Introduction
Materials and methods
Study population
Intervention group | Control group | |
---|---|---|
Randomized study population, N | 54 | 42 |
Excluded/withdrawn, n | 1a | 3b |
Analysed population | 53 | 39 |
Died during the study period, n | 2 | 2 |
Time remaining in the study, mean ± SD | 360 ± 25 | 356 ± 43 |
Age at inclusion, mean ± SD | 60.6 ± 7.9 | 60.7 ± 10.0 |
Men, n (%) | 37 (70) | 28 (72) |
Cohabitant with partner, % | 41 (77) | 32 (82) |
In active work, % | 38 (72) | 25 (66) |
HPV positivec, n (%) | 36 (84) | 24 (71) |
Health-related quality of life at baseline, median (1st quartile-3rd quartile)d | 0.76 (0.73–1.0) 0.88 (0.87–0.97) | 0.74 (0.53–0.85) 0.88 (0.75–0.91) |
Person-centred care intervention and standard medical care
Costs
Healthcare resource use and direct costs
Lost production and productivity costs
Health-related quality of life
Analyses
Results
Cost component | Intervention group | Control group | Cost |
---|---|---|---|
Quantity | Quantity | Mean (95% CI), SEK | |
Specialized outpatient healthcare | |||
Physician contact | 567 | 441 | 2199 (1200; 2399) |
Incl. radiation therapy | 155 | 121 | 6210 (6014; 6406) |
Nurse contact | 2138 | 1661 | 324 (285; 364) |
Incl. radiation therapy | 1058 | 792 | 6550 (6430; 6670) |
Speech therapy contact | 24 | 38 | 3873 (2025; 5721) |
Dietitian contact | 146 | 125 | 627 (511; 743) |
Psychiatric contact | 29 | 30 | 1350 (883; 1818) |
Other outpatient contact | 60 | 96 | 137 (38; 237) |
No. of outpatient contacts | 2964 | 2391 | |
Intervention contacts | |||
Interview (1 h each) | 53 | 0 | |
Phone call/visit (15 min each) | 603 | 0 | |
Estimated in hours | 204 | 0 | 265 /hour |
Inpatient healthcare | |||
Registered hospitalizations, n/days | 80 / 771 | 63 / 577 | |
Additional hospitalizations, days | 203 | 256 | 6813 /day |
Hospital costs incl. acute care | 79 | 63 | 68,703 (57,180; 80,227) |
Incl. radiation therapy | 7 | 3 | 19,146 (4212; 34,079) |
X-ray examination | 33 | 25 | 4749 (2412; 7086) |
Other laboratory tests | 74 | 59 | 1702 (1304; 2101) |
Surgery (incl. intensive care and post-operative costs) | 33 | 28 | 18,664 (6957; 30,370) |
Drugs and other materials | 28 | 21 | 2911 (1470; 4351) |
Cost component | Intervention group | Control group | Differencea |
---|---|---|---|
Mean cost (95% CI), SEK | Mean cost (95% CI), SEK | Mean cost (95% CI), SEK | |
Specialized outpatient healthcare | |||
Physician contact | 23,463 (18,283; 28,644) | 24,997 (18,966; 31,028) | − 1534 (− 9562; 6494) |
Incl. radiation therapy | 17,743 (14,471; 21,015) | 18,721 (15,306; 22,135) | − 978 (− 5812; 3856) |
Nurse contact | 13,510 (10,236; 16,784) | 13,238 (7877; 18,599) | 272 (− 5851; 6395) |
Incl. radiation therapy | 129,867 (114,569; 145,164) | 132,202 (115,040; 149,364) | − 2335 (− 25,356; 20,686) |
Speech therapy contact | 2050 (450; 3649) | 3372 (861; 5883) | − 1322 (− 4221; 1577) |
Dietitian contact | 1996 (1407; 2585) | 1645 (1119; 2172) | 350 (− 464; 1165) |
Psychiatric contact | 767 (− 201; 1736) | 1000 (166; 1834) | − 233 (− 1496; 1030) |
Other outpatient contact | 228 (− 22; 479) | 239 (18; 461) | − 11 (− 319; 297) |
Intervention contacts | 1019 (906; 1132) | 1019 (906; 1132) | |
Inpatient healthcare | |||
Hospitalizations (not registered) | 27,381 (11,961; 42,800) | 44,721 (19,301; 70,141) | − 17,341 (− 46,174; 11,493) |
Hospital costs incl. acute care | 102,411 (71,061; 133,760) | 110,978 (74,331; 147,625) | − 8567 (− 61,567; 44,432) |
Incl. radiation therapy | 1198 (152; 2244) | 3281 (− 1111; 7673) | − 2083 (− 6548; 2382) |
X-ray examination | 3337 (391; 6282) | 2528 (648; 4408) | 809 (− 2831; 4448) |
Other laboratory tests | 2348 (1339; 3358) | 2164 (1370; 3860) | − 267 (− 2008; 1475) |
Surgery (incl. intensive care and post-operative costs) | 9212 (3080; 15,344) | 16,673 (− 1001; 34,347) | − 7461 (− 26,867; 11,944) |
Drugs and other materials | 1099 (262; 1936) | 2164 (187; 4140) | − 1065 (− 3288; 1158) |
Cost component | Intervention group | Control group |
---|---|---|
Mean cost (95% CI), SEK | Mean cost (95% CI), SEK | |
Total cost | ||
Outpatient care | 190,643 (169,082; 212,204) | 195,415 (170,899; 219,930) |
Inpatient care | 146,984 (105,979; 187,990) | 182,959 (124,511; 241,408) |
Productivity costs | 167,645 (126,724; 208,565) | 144,172 (95,408; 192,936) |
Men | n = 37 | n = 28 |
Outpatient care | 186,805 (162,208; 211,402) | 196,959 (165,891; 228,027) |
Inpatient care | 130,367 (91,121; 169,612) | 168,428 (101,003; 235,853) |
Productivity costs | 179,422 (137,178; 221,667) | 114,171 (62,225; 166,118) |
Women | n = 16 | n = 11 |
Outpatient care | 199,518 (157,078; 241,958) | 191,484 (156,698; 226,269) |
Inpatient care | 185,413 (90,719; 280,107) | 219,949 (93,151; 346,747) |
Productivity costs | 140,409 (60,257; 220,561) | 220,539 (117,736; 323,341) |
HPV negative | n = 7 | n = 10 |
Outpatient care | 244,246 (196,891; 291,601) | 183,677 (123,156; 244,197) |
Inpatient care | 145,513 (46,553; 244,473) | 217,746 (59,124; 376,367) |
Productivity costs | 128,115 (− 23,609; 279,839) | 50,125 (− 24,135; 124,386) |
HPV positive | n = 36 | n = 24 |
Outpatient care | 180,215 (153,844; 206,587) | 199,735 (170,563; 228,907) |
Inpatient care | 158,004 (104,281; 211,728) | 147,988 (89,912; 206,065) |
Productivity costs | 190,919 (146,501; 235,337) | 176,270 (118,775; 233,766) |
Age ≤ 54 years | n = 13 | n = 10 |
Outpatient care | 195,123 (168,379; 221,867) | 201,758 (167,110; 236,406) |
Inpatient care | 140,377 (92,665; 188,088) | 198,002 (56,710; 339,295) |
Productivity costs | 237,914 (174,593; 301,236) | 227,716 (120,789; 334,644) |
Age 55–64 years | n = 29 | n = 15 |
Outpatient care | 195,692 (160,716; 230,669) | 195,211 (154,417; 236,005) |
Inpatient care | 131,946 (66,146; 197,745) | 219,897 (121,554; 318,240) |
Productivity costs | 187,759 (1353; 240,167) | 196,987 (133,302; 260,673) |
Age ≥ 65 years | n = 11 | n = 14 |
Outpatient care | 172,038 (142,430; 201,643) | 191,101 (144,399; 237,804) |
Inpatient care | 194,441 (116,432; 272,450) | 132,638 (62,009; 203,267) |
Productivity costs | 31,569 (− 14,295; 77,433) | 27,910 (− 25,575; 81,396) |
Average cost | 505,272 (440,960; 569,584) | 522,546 (442,167; 602,926) |