Participating hospitals, local trial coordinators
Catharina Hospital, Eindhoven, prof. dr. B.C. Schoot.
Deventer Hospital, Deventer, dr. P.J.Q. van der Linden.
Diakonessenhuis, Utrecht, dr. K.L. Deurloo.
Groene Hart Hospital, Gouda, dr. C. Janssen.
Isala Fertility Clinic, Zwolle, dr. B.J. Cohlen.
Jeroen Bosch Hospital, ‘s Hertogenbosch, dr. J.P. de Bruin.
Laurentius Hospital, Roermond, drs. C. Lardenoije.
Maasstad Hospital, Rotterdam, dr. R. van Oppenraaij.
Maastricht University Medical Centre +, Maastricht, dr. J.E. den Hartog.
Máxima Medical Centre, Veldhoven, dr. J.W.M. Maas.
Meander Medical Centre, Amersfoort, drs. E.A. Brinkhuis.
St. Antonius Hospital, Nieuwegein, dr. J. van Disseldorp.
Tergooi Hospital, Hilversum, drs. H. Visser.
University Medical Centre Groningen, Groningen, dr. A. Cantineau.
Vrije Universiteit Medical Centre, Amsterdam, prof. dr. C.B. Lambalk.
Study population
Women from couples diagnosed with unexplained infertility and a Hunault of > 30%, who have been advised to continue timed intercourse during at least 6 months, are eligible. Inclusion criteria are as follows: female age between 18 and 38 years; primary or secondary infertility lasting at least 12 months; a regular menstrual cycle (defined as a mean cycle length of 21–35 days); at least one patent tube (diagnosed by negative Chlamydia antibody titre (CAT) and absence of risk factors for tubal disease, and/or diagnosed by hysterosalpingography or diagnostic laparoscopy); total motile sperm count > 3 million and a normal transvaginal ultrasound, which is defined as the absence of visible intracavitary pathology (e.g. polyps or intramural myomas with distortion of the uterine cavity). Exclusion criteria are: a history of lower abdominal or pelvic infection, a higher chance of intra-abdominal infection due to intestinal surgery, endometriosis grade 3 and 4, previous caesarean section with niche development, recurrent miscarriage (defined as ≥2 pregnancy losses prior to 20 weeks of gestation), the presence of untreated unilateral or bilateral hydrosalpinx, previous endometrial scratching, meno-metrorrhagia, and untreated endocrine disorders.