-test | p-value | F-test | p-value |
Disability Status | 132.53 |
<0.0001
| 3.84 |
0.01
| 45.18 |
<0.0001
| 72.27 |
<0.0001
| 83.58 |
<0.0001
| 32.12 |
<0.0001
|
Normal vs. Mild | 12.68 |
<0.05
| 4.03 |
<0.05
| 9.94 |
<0.05
| 8.80 |
<0.05
| 11.98 |
<0.05
| 8.15 |
<0.05
|
Normal vs. Moderate | 26.72 |
<0.05
| 0.30 | NS | 13.69 |
<0.05
| 15.68 |
<0.05
| 19.71 |
<0.05
| 10.82 |
<0.05
|
Normal vs. Severe | 34.65 |
<0.05
| 0.67 | NS | 20.58 |
<0.05
| 26.93 |
<0.05
| 26.47 |
<0.05
| 16.98 |
<0.05
|
Mild vs. Moderate | 14.04 |
<0.05
| 4.33 |
<0.05
| 3.75 |
<0.05
| 6.88 |
<0.05
| 7.73 |
<0.05
| 2.67 | NS |
Mild vs. Severe | 21.96 |
<0.05
| 3.36 | NS | 10.64 |
<0.05
| 18.13 |
<0.05
| 14.48 |
<0.05
| 8.83 |
<0.05
|
Moderate vs. Severe | 7.93 |
<0.05
| 0.97 | NS | 6.90 |
<0.05
| 11.25 |
<0.05
| 6.75 |
<0.05
| 6.16 |
<0.05
|