Background
Methods
Study sample
Results
Overall demographics
Nonstatin | Statin | |
---|---|---|
Gender | ||
Male | 841 (54%) | 156 (54%) |
Female | 717 (46%) | 102 (39.5%) |
Education | ||
Primary school | 129 (8.3%) | 19 (7.4%) |
High school diploma | 310 (20.1%) | 54 (21.1%) |
Some college | 263 (17.0%) | 42 (16.4%) |
Bachelor degree | 382 (24.7%) | 70 (27.3%) |
Graduate/professional school | 461 (29.8%) | 71 (27.7%) |
Pathological impact
N
| Mean | Standard error of the mean | p value | |
---|---|---|---|---|
Age at death | ||||
Non statin | 1558 | 81.72 | 0.274 | 0.324 |
Statin | 258 | 81.07 | 0.530 | |
Duration of AD | ||||
Nonstatin | 1520 | 8.8053 | 0.11082 | 0.015 |
Statin | 256 | 8.0938 | 0.27669 | |
Age at onset of AD | ||||
Nonstatin | 1520 | 72.0526 | 0.29309 | 0.846 |
Statin | 256 | 72.1992 | v.57622 | |
Braak stage | ||||
Nonstatin | 1552 | 4.8853 | 0.03685 | 0.292 |
Statin | 258 | 4.7829 | 0.08682 | |
Total amyloid load | ||||
Nonstatin | 1557 | 2.3378 | 0.02420 | 0.635 |
Statin | 258 | 2.3682 | 0.05838 | |
Total tau load | ||||
Nonstatin | 1155 | 1.9957 | 0.01036 | 0.683 |
Statin | 193 | 1.9845 | 0.02595 |
Statin use | APOE4 Mean | p value | Mean difference | Standard error of the difference | 95% confidence interval of the difference | ||||
---|---|---|---|---|---|---|---|---|---|
Lower | Upper | ||||||||
0 | |||||||||
Age at death | 1.00 | 79.64 | |||||||
0.00 | 81.86 | 0.014 | −2.228 | 0.895 | −3.999 | −0.457 | Significant | ||
Education level | 1.00 | 15.59 | 0.879 | −0.132 | 0.868 | −1.835 | 1.570 | Not significant | |
0.00 | 15.72 | ||||||||
Estimated onset age | 1.00 | 69.13 | |||||||
0.00 | 72.25 | 0.002 | −3.118 | 0.992 | −5.083 | −1.153 | Significant | ||
Tauopathy | 1.00 | 2.01 | |||||||
0.00 | 0.34 | 0.000 | 1.672 | 0.076 | 1.523 | 1.820 | Significant | ||
Density of neocortical neuritic plaques (amyloid CERAD score) | 1.00 | 2.60 | |||||||
0.00 | 2.32 | 0.000 | 0.271 | 0.075 | 0.123 | 0.419 | Significant | ||
Braak stage | 1.00 | 5.29 | |||||||
0.00 | 4.87 | 0.000 | 0.420 | 0.112 | 0.199 | 0.642 | Significant | ||
1 | |||||||||
Age at death | 1.00 | 76.81 | 0.036 | −4.543 | 2.159 | −8.795 | −0.291 | Significant | |
0.00 | 81.36 | ||||||||
Education level | 1.00 | 14.13 | 0.444 | −1.598 | 2.085 | −5.704 | 2.508 | Not significant | |
0.00 | 15.72 | ||||||||
Estimated onset age | 1.00 | 67.19 | 0.001 | −5.346 | 1.335 | –8.104 | −2.587 | Significant | |
0.00 | 72.53 | ||||||||
Tauopathy | 1.00 | 2.06 | |||||||
0.00 | 0.37 | 0.000 | 1.691 | 0.183 | 1.330 | 2.051 | Significant | ||
Density of neocortical neuritic plaques (amyloid CERAD score) | 1.00 | 2.56 | 0.393 | 0.207 | 0.242 | −0.270 | 0.684 | Not significant | |
0.00 | 2.36 | ||||||||
Braak stage | 1.00 | 5.25 | 0.167 | 0.498 | 0.359 | −0.210 | 1.206 | Not significant | |
0.00 | 4.75 |
Statin use | APOE4 |
N
| Mean | Standard deviation | Standard error of the mean | |
---|---|---|---|---|---|---|
0 | ||||||
Age at death | 1.00 | 99 | 78.96 | 8.415 | 0.846 | |
0.00 | 1459 | 81.16 | 10.957 | 0.287 | ||
Education level | 1.00 | 99 | 15.59 | 2.966 | 0.298 | |
0.00 | 1459 | 15.72 | 8.601 | 0.225 | ||
Estimated onset age | 1.00 | 99 | 111.61 | 185.605 | 18.654 | |
0.00 | 1459 | 91.61 | 128.096 | 3.354 | ||
Tauopathy | 1.00 | 99 | 2.01 | 0.267 | 0.027 | |
0.00 | 1459 | .34 | 2.698 | 0.071 | ||
Density of neocortical neuritic plaques (amyloid CERAD score) | 1.00 | 99 | 2.60 | 0.699 | 0.070 | |
0.00 | 1459 | 2.32 | 0.983 | 0.026 | ||
Braak stage | 1.00 | 99 | 5.29 | 1.042 | 0.105 | |
0.00 | 1459 | 4.87 | 1.488 | 0.039 | ||
1 | ||||||
Age at death | 1.00 | 16 | 76.19 | 6.036 | 1.509 | |
0.00 | 242 | 80.60 | 8.591 | 0.552 | ||
Education level | 1.00 | 16 | 14.13 | 3.074 | 0.769 | |
0.00 | 242 | 15.72 | 8.290 | 0.533 | ||
Estimated onset age | 1.00 | 16 | 67.19 | 4.764 | 1.191 | |
0.00 | 242 | 80.19 | 84.564 | 5.436 | ||
Tauopathy | 1.00 | 16 | 2.06 | 0.250 | 0.063 | |
0.00 | 242 | 0.37 | 2.673 | 0.172 | ||
Density of neocortical neuritic plaques (amyloid CERAD score) | 1.00 | 16 | 2.56 | 0.727 | 0.182 | |
0.00 | 242 | 2.36 | 0.950 | 0.061 | ||
Braak stage | 1.00 | 16 | 5.25 | 0.856 | 0.214 | |
0.00 | 242 | 4.75 | 1.419 | 0.091 |