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17.08.2018 | Original Article

Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit

verfasst von: Florent Puisset, Laurence Bigay-Game, Marie Noëlle Paludetto, Audrey Martel, Sophie Perriat, Audrey Rabeau, Jean Marie Canonge, Julien Mazieres

Erschienen in: Supportive Care in Cancer | Ausgabe 5/2019

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Abstract

Purpose

Hydration is needed before and after cisplatin infusion for reducing the risk of nephrotoxicity. Even though there is no standard regimen, patients receive mostly intravenous hydration before and after cisplatin leading hospitalization during at least one night. Since the feasibility has been published, oral hydration after cisplatin was implemented in our practice. The safety of this new way of hydration needs to be assessed in clinical practice.

Methods

We collected medical records from patients treated by cisplatin for lung cancer in our unit between 2010 and 2016. We retrospectively analyzed the incidence of cisplatin induced nephrotoxicity between after and before the change of hydration regimen.

Results

Our patient cohort included 241 patients hydrated by intravenous regimen (IV/IV group) and 276 patient hydrated by intravenous and oral regimen (IV/PO group). Grade ≥ 1 nephrotoxicity occurred in 39.4 and 25.7% in the IV/IV and IV/PO groups respectively (p = 0.001). Age over 70 at baseline was a predictive factor for nephrotoxicity, but not estimated glomerular filtration rate nor cisplatin-associated drugs. After a multivariate analysis, age remained a predictive factor for nephrotoxicity and IV/PO hydration associated with a decrease in nephrotoxic risk.

Conclusion

The implementation of oral hydration in our practice was not associated with an increase in nephrotoxicity. Our observation based on large data from clinical practice shows that oral hydration after cisplatin is safe.

Masters GA, Temin S, Azzoli CG, Giaccone G, Baker S Jr, Brahmer JR, Ellis PM, Gajra A, Rackear N, Schiller JH, Smith TJ, Strawn JR, Trent D, Johnson DH, American Society of Clinical Oncology Clinical Practice (2015) Systemic therapy for stage IV non–small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 33(30):3488–3515. https://doi.org/10.1200/JCO.2015.62.1342 CrossRefPubMedPubMedCentral

Facchetti G, Petrella F, Spaggiari L, Rimoldi I (2017) Malignant pleural mesothelioma: state of the art and advanced cell therapy. Eur J Med Chem 142:266–270. https://doi.org/10.1016/j.ejmech.2017.07.063 CrossRefPubMed

Kalemkerian GP (2014) Advances in pharmacotherapy of small cell lung cancer. Expert Opin Pharmacother 15(16):2385–2396. https://doi.org/10.1517/14656566.2014.957180 CrossRefPubMed

Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of cisplatin nephrotoxicity. Toxins 2(11):2490–2518. https://doi.org/10.3390/toxins2112490 CrossRefPubMedPubMedCentral

Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73(9):994–1007. https://doi.org/10.1038/sj.ki.5002786 CrossRefPubMed

Oh G-S, Kim H-J, Shen A, Lee SB, Khadka D, Pandit A, So HS (2014) Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press E BP 12(2):55–65. https://doi.org/10.5049/EBP.2014.12.2.55 CrossRefPubMed

Launay-Vacher V, Rey J-B, Isnard-Bagnis C, Deray G, Daouphars M (2008) European Society of Clinical Pharmacy Special Interest Group on Cancer Care. Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care. Cancer Chemother Pharmacol 61(6):903–909. https://doi.org/10.1007/s00280-008-0711-0 CrossRefPubMed

Fukushima K, Okada A, Oe H, Hirasaki M, Hamori M, Nishimura A, Shibata N, Sugioka N (2018 Apr) Pharmacokinetic-pharmacodynamic analysis of cisplatin with hydration and mannitol diuresis: the contribution of urine cisplatin concentration to nephrotoxicity. Eur J Drug Metab Pharmacokinet 43(2):193–203. https://doi.org/10.1007/s13318-017-0436-8 CrossRefPubMed

Stewart DJ, Dulberg CS, Mikhael NZ, Redmond MD, Montpetit VA, Goel R (1997) Association of cisplatin nephrotoxicity with patient characteristics and cisplatin administration methods. Cancer Chemother Pharmacol 40(4):293–308. https://doi.org/10.1007/s002800050661 CrossRefPubMed

10.

Lavolé A, Danel S, Baudrin L et al (2012) Routine administration of a single dose of cisplatin ≥75mg/m² after short hydration in an outpatient lung-cancer clinic. Bull Cancer (Paris) (4):43–48. https://doi.org/10.1684/bdc.2012.1555

11.

Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med 130(6):461–470CrossRefPubMed

12.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute dialysis quality initiative workgroup. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care Lond Engl 8(4):R204–R212. https://doi.org/10.1186/cc2872 CrossRef

13.

Willox JC, McAllister EJ, Sangster G, Kaye SB (1986) Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial. Br J Cancer 54(1):19–23CrossRefPubMedPubMedCentral

14.

Bodnar L, Wcislo G, Gasowska-Bodnar A, Synowiec A, Szarlej-Wcisło K, Szczylik C (2008) Renal protection with magnesium subcarbonate and magnesium sulphate in patients with epithelial ovarian cancer after cisplatin and paclitaxel chemotherapy: a randomised phase II study. Eur J Cancer Oxf Engl 1990 44(17):2608–2614. https://doi.org/10.1016/j.ejca.2008.08.005 CrossRef

15.

Furukawa N, Kawaguchi R, Kobayashi H (2012) Use of high-dose cisplatin with aprepitant in an outpatient setting. Eur J Cancer Care (Engl) 21(4):436–441. https://doi.org/10.1111/j.1365-2354.2011.01284.x CrossRef

16.

Reece PA, Stafford I, Russell J, Khan M, Gill PG (1987) Creatinine clearance as a predictor of ultrafilterable platinum disposition in cancer patients treated with cisplatin: relationship between peak ultrafilterable platinum plasma levels and nephrotoxicity. J Clin Oncol 5(2):304–309. https://doi.org/10.1200/JCO.1987.5.2.304 CrossRefPubMed

17.

Sassier M, Dugué AE, Clarisse B, Lesueur P, Avrillon V, Bizieux-Thaminy A, Auliac JB, Kaluzinski L, Tillon J, Robinet G, le Caer H, Monnet I, Madroszyk A, Boza G, Falchero L, Fournel P, Egenod T, Toffart AC, Leiber N, Do P, Gervais R (2015) Renal insufficiency is the leading cause of double maintenance (bevacizumab and pemetrexed) discontinuation for toxicity to advanced non-small cell lung cancer in real world setting. Lung Cancer 89(2):161–166. https://doi.org/10.1016/j.lungcan.2015.05.005 CrossRefPubMed

18.

Madias NE, Harrington JT (1978) Platinum nephrotoxicity. Am J Med 65(2):307–314CrossRefPubMed

19.

Sato K, Watanabe S, Ohtsubo A et al (2016) Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. BMC Cancer 16(1). https://doi.org/10.1186/s12885-016-2271-8

20.

Tiseo M, Martelli O, Mancuso A, Sormani MP, Bruzzi P, di Salvia R, de Marinis F, Ardizzoni A (2007) Short hydration regimen and nephrotoxicity of intermediate to high-dose cisplatin-based chemotherapy for outpatient treatment in lung cancer and mesothelioma. Tumori 93(2):138–144CrossRefPubMed

21.

Ouchi A, Asano M, Aono K, Watanabe T, Kato T (2014) Comparison of short and continuous hydration regimen in chemotherapy containing intermediate- to high-dose cisplatin. J Oncol 2014:1–4. https://doi.org/10.1155/2014/767652 CrossRef

22.

Yamaguchi T, Uozu S, Isogai S, Hayashi M, Goto Y, Nakanishi T, Imaizumi K (2017) Short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity in lung cancer: a retrospective analysis. Support Care Cancer 25(4):1215–1220. https://doi.org/10.1007/s00520-016-3512-8 CrossRefPubMed

23.

Hotta K, Takigawa N, Hisamoto-Sato A, Ichihara E, Kudo K, Uchida K, Yanase-Nakamura K, Tanaka H, Kato Y, Tabata M, Tanimoto M, Kiura K (2013) Reappraisal of short-term low-volume hydration in cisplatin-based chemotherapy: results of a prospective feasibility study in advanced lung Cancer in the Okayama Lung Cancer Study Group Trial 1002. Jpn J Clin Oncol 43(11):1115–1123. https://doi.org/10.1093/jjco/hyt128 CrossRefPubMed

24.

Ninomiya K, Hotta K, Hisamoto-Sato A, Ichihara E, Gotoda H, Morichika D, Tamura T, Kayatani H, Minami D, Kubo T, Tabata M, Tanimoto M, Kiura K (2016) Short-term low-volume hydration in cisplatin-based chemotherapy for patients with lung cancer: the second prospective feasibility study in the Okayama Lung Cancer Study Group Trial 1201. Int J Clin Oncol 21(1):81–87. https://doi.org/10.1007/s10147-015-0860-1 CrossRefPubMed

25.

Horinouchi H, Kubota K, Itani H, Taniyama TK, Nakamichi S, Wakui H, Kanda S, Nokihara H, Yamamoto N, Sekine I, Tamura T (2013) Short hydration in chemotherapy containing cisplatin (>=75 mg/m²) for patients with lung cancer: a prospective study. Jpn J Clin Oncol 43(11):1105–1109. https://doi.org/10.1093/jjco/hyt122 CrossRefPubMed

26.

Sato J, Morikawa N, Nitanai H et al (2016) Feasibility study of short hydration using oral rehydration solution in cisplatin including chemotherapy of lung cancer. J Pharm Health Care Sci 2(1). https://doi.org/10.1186/s40780-016-0041-z

27.

Mor V, Stalker MZ, Gralla R, Scher HI, Cimma C, Park D, Flaherty AM, Kiss M, Nelson P, Laliberte L, Schwartz R, Marks PA, Oettgen HF (1988) Day hospital as an alternative to inpatient care for cancer patients: a random assignment trial. J Clin Epidemiol 41(8):771–785CrossRefPubMed

28.

Azzoli CG, Baker S, Temin S et al (2009) American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol Off J Am Soc Clin Oncol 27(36):6251–6266. https://doi.org/10.1200/JCO.2009.23.5622 CrossRef

29.

Azuma T, Matayoshi Y, Sato Y, Sato Y, Nagase Y, Oshi M (2016) The safety and effect of chemotherapy with short hydration for urothelial cancer on patients’ quality of life. Jpn J Clin Oncol 46(10):958–963. https://doi.org/10.1093/jjco/hyw097 CrossRefPubMed

Titel: Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit
verfasst von: Florent Puisset
Laurence Bigay-Game
Marie Noëlle Paludetto
Audrey Martel
Sophie Perriat
Audrey Rabeau
Jean Marie Canonge
Julien Mazieres
Publikationsdatum: 17.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 5/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4415-7

Springer Medizin

Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit