Editors’ Introduction to the NAFLD and NASH Special Issue

Excerpt

We are pleased to introduce the second annual special supplement to Digestive Diseases and Sciences dedicated to Emmet B. Keeffe, which this year focuses on nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Coverage of these topics is all the more timely due to the rising prevalence of these liver diseases, with NAFLD now the most common chronic liver disease with its associated substantial disease burden. Not only does NAFLD increase the overall mortality, NASH cirrhosis is predicted to be the number one indication for liver transplantation in the USA within the next 4–5 years. Furthermore, NASH cirrhosis has substantially contributed to the etiology of the rapidly increasing number of liver cancers worldwide. Although the pathogenesis of NASH is becoming better understood with new treatment options on the horizon, many obstacles still remain in regard to its understanding, to making a correct diagnosis, and to providing effective therapy. We would like to briefly summarize and highlight the articles included in this issue in the order in which they appear. …