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Rheumatology International

Erschienen in:

01.04.2016 | Short Communication - Observational Research

Drug levels, immunogenicity and assessment of active sacroiliitis in patients with axial spondyloarthritis under biologic tapering strategy

verfasst von: Miriam Almirall, Ramón Gimeno, Tarek Carlos Salman-Monte, Silvia Iniesta, Maria Pilar Lisbona, Joan Maymó

Erschienen in: Rheumatology International | Ausgabe 4/2016

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Abstract

The aim of the study was to assess drug levels, immunogenicity and sacroiliitis on MRI in patients with axial spondyloarthritis under biologic tapering strategy. Consecutive patients with axial spondyloarthritis who remained in low disease activity more than 1 year after dose tapering of infliximab and adalimumab were included. Plasma drug concentrations of TNF inhibitors and anti-drug antibodies were determined, and MRI of sacroiliac joints was evaluated. Of twenty patients included, eighteen had therapeutic drug levels, no patient had anti-drug antibodies, and no patient had active sacroiliitis on MRI. These data could support the biologic tapering strategy and their maintenance over time.

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Titel: Drug levels, immunogenicity and assessment of active sacroiliitis in patients with axial spondyloarthritis under biologic tapering strategy
verfasst von: Miriam Almirall
Ramón Gimeno
Tarek Carlos Salman-Monte
Silvia Iniesta
Maria Pilar Lisbona
Joan Maymó
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 4/2016
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-016-3428-0

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Drug levels, immunogenicity and assessment of active sacroiliitis in patients with axial spondyloarthritis under biologic tapering strategy

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