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Erschienen in: Current Urology Reports 1/2021

01.01.2021 | NEW IMAGING TECHNIQUES (S Rais-Bahrami and K Porter, Section Editors)

Dual-Energy CT for Urinary Stone Evaluation

verfasst von: Alex Nourian, Eric Ghiraldi, Justin I. Friedlander

Erschienen in: Current Urology Reports | Ausgabe 1/2021

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Abstract

Purpose of Review

Conventional CT imaging is an excellent tool for the diagnosis of nephrolithiasis however is limited in its ability to detect stone composition. Dual-energy CT (DECT) scans have demonstrated promise in overcoming this limitation. We review the current utility of DECT in nephrolithiasis.

Recent Findings

DECT is superior to conventional CT in differentiating uric acid stones from non-uric acid stones, with numerous studies reporting sensitivities and specificities approaching > 95%. Dose reduction protocols incorporating low-dose CT scans are commonly used, providing significantly lower effective radiation doses compared to conventional CT. DECT remains an effective diagnostic tool in patients with large body habitus.

Summary

DECT can accurately detect uric acid stones, which can help guide which stones may be suitable to medical dissolution. Further studies evaluating the effectiveness of DECT in guiding management of patients with nephrolithiasis can help to promote its widespread use.
Literatur
6.
Zurück zum Zitat Shahnani PS, Karami M, Astane B, Janghorbani M. The comparative survey of Hounsfield units of stone composition in urolithiasis patients. J Res Med Sci. 2014;19(7):650–3.PubMedPubMedCentral Shahnani PS, Karami M, Astane B, Janghorbani M. The comparative survey of Hounsfield units of stone composition in urolithiasis patients. J Res Med Sci. 2014;19(7):650–3.PubMedPubMedCentral
7.
Zurück zum Zitat Ngo TC, Assimos DG. Uric acid nephrolithiasis: recent progress and future directions. Rev Urol. 2007;9(1):17–27.PubMedPubMedCentral Ngo TC, Assimos DG. Uric acid nephrolithiasis: recent progress and future directions. Rev Urol. 2007;9(1):17–27.PubMedPubMedCentral
9.
Zurück zum Zitat Grajo JR, Patino M, Prochowski A, Sahani DV. Dual energy CT in practice: basic principles and applications. Appl Radiol. 2016;45:6–12. Grajo JR, Patino M, Prochowski A, Sahani DV. Dual energy CT in practice: basic principles and applications. Appl Radiol. 2016;45:6–12.
14.••
Zurück zum Zitat Bonatti M, Lombardo F, Zamboni GA, et al. Renal stones composition in vivo determination: comparison between 100/Sn140 kV dual-energy CT and 120 kV single-energy CT. Urolithiasis. 2017;45(3):255–61. https://doi.org/10.1007/s00240-016-0905-6DECT was directly compared with single energy CT, and the accuracy of stone composition was significantly higher with DECT (90 versus 52%, respectively).CrossRefPubMed Bonatti M, Lombardo F, Zamboni GA, et al. Renal stones composition in vivo determination: comparison between 100/Sn140 kV dual-energy CT and 120 kV single-energy CT. Urolithiasis. 2017;45(3):255–61. https://​doi.​org/​10.​1007/​s00240-016-0905-6DECT was directly compared with single energy CT, and the accuracy of stone composition was significantly higher with DECT (90 versus 52%, respectively).CrossRefPubMed
16.••
Zurück zum Zitat Nestler T, Nestler K, Neisius A, et al. Diagnostic accuracy of third-generation dual-source dual-energy CT: a prospective trial and protocol for clinical implementation. World J Urol. 2019;37(4):735–41. https://doi.org/10.1007/s00345-018-2430-4This study demonstrated that the accuracy of DECT in detecting stone composition can be enhanced by incorporating urinary pH.CrossRefPubMed Nestler T, Nestler K, Neisius A, et al. Diagnostic accuracy of third-generation dual-source dual-energy CT: a prospective trial and protocol for clinical implementation. World J Urol. 2019;37(4):735–41. https://​doi.​org/​10.​1007/​s00345-018-2430-4This study demonstrated that the accuracy of DECT in detecting stone composition can be enhanced by incorporating urinary pH.CrossRefPubMed
18.•
Zurück zum Zitat Apfaltrer G, Dutschke A, Baltzer PAT, et al. Substantial radiation dose reduction with consistent image quality using a novel low-dose stone composition protocol. World J Urol. 2020. https://doi.org/10.1007/s00345-020-03082-6A novel low-dose CT protocol combining a 150 kV spectral filtration unenhanced protocol and a stone-targeted DECT was able to reduce radiation exposure by 25% compared to typical DECT protocols. Apfaltrer G, Dutschke A, Baltzer PAT, et al. Substantial radiation dose reduction with consistent image quality using a novel low-dose stone composition protocol. World J Urol. 2020. https://​doi.​org/​10.​1007/​s00345-020-03082-6A novel low-dose CT protocol combining a 150 kV spectral filtration unenhanced protocol and a stone-targeted DECT was able to reduce radiation exposure by 25% compared to typical DECT protocols.
25.•
Zurück zum Zitat Kordbacheh H, Baliyan V, Uppot RN, Eisner BH, Sahani DV, Kambadakone AR. Dual-source dual-energy ct in detection and characterization of urinary stones in patients with large body habitus: observations in a large cohort. AJR Am J Roentgenol. 2019;212(4):796–801. https://doi.org/10.2214/AJR.18.20293This study demonstrated DECT provided acceptable image quality and was able to characterize stones in patients with large body habitus.CrossRefPubMed Kordbacheh H, Baliyan V, Uppot RN, Eisner BH, Sahani DV, Kambadakone AR. Dual-source dual-energy ct in detection and characterization of urinary stones in patients with large body habitus: observations in a large cohort. AJR Am J Roentgenol. 2019;212(4):796–801. https://​doi.​org/​10.​2214/​AJR.​18.​20293This study demonstrated DECT provided acceptable image quality and was able to characterize stones in patients with large body habitus.CrossRefPubMed
26.•
Zurück zum Zitat Kordbacheh H, Baliyan V, Singh P, Eisner BH, Sahani DV, Kambadakone AR. Rapid kVp switching dual-energy CT in the assessment of urolithiasis in patients with large body habitus: preliminary observations on image quality and stone characterization. Abdom Radiol (NY). 2019;44(3):1019–26. https://doi.org/10.1007/s00261-018-1808-5Although DECT was accurate in detecting stone composition for patients with large body habitus, stone size and patient weight were found to be independent predictors of stone composition with DECT.CrossRef Kordbacheh H, Baliyan V, Singh P, Eisner BH, Sahani DV, Kambadakone AR. Rapid kVp switching dual-energy CT in the assessment of urolithiasis in patients with large body habitus: preliminary observations on image quality and stone characterization. Abdom Radiol (NY). 2019;44(3):1019–26. https://​doi.​org/​10.​1007/​s00261-018-1808-5Although DECT was accurate in detecting stone composition for patients with large body habitus, stone size and patient weight were found to be independent predictors of stone composition with DECT.CrossRef
33.••
Zurück zum Zitat Franken A, Gevenois PA, Muylem AV, Howarth N, Keyzer C. In vivo differentiation of uric acid versus non-uric acid urinary calculi with third-generation dual-source dual-energy ct at reduced radiation dose. AJR Am J Roentgenol. 2018;210(2):358–63. https://doi.org/10.2214/AJR.17.18091This study demonstrated that a limitation of low-dose DECT protocols is that a larger proportion of stones < 5 mm cannot be accurately characterized as UA versus non-UA.CrossRefPubMed Franken A, Gevenois PA, Muylem AV, Howarth N, Keyzer C. In vivo differentiation of uric acid versus non-uric acid urinary calculi with third-generation dual-source dual-energy ct at reduced radiation dose. AJR Am J Roentgenol. 2018;210(2):358–63. https://​doi.​org/​10.​2214/​AJR.​17.​18091This study demonstrated that a limitation of low-dose DECT protocols is that a larger proportion of stones < 5 mm cannot be accurately characterized as UA versus non-UA.CrossRefPubMed
Metadaten
Titel
Dual-Energy CT for Urinary Stone Evaluation
verfasst von
Alex Nourian
Eric Ghiraldi
Justin I. Friedlander
Publikationsdatum
01.01.2021
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 1/2021
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-020-01019-5

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