Skip to main content
Erschienen in: The International Journal of Cardiovascular Imaging 12/2018

28.06.2018 | Review Paper

Echocardiographic features of PFOs and paradoxical embolism: a complicated puzzle

verfasst von: Constantina Aggeli, Athanasios Verveniotis, Efstathia Andrikopoulou, Emmanouil Vavuranakis, Konstadinos Toutouzas, Dimitrios Tousoulis

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 12/2018

Einloggen, um Zugang zu erhalten

Abstract

Patent foramen ovale (PFO) is a residual, oblique, slit or tunnel like communication in the atrial septum that persists into adulthood. It is usually an incidental finding with no clinical repercussions. Nevertheless, recent evidence supports the association between the presence of a PFO and a number of clinical conditions, most notably cryptogenic stroke (CS). There is enough evidence that paradoxical embolism is a mechanism which can explain this association. Patient characteristics and certain echocardiography-derived anatomical and hemodynamic features of PFO provide great assistance in estimating the probability of paradoxical embolism. In this review, we initially describe PFO embryology and anatomy. We extensively present the available data on clinical, anatomical and hemodynamic features of PFOs which have been correlated with increased likelihood of paradoxical embolism and recent evidence of therapeutic management.
Literatur
1.
Zurück zum Zitat Hara H, Virmani R, Ladich E et al (2005) Patent foramen ovale: current pathology, pathophysiology, and clinical status. J Am Coll Cardiol 46(9):1768–1776CrossRef Hara H, Virmani R, Ladich E et al (2005) Patent foramen ovale: current pathology, pathophysiology, and clinical status. J Am Coll Cardiol 46(9):1768–1776CrossRef
2.
Zurück zum Zitat Mojadidi M, Christia P, Salamon J et al (2015) Patent foramen ovale: unanswered questions. Eur J Intern Med 26:743–751CrossRef Mojadidi M, Christia P, Salamon J et al (2015) Patent foramen ovale: unanswered questions. Eur J Intern Med 26:743–751CrossRef
3.
Zurück zum Zitat Kutty S, Sengupta PP, Khandheria BK (2012) Patent foramen ovale the known and the to be known. J Am Coll Cardiol 59(19):1665–1671CrossRef Kutty S, Sengupta PP, Khandheria BK (2012) Patent foramen ovale the known and the to be known. J Am Coll Cardiol 59(19):1665–1671CrossRef
4.
Zurück zum Zitat Pizzino F, Khandheria B, Carerj S et al (2016) PFO: button me up, but wait…comprehensive evaluation of the patient. J Cardiol 67(6):485–492CrossRef Pizzino F, Khandheria B, Carerj S et al (2016) PFO: button me up, but wait…comprehensive evaluation of the patient. J Cardiol 67(6):485–492CrossRef
5.
Zurück zum Zitat Hardt SE, Eicken A, Berger F et al (2017) Closure of patent foramen ovale defects using GORE® CARDIOFORM septal occluder: results from a prospective European multicenter study. Catheter Cardiovasc Interv 90(5):824–829CrossRef Hardt SE, Eicken A, Berger F et al (2017) Closure of patent foramen ovale defects using GORE® CARDIOFORM septal occluder: results from a prospective European multicenter study. Catheter Cardiovasc Interv 90(5):824–829CrossRef
6.
Zurück zum Zitat Søndergaar L, Kasner SE, Rhodes JF, for the Gore REDUCE Clinical Study Investigators et al (2017) Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N Engl J Med 377:1033–1042CrossRef Søndergaar L, Kasner SE, Rhodes JF, for the Gore REDUCE Clinical Study Investigators et al (2017) Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N Engl J Med 377:1033–1042CrossRef
7.
Zurück zum Zitat Mas J-L, Derumeaux G, Guillon B for the CLOSE Investigators et al (2017) Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke. N Engl J Med 377:1011–1021CrossRef Mas J-L, Derumeaux G, Guillon B for the CLOSE Investigators et al (2017) Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke. N Engl J Med 377:1011–1021CrossRef
8.
Zurück zum Zitat Saver JL, Carroll JD, Thaler DE for the RESPECT Investigators et al (2017) Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N Engl J Med 377:1022–1032CrossRef Saver JL, Carroll JD, Thaler DE for the RESPECT Investigators et al (2017) Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N Engl J Med 377:1022–1032CrossRef
9.
Zurück zum Zitat Bhatia N, Abushora MY, Donneyong MM et al (2014) Determination of the optimum number of cardiac cycles to differentiate intra-pulmonary shunt and patent foramen ovale by saline contrast two- and three-dimensional echocardiography. Echocardiography 31(3):293–301CrossRef Bhatia N, Abushora MY, Donneyong MM et al (2014) Determination of the optimum number of cardiac cycles to differentiate intra-pulmonary shunt and patent foramen ovale by saline contrast two- and three-dimensional echocardiography. Echocardiography 31(3):293–301CrossRef
10.
Zurück zum Zitat Mahmoud AN, Elgendy IY, Agarwal N et al (2017) Identification and quantification of patent foramen ovale- mediated shunts: echocardiography and transcranial Doppler. Interv Cardiol Clin 6(4):495–504PubMed Mahmoud AN, Elgendy IY, Agarwal N et al (2017) Identification and quantification of patent foramen ovale- mediated shunts: echocardiography and transcranial Doppler. Interv Cardiol Clin 6(4):495–504PubMed
11.
Zurück zum Zitat Silvestry FE, Cohen MS, Armsby LB et al (2015) Guidelines for the echocardiographic assessment of atrial septal defect and patent foramen ovale: from the American Society of Echocardiography and Society for Cardiac Angiography and Interventions.; American Society of Echocardiography; Society for Cardiac Angiography and Interventions. J Am Soc Echocardiogr 28:910–958CrossRef Silvestry FE, Cohen MS, Armsby LB et al (2015) Guidelines for the echocardiographic assessment of atrial septal defect and patent foramen ovale: from the American Society of Echocardiography and Society for Cardiac Angiography and Interventions.; American Society of Echocardiography; Society for Cardiac Angiography and Interventions. J Am Soc Echocardiogr 28:910–958CrossRef
12.
Zurück zum Zitat Carroll JD, Saver JL, Thaler DE RESPECT Investigators et al (2013) Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. N Engl J Med 368(12):1092–1100CrossRef Carroll JD, Saver JL, Thaler DE RESPECT Investigators et al (2013) Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. N Engl J Med 368(12):1092–1100CrossRef
13.
Zurück zum Zitat Olivares-Reyes A, Chan S, Lazar EJ et al (1997) Atrial septal aneurysm: a new classification in two hundred five adults. J Am Soc Echocardiogr 10(6):644–656CrossRef Olivares-Reyes A, Chan S, Lazar EJ et al (1997) Atrial septal aneurysm: a new classification in two hundred five adults. J Am Soc Echocardiogr 10(6):644–656CrossRef
14.
Zurück zum Zitat Kijima Y, Bokhoor P (2015) Patent foramen ovale with right atrial septal pouch. Catheter Cardiovasc Interv 89(5):169–171CrossRef Kijima Y, Bokhoor P (2015) Patent foramen ovale with right atrial septal pouch. Catheter Cardiovasc Interv 89(5):169–171CrossRef
15.
Zurück zum Zitat Lee JY, Song JK, Song JM et al (2010) Association between anatomic features of atrial septal abnormalities obtained by omni-plane transesophageal echocardiography and stroke recurrence in cryptogenic stroke patients with patent foramen ovale. Am J Cardiol 106(1):129–134CrossRef Lee JY, Song JK, Song JM et al (2010) Association between anatomic features of atrial septal abnormalities obtained by omni-plane transesophageal echocardiography and stroke recurrence in cryptogenic stroke patients with patent foramen ovale. Am J Cardiol 106(1):129–134CrossRef
16.
Zurück zum Zitat Goel SS, Tuzcu EM, Shishehbor MH et al (2009) Morphology of the patent foramen ovale in asymptomatic versus symptomatic (stroke or transient ischemic attack) patients. Am J Cardiol 103(1):124–129CrossRef Goel SS, Tuzcu EM, Shishehbor MH et al (2009) Morphology of the patent foramen ovale in asymptomatic versus symptomatic (stroke or transient ischemic attack) patients. Am J Cardiol 103(1):124–129CrossRef
17.
Zurück zum Zitat Fukuoka T, Dembo T, Nagoya H et al (2012) Factors related to recurrence of paradoxical cerebral embolism due to patent foramen ovale. J Neurol 259(6):1051–1055CrossRef Fukuoka T, Dembo T, Nagoya H et al (2012) Factors related to recurrence of paradoxical cerebral embolism due to patent foramen ovale. J Neurol 259(6):1051–1055CrossRef
18.
Zurück zum Zitat Meissner I, Khandheria BK, Heit JA et al (2006) Patent foramen ovale: innocent or guilty? Evidence from a prospective population-based study. J Am Coll Cardiol 47(2):440–445CrossRef Meissner I, Khandheria BK, Heit JA et al (2006) Patent foramen ovale: innocent or guilty? Evidence from a prospective population-based study. J Am Coll Cardiol 47(2):440–445CrossRef
19.
Zurück zum Zitat Rana BS, Shapiro LM, McCarthy KP (2010) Three-dimensional imaging of the atrial septum and patent foramen ovale anatomy: defining the morphological phenotypes of patent foramen ovale. Eur J Echocardiogr 11(10):19–25CrossRef Rana BS, Shapiro LM, McCarthy KP (2010) Three-dimensional imaging of the atrial septum and patent foramen ovale anatomy: defining the morphological phenotypes of patent foramen ovale. Eur J Echocardiogr 11(10):19–25CrossRef
20.
Zurück zum Zitat Vitarelli A, Mangieri E, Capotosto L et al (2014) Echocardiographic findings in simple and complex patent foramen ovale before and after transcatheter closure. Eur Heart J Cardiovasc Imaging 15(12):1377–1385CrossRef Vitarelli A, Mangieri E, Capotosto L et al (2014) Echocardiographic findings in simple and complex patent foramen ovale before and after transcatheter closure. Eur Heart J Cardiovasc Imaging 15(12):1377–1385CrossRef
21.
Zurück zum Zitat Inglessis I, Elmariah S, Rengifo-Moreno PA et al (2013) Long-term experience and outcomes with transcatheter closure of patent foramen ovale. JACC Cardiovasc Interv 6(11):1176–1183CrossRef Inglessis I, Elmariah S, Rengifo-Moreno PA et al (2013) Long-term experience and outcomes with transcatheter closure of patent foramen ovale. JACC Cardiovasc Interv 6(11):1176–1183CrossRef
22.
Zurück zum Zitat Kent DM, Dahabreh IJ, Ruthazer R et al (2016) Device Closure of patent foramen ovale after stroke pooled analysis of completed randomized trials. J Am Coll Cardiol 67(8):907–917CrossRef Kent DM, Dahabreh IJ, Ruthazer R et al (2016) Device Closure of patent foramen ovale after stroke pooled analysis of completed randomized trials. J Am Coll Cardiol 67(8):907–917CrossRef
23.
Zurück zum Zitat Kernan WN, Ovbiagele B, Black HR et al (2014) Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45(7):2160–2236CrossRef Kernan WN, Ovbiagele B, Black HR et al (2014) Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45(7):2160–2236CrossRef
24.
Zurück zum Zitat Kent DM, Ruthazer R, Weimar C et al (2013) An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology 81(7):619–625CrossRef Kent DM, Ruthazer R, Weimar C et al (2013) An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology 81(7):619–625CrossRef
25.
Zurück zum Zitat Katsanos AH, Giannopoulos S, Frogoudaki A et al (2016) The diagnostic yield of transesophageal echocardiography in patients with cryptogenic cerebral ischaemia: a meta-analysis. Eur J Neurol 23(3):569–579CrossRef Katsanos AH, Giannopoulos S, Frogoudaki A et al (2016) The diagnostic yield of transesophageal echocardiography in patients with cryptogenic cerebral ischaemia: a meta-analysis. Eur J Neurol 23(3):569–579CrossRef
26.
Zurück zum Zitat Stortecky S, da Costa BR, Mattle HP et al (2015) Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis. Eur Heart J 36(2):120–128CrossRef Stortecky S, da Costa BR, Mattle HP et al (2015) Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis. Eur Heart J 36(2):120–128CrossRef
27.
Zurück zum Zitat Katsanos AH, Spence JD, Bogiatzi C et al (2014) Recurrent stroke and patent foramen ovale: a systematic review and meta-analysis. Stroke 45(11):3352–3359CrossRef Katsanos AH, Spence JD, Bogiatzi C et al (2014) Recurrent stroke and patent foramen ovale: a systematic review and meta-analysis. Stroke 45(11):3352–3359CrossRef
28.
Zurück zum Zitat Di Tullio M, Sacco R, Sciacca R,et al (2007) Patent foramen ovale and the risk of ischemic stroke in a multiethnic population. J Am Coll Cardiol 49:797–802CrossRef Di Tullio M, Sacco R, Sciacca R,et al (2007) Patent foramen ovale and the risk of ischemic stroke in a multiethnic population. J Am Coll Cardiol 49:797–802CrossRef
29.
Zurück zum Zitat Furlan AJ, Reisman M, Massaro J CLOSURE I Investigators et al (2012) Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med 366(11):991–999CrossRef Furlan AJ, Reisman M, Massaro J CLOSURE I Investigators et al (2012) Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med 366(11):991–999CrossRef
30.
Zurück zum Zitat Meier B, Kalesan B, Mattle HP, PC Trial Investigators et al (2013) Percutaneous closure of patent foramen ovale in cryptogenic embolism. N Engl J Med 368(12):1083–1091CrossRef Meier B, Kalesan B, Mattle HP, PC Trial Investigators et al (2013) Percutaneous closure of patent foramen ovale in cryptogenic embolism. N Engl J Med 368(12):1083–1091CrossRef
33.
Zurück zum Zitat Messé SR, Gronseth G, Kent DM et al (2016) Practice advisory: recurrent stroke with patent foramen ovale (update of practice parameter), Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 87(8):815–821CrossRef Messé SR, Gronseth G, Kent DM et al (2016) Practice advisory: recurrent stroke with patent foramen ovale (update of practice parameter), Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 87(8):815–821CrossRef
34.
Zurück zum Zitat Ropper AH (2017) Tipping point for patent foramen ovale closure. N Engl J Med 377(11):1093–1095CrossRef Ropper AH (2017) Tipping point for patent foramen ovale closure. N Engl J Med 377(11):1093–1095CrossRef
35.
Zurück zum Zitat Farb A, Ibrahim NG, Zuckerman BD (2017) Patent foramen ovale after cryptogenic stroke—assessing the evidence for closure. N Engl J Med 377(11):1006–1100CrossRef Farb A, Ibrahim NG, Zuckerman BD (2017) Patent foramen ovale after cryptogenic stroke—assessing the evidence for closure. N Engl J Med 377(11):1006–1100CrossRef
37.
Zurück zum Zitat European Stroke Organisation(ESO) Executive Committee; ESO Writing Committee (2008) Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 25(5):457–507CrossRef European Stroke Organisation(ESO) Executive Committee; ESO Writing Committee (2008) Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 25(5):457–507CrossRef
38.
Zurück zum Zitat Nietlispach F, Meier B (2016) Percutaneous closure of patent foramen ovale: an underutilized prevention? Eur Heart J 37(26):2023–2028CrossRef Nietlispach F, Meier B (2016) Percutaneous closure of patent foramen ovale: an underutilized prevention? Eur Heart J 37(26):2023–2028CrossRef
39.
Zurück zum Zitat Tobis J, Shenoda M (2012) Percutaneous treatment of patent foramen ovale and atrial septal defects. J Am Coll Cardiol 60(18):1722–1732CrossRef Tobis J, Shenoda M (2012) Percutaneous treatment of patent foramen ovale and atrial septal defects. J Am Coll Cardiol 60(18):1722–1732CrossRef
Metadaten
Titel
Echocardiographic features of PFOs and paradoxical embolism: a complicated puzzle
verfasst von
Constantina Aggeli
Athanasios Verveniotis
Efstathia Andrikopoulou
Emmanouil Vavuranakis
Konstadinos Toutouzas
Dimitrios Tousoulis
Publikationsdatum
28.06.2018
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 12/2018
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-018-1406-1

Weitere Artikel der Ausgabe 12/2018

The International Journal of Cardiovascular Imaging 12/2018 Zur Ausgabe

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.