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Journal of the Association for Research in Otolaryngology

18.04.2019 | Research Article

Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 3/2019

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Abstract

The unique composition of the endolymph with a high extracellular K⁺ concentration is essential for sensory transduction in the inner ear. It is secreted by a specialized epithelium, the stria vascularis, that is connected to the fibrocyte meshwork of the spiral ligament in the lateral wall of the cochlea via gap junctions. In this study, we show that in mice the expression of the bicarbonate transporter Slc4a10/Ncbe/Nbcn2 in spiral ligament fibrocytes starts shortly before hearing onset. Its disruption in a C57BL/6 background results in early onset progressive hearing loss. This hearing loss is characterized by a reduced endocochlear potential from hearing onset onward and progressive degeneration of outer hair cells. Notably, the expression of a related bicarbonate transporter, i.e., Slc4a7/Nbcn1, is also lost in spiral ligament fibrocytes of Slc4a10 knockout mice. The histological analysis of the spiral ligament of Slc4a10 knockout mice does not reveal overt fibrocyte loss as reported for Slc4a7 knockout mice. The ultrastructural analysis, however, shows mitochondrial alterations in fibrocytes of Slc4a10 knockout mice. Our data suggest that Slc4a10 and Slc4a7 are functionally related and essential for inner ear homeostasis.

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Titel: Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice
Publikationsdatum: 18.04.2019
Erschienen in: Journal of the Association for Research in Otolaryngology / Ausgabe 3/2019
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-019-00719-1

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Springer Medizin

Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice

Abstract

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Springer Medizin

Abstract

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO