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Erschienen in:

01.08.2009 | Original Article

Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience

verfasst von: Osama Gheith, Ehab Wafa, Nabil Hassan, Amani Mostafa, Hussein A. Sheashaa, Khaled Mahmoud, Ahmed Shokeir, Mohamed A. Ghoneim

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 4/2009

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Abstract

Background/Aims

Posttransplantation anemia (PTA) frequently occurs. We aimed to assess the prevalence of anemia at 6 months of transplantation in patients under different protocols of immunosuppression, and to determine the impact of anemia on long-term patient and graft survival.

Methods

We included 832 renal transplant recipients who were categorized at 6 months according to hemoglobin (Hb) level into two groups: the first group, with Hb >13 g/dl in males and >12 g/dl in females (group I, 385 cases); and the second group, with Hb <13 g/dl in males and <12 g/dl in females (group II, 447 cases). We compared the two groups regarding posttransplant complications as well as patient and graft survival.

Results

Although there was no significant difference between the two groups regarding acute rejection episodes, chronic allograft nephropathy was significantly higher in the anemic group. Other posttransplant medical complications were comparable in both groups. Graft survival was significantly higher in the nonanemic group. However, no difference in patient survival was detected.

Conclusion

From this study, we can conclude that prevalence of PTA is high, especially in females and those receiving calcineurine inhibitors (CNI) and mycophenolate mofetil (MMF), and that it was associated with poorer graft outcome but with no effect on patient survival.

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Titel: Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience
verfasst von: Osama Gheith
Ehab Wafa
Nabil Hassan
Amani Mostafa
Hussein A. Sheashaa
Khaled Mahmoud
Ahmed Shokeir
Mohamed A. Ghoneim
Publikationsdatum: 01.08.2009
Verlag: Springer Japan
Erschienen in: Clinical and Experimental Nephrology / Ausgabe 4/2009
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-009-0171-9

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Abstract

Background/Aims

Methods

Results

Conclusion

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