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01.08.2012 | Gynecologic Oncology

Effect of platinum-containing chemotherapy on olfactory, gustatory, and hearing function in ovarian cancer patients

verfasst von: Silke Steinbach, Walter Hundt, Barbara Schmalfeldt, Christina Böhner, Sabina Berktold, Petra Wolf, Nadia Harbeck

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2012

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Abstract

Purpose

Most patients with epithelial ovarian cancer have a poor overall prognosis. Therefore, one of the main therapeutic aims after cytoreductive surgery for these patients is to identify, delay and relieve chemotherapy-induced side effects and optimise the quality of life, especially after first-line therapy.

Methods

Twelve ovarian cancer patients undergoing carboplatinum-containing chemotherapy were assessed using validated tests for olfactory, gustatory, and hearing functions before, during, immediately after, and 3 months after chemotherapy.

Results

All chemosensory functions decreased during and after carboplatinum-containing chemotherapy, but recovered 3 months after treatment ended. For olfaction, this decrease was significant, affecting odour identification minimally, and odour threshold the most. For taste, the decrease was not significant, but could be observed in total scores and in each quality (sweet, sour, salty, and bitter). For hearing, the decrease was not significant, but a recovery of the deep and middle frequencies was clearly evident 3 months after chemotherapy.

Conclusions

Patients must be informed about transient declines in chemosensory functions during chemotherapy. Symptomatic relief provided by the use of more spices, a small amount of glutamate, or additional flavouring might help to compensate for decreased functions during chemotherapy and increase patient quality of life.

Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) Cancer statistics. CA Cancer J Clin 55:10–30PubMedCrossRef

Markman M (2008) Pharmaceutical management of ovarian cancer: current status. Drugs 68:771–789PubMedCrossRef

Högberg T, Glimelius B, Nygren P, SBU-group (2001) Swedish council of technology assessment in health care. A systematic overview of chemotherapy effects in ovarian cancer. Acta Oncol 40:340–360PubMedCrossRef

Buckingham R, Fitt J, Sitzia J (1997) Patients experiences of chemotherapy: side-effects of carboplatin in the treatment of carcinoma of the ovary. Eur J Cancer Care 6:59–71CrossRef

Duffy VB, Backstrand JR, Ferris AM (1995) Olfactory dysfunction and related nutritional risk in free-living, elderly women. J Am Diet Assoc 95:879–884PubMedCrossRef

Ovesen L, Sorensen M, Hannibal J, Allingstrup L (1991) Electrical taste detection thresholds and chemical smell detection thresholds in patients with cancer. Cancer 68:2260–2265PubMedCrossRef

Yakirevitch A, Talmi YP, Baram Y, Weitzen R, Pfeffer MR (2005) Effects of cisplatin on olfactory function in cancer patients. Br J Cancer 92:1611–1613PubMedCrossRef

Steinbach S, Hummel T, Böhner C, Berktold S, Hundt W, Kriner M, Heinrich P, Sommer H, Hanusch C, Prechtl A, Schmidt B, Bauerfeind I, Seck K, Jacobs VR, Schmalfeldt B, Harbeck N (2009) Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynaecologic malignancies. JCO 27:1899–1905CrossRef

Minakata Y, Yamagata T, Nakanishi H, Nishimoto T, Nakanishi M, Mune M, Yukawa S (2002) Severe gustatory disorder caused by cisplatin and etoposide. Int J Clin Oncol 7:124–127PubMed

10.

Yamagata T, Nakamura Y, Yamagata Y, Nakanishi M, Matsunaga K, Nakanishi H, Nishimoto T, Minakata Y, Mune M, Yukawa S (2003) The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer. J Exp Clin Cancer Res 22:557–563PubMed

11.

Berteretche MV, Dalix AM, dOrnano AM, Bellisle F, Khayat D, Faurion A (2004) Descreased taste sensitivity in cancer patients under chemotherapy. Support Care Cancer 12:571–576PubMedCrossRef

12.

Wake M, Takeno S, Ibrahim D, Harrison R, Mount R (1993) Carboplatin ototoxicity: an animal model. J Laryngol Otol 107:585–589PubMed

13.

Van Warmerdam LJ, Rodenhuis S, van der Wall E, Maes RA, Beijnen JH (1996) Pharmacokinetics and pharmacodynamics of carboplatin administered in a high-dose combination regimen with thiotepa, cyclophosphamide and peripheral stem cell support. Br J Cancer 73:979–984PubMedCrossRef

14.

Hummel T, MackaySim A, Gudziol H, Kobal G (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch ORL 264:237–243CrossRef

15.

Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, Kobal G (2003) Quantitative assessment of gustatory function in a clinical context using impregnated “taste strips”. Rhinology 41:2–6PubMed

16.

Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S (1996) “Sniffin’ sticks”: screening of olfactory performance. Rhinology 34:222–226PubMed

17.

Jones-Gotman M, Zatorre RJ (1988) Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 26:387–400PubMedCrossRef

18.

Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL (1999) Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21:325–340PubMedCrossRef

19.

Steinbach S, Hundt W, Zahnert T, Berktold S, Böhner C, Gottschalk N, Hamann M, Kriner M, Heinrich P, Schmalfeldt B, Harbeck N (2010) Gustatory and olfactory function in breast cancer patients. Support Care Cancer 18:707–713PubMedCrossRef

20.

Murphy C, Cain WS, Bartoshuk LM (1977) Mutual action of taste and olfaction. Sens Process 1:204–211

21.

Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. J Pain Symptom Manage 34:403–412PubMedCrossRef

22.

Beites CL, Kawauchi S, Crocker CE, Calof AL (2005) Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res 306:309–316PubMedCrossRef

23.

Duffy V, Lucchina L, Fast K et al (1998) Taste and cancer. In: Berger A (ed) Principles and practice of supportive oncology. Lippincott-Raven, Philadelphia, pp 141–151

24.

Kaufman Arenberg I (1993) Dizziness and balance disorder: an interdisciplinary approval. Kugler, New York

25.

Bokemeyer C, Berger CC, Hartmann JT, Kollmannsberger C, Schmoll HJ, Kuczyk MA, Kanz L (1998) Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br J Cancer 77:1355–1362PubMedCrossRef

26.

Rademaker-Lakhai JM, Crul M, Zuur L, Baas P, Beijnen JH, Simis YJ, van Zandwijk N, Schellens JH (2006) Relationship between cisplatin administration and the development of ototoxicity. J Clin Oncol 24:918–924PubMedCrossRef

27.

Prescott J (2004) Effects of added glutamate on liking for novel food flavors. Appetite 42:143–150PubMedCrossRef

28.

Schiffmann SS, Sattely-Miller EA, Taylor EL, Graham BG, Landerman LR, Zervakis J, Campagna LK, Cohen HJ, Blackwell S, Garst JL (2007) Combination of flavor enhancement and chemosensory education improves nutritional status in older cancer patients. J Nutr Health Aging 11:439–454

29.

Yeomans MR, Gould NJ, Mobini S, Prescott J (2008) Acquired flavor acceptance and intake facilitated by monosodium glutamate in humans. Physiol Behav 93:958–966PubMedCrossRef

Titel: Effect of platinum-containing chemotherapy on olfactory, gustatory, and hearing function in ovarian cancer patients
verfasst von: Silke Steinbach
Walter Hundt
Barbara Schmalfeldt
Christina Böhner
Sabina Berktold
Petra Wolf
Nadia Harbeck
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 2/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2307-5

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