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01.12.2009 | Nephrology - Original Paper

Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities?

verfasst von: Ilknur Inegol Gumus, Ebru Uz, Nuket Bavbek, Ayse Kargili, Burcu Yanik, Faruk Hilmi Turgut, Ali Akcay, Nilgun Ozturk Turhan

Erschienen in: International Urology and Nephrology | Ausgabe 4/2009

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Abstract

Objectives

We aimed to investigate the glomerular hyperfiltration due to pregnancy in women with more parities.

Methods

Five hundred women aged 52.57 ± 8.08 years, without a history of hypertension, diabetes mellitus or complicated pregnancy were involved in the study. They were divided into three groups. Group 1: women with no or one parity (n = 76); group 2: women with two or three parities (n = 333); group 3: women with four or more parities (n = 91). Laboratory parameters and demographical data were compared between the three groups.

Results

Mean age, serum urea and serum creatinine were similar between three groups. Patients in group 3 had significantly higher GFR values compared to groups 1 and 2 (109.44 ± 30.99, 110.76 ± 30.22 and 121.92 ± 34.73 mL/min/1.73 m² for groups 1, 2 and 3, respectively; P = 0.008 for group 1 vs group 3; P = 0.002 for group 2 vs group 3).

Conclusions

In our study, we suggest that glomerular hyperfiltration due to pregnancy does not have adverse effects on kidney in women with more parities. Pregnancy may have possible protective mechanisms for kidney against adverse effects of glomerular hyperfiltration.

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Titel: Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities?
verfasst von: Ilknur Inegol Gumus
Ebru Uz
Nuket Bavbek
Ayse Kargili
Burcu Yanik
Faruk Hilmi Turgut
Ali Akcay
Nilgun Ozturk Turhan
Publikationsdatum: 01.12.2009
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 4/2009
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-009-9586-1

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