Erschienen in:
01.12.2011
Dynamics of Inflammatory Markers in Post-Acute Stroke Patients Undergoing Rehabilitation
verfasst von:
Bogdan Nicolae Manolescu, Mihai Berteanu, Luminița Dumitru, Horațiu Dinu, Alina Iliescu, Ileana Cornelia Fărcășanu, Eliza Oprea, Suzana Vlădoiu, Oana Popa, Olga Ianăș
Erschienen in:
Inflammation
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Ausgabe 6/2011
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Abstract
Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ
2 = 4.81, p = 0.028, χ
2 = 10.40, p = 0.005 and χ
2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients’ recovery.