Background
Methods
Study population
Assessment of corneal endothelial cells
Surgical procedures of corneal cross-linking
Statistical analysis
Results
Demographic | Mean ± standard deviation (range) |
---|---|
Age (years) | 26.2 ± 8.6 (20 to 47) |
Gender (% female) | 61 |
Spherical equivalent refraction (D) | −4.52 ± 4.28 (1.00 to −13.50) |
Manifest cylinder (D) | − 4.19 ± 3.79 (0.00 to − 11.00) |
UDVA (logMAR) | 0.25 ± 0.27 (0.7 to − 0.08) |
Mean keratometric readings (D) | 49.8 ± 3.2 (44.2 to 55.3) |
Central cornea thickness (μm) | 478.1 ± 51.1 (400 to 581) |
Stage of keratoconus (eyes) | |
Stage I | 8 |
Stage II | 18 |
Stage III | 5 |
Location | ECD (cells/mm2) | CV (%) | HEX (%) | ||||||
---|---|---|---|---|---|---|---|---|---|
Preoperative | Postoperative (6 months) | P value | Preoperative | Postoperative (6 months) | P value | Preoperative | Postoperative (6 months) | P value | |
Superior | 2843 ± 271 | 2803 ± 293 | 0.16 | 41.3 ± 5.7 | 42.5 ± 6.5 | 0.23 | 34.9 ± 10.7 | 33.8 ± 9.9 | 0.14 |
Nasal Superior | 2815 ± 297 | 2772 ± 273 | 0.12 | 41.2 ± 5.4 | 42.4 ± 6.8 | 0.21 | 35.7 ± 8.2 | 35.7 ± 9.0 | 0.80 |
Temporal Superior | 2749 ± 264 | 2716 ± 245 | 0.17 | 42.1 ± 6.3 | 43.2 ± 6.7 | 0.11 | 33.4 ± 10.7 | 33.0 ± 10.8 | 0.30 |
Inferior | 2759 ± 281 | 2734 ± 227 | 0.28 | 41.6 ± 6.5 | 42.5 ± 6.9 | 0.21 | 32.5 ± 8.5 | 33.0 ± 9.6 | 0.38 |
Nasal Inferior | 2703 ± 452 | 2655 ± 645 | 0.37 | 41.6 ± 5.0 | 42.8 ± 7.6 | 0.15 | 31.4 ± 8.9 | 31.2 ± 10.1 | 0.49 |
Temporal Inferior | 2645 ± 390 | 2603 ± 491 | 0.17 | 42.0 ± 7.3 | 42.9 ± 7.4 | 0.19 | 32.0 ± 8.7 | 31.9 ± 10.1 | 0.64 |
Endothelial cell density
Coefficient of variation
Percentage of hexagonal cells
Discussion
Author | Year | Eyes | Follow-up | Surgical Method | ECD loss (%) | CV, HEX (%) | Location | Device |
---|---|---|---|---|---|---|---|---|
Vinciguerra P et al. [11] | 2009 | 28 | 2Y | Standard | 4.9 | N.A. | Center | Unknown (Konan) |
Caporossi A et al. [12] | 2010 | 44 | 4Y | Standard | 0.7 | N.A. | Noncon ROBO V (Konan) | |
Spada L et al. [13] | 2012 | 16 | 1Y | Trans-epithelial | 0.5 | CV 28 to 29 | SP-500 (SEED) | |
Kymionis GD et al. [10] | 2014 | 25 | 5Y | Standard | 3.6 | N.A. | EM-3000 (TOMEY) | |
Wittig-silva C et al. [14] | 2014 | 46 | 3Y | Standard | 2.5 | N.A. | SP-2000 (Topcon) | |
Cingü AK et al. [15] | 2014 | 36 | 6 M | Accelerated | 0.7 | CV 44 to 46 | Noncon ROBO SP-6000 (Konan) | |
HEX 45 to 44 | ||||||||
Goldich Y et al. [16] | 2014 | 17 | 3Y | Standard | 7.5 | N.A. | Noncon ROBO SP-6000 (Konan) | |
Nasrollahi K et al. [17] | 2015 | 140 | 1Y | Standard | 1.5 | CV 39 to 40 | Unknown (TOMEY) | |
HEX 54 to 53 | ||||||||
Sedaghat M et al. [18] | 2015 | 97 | 1Y | Standard | 3.3 | CV 18 to 20 | SP-2000 (Topcon) | |
Sadoughi MM et al. [19] | 2016 | 15 | 1Y | Standard | 1.5 | CV 34 to 35 | SP-2000 (Topcon) | |
HEX 56 to 57 | ||||||||
Giacomin NT et al. [20] | 2016 | 40 | 4Y | Standard | −0.1 | N.A. | Unknown (Konan) | |
Badawi AE et al. [21] | 2016 | 40 | 1Y | Accelerated | 0.9 | CV 35 to 36 | EM-3000 (TOMEY) | |
HEX 55 to 56 | ||||||||
Current | 31 | 6 M | Standard | 1.2* | CV 41 to 42* | Periphery | EM-3000 (TOMEY) | |
HEX 33 to 33* |