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Journal of Diabetes & Metabolic Disorders
Erschienen in: Journal of Diabetes & Metabolic Disorders 1/2021

22.01.2021 | Research article

Effect of Alpinia officinarum extract on reproductive damages in streptozotocin induced diabetic male rats

verfasst von: Hamid Heidari, Maasoume Abdollahi, Sima Khani, Fatemeh Nojavan, Samira Khani

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2021

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Abstract

Purpose

Infertility is one of the systemic problems in diabetic men. The purpose of the present study is investigation of the effects of the Alpinia officinarum (AO) hydro-alcoholic extract on the reproductive system damages in diabetic male rats.

Methods

Twenty four male rats were randomly assigned into 4 groups (n = 6); i.e., control, diabetic control, and diabetic rats treated orally with AO extract (200 and 500 mg kg−1). A single dose (60 mg kg-1) of streptozotocin (STZ) was injected intraperitoneally (IP) to induce diabetes. After 8 weeks of treatment, blood samples, testis, and cauda epididymis were excised to evaluate specific hormonal changes, sperm parameters, and testis morphology.

Results

Diabetic control rats showed remarkably lower body and testicular weights, testicular volumes, and sperm parameters compared with the control group (p <0.05). Diabetic control rats also exhibited significantly decreased serum testosterone and follicle stimulating hormone (FSH). Sperm parameters were considerably enhanced in diabetic animals gavaged with AO extract. Testosterone levels were significantly elevated by administrating 500 mg kg−1 AO extract to the diabetic control rats (p <0.05). The morphological assessment of testis of treatment group (500 mg kg−1) indicated remarkable differences (p <0.05) by increasing the seminiferous tubules diameter (STD) and thickness of the seminiferous epithelium (TSE) compared with diabetic control rats.

Conclusion

As demonstrated by the results, AO extract ameliorated sperm damage and improved sperm morphology besides improving histological damage in the testis in diabetic rats. In addition, the dose of 500 mg kg−1 worked more efficiently than 200 mg kg−1.
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Metadaten
Titel
Effect of Alpinia officinarum extract on reproductive damages in streptozotocin induced diabetic male rats
verfasst von
Hamid Heidari
Maasoume Abdollahi
Sima Khani
Fatemeh Nojavan
Samira Khani
Publikationsdatum
22.01.2021
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2021
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-020-00711-0

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