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Erschienen in:
19.06.2017 | Maternal-Fetal Medicine
Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation
Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2017
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Purpose
To confirm reduced expression of soluble fms-like tyrosine kinase 1 (sFlt-1) in accreta/increta.
Methods
Formalin-fixed tissue sections from 11 peripartum hysterectomies with invasive placentation and 5 controls were stained for sFlt-1. Stain intensity was scored in selected 100× microscopic fields. We compared sFlt-1 expression in invasive areas among cases, non-invasive areas among cases and areas from control placentas.
Results
Chorionic villi displayed significantly decreased sFlt-1 expression in invasive areas of cases compared to control placentas (p = 0.003), as well as in non-invasive areas of cases compared to control placentas (p = 0.01). There was no difference in sFlt-1 expression between invasive and non-invasive areas among cases.
Conclusions
Expression of sFlt-1 is diminished in villous trophoblasts from patients with placenta increta or percreta. Local depth of invasion was not associated with sFlt-1 expression, suggesting a more global abnormality across the implantation site rather than localized to areas of histologic invasion.