Introduction
Methods
Study population
Statistical analysis
Results
Characteristics
Unadjusted analysis | Propensity score matching | |||||
---|---|---|---|---|---|---|
Non-RT = 429 | RT = 154 | p value | Non-RT = 154 | RT = 154 | p value | |
Age | 1.000 | 0.731 | ||||
< 50 | 197 (45.9%) | 71 (46.1%) | 67 (43.5%) | 71 (46.1%) | ||
≥ 50 | 232 (54.1%) | 83 (53.9%) | 87 (56.5%) | 83 (53.9%) | ||
Race | 0.311 | 0.803 | ||||
White | 298 (69.5%) | 98 (63.6%) | 97 (63.0%) | 98 (63.6%) | ||
Black | 51 (11.9%) | 25 (16.2%) | 22 (14.3%) | 25 (16.2%) | ||
Others | 80 (18.6%) | 31 (20.1%) | 35 (22.7%) | 31 (20.1%) | ||
Marital status | 0.203 | 1.000 | ||||
Married | 198 (46.2%) | 72 (46.8%) | 73 (47.4%) | 72 (46.8%) | ||
Unmarried | 200 (46.6%) | 77 (50.0%) | 77 (50.0%) | 77 (50.0%) | ||
Unknown | 31 (7.23%) | 5 (3.25%) | 4 (2.60%) | 5 (3.25%) | ||
Tumor grade | 0.003 | 0.984 | ||||
G1 | 39 (9.09%) | 10 (6.49%) | 11 (7.14%) | 10 (6.49%) | ||
G2 | 40 (9.32%) | 6 (3.90%) | 6 (3.90%) | 6 (3.90%) | ||
G3 | 54 (12.6%) | 35 (22.7%) | 38 (24.7%) | 35 (22.7%) | ||
G4 | 43 (10.0%) | 23 (14.9%) | 20 (13.0%) | 23 (14.9%) | ||
Unknown | 253 (59.0%) | 80 (51.9%) | 79 (51.3%) | 80 (51.9%) | ||
Laterality | 0.355 | 1.000 | ||||
Left | 194 (45.2%) | 77 (50.0%) | 76 (49.4%) | 77 (50.0%) | ||
Right | 235 (54.8%) | 77 (50.0%) | 78 (50.6%) | 77 (50.0%) | ||
Tumor stage | 1.000 | 1.000 | ||||
T3 | 383 (89.3%) | 137 (89.0%) | 137 (89.0%) | 137 (89.0%) | ||
T4 | 46 (10.7%) | 17 (11.0%) | 17 (11.0%) | 17 (11.0%) | ||
Lymph node | 0.116 | 1.000 | ||||
Negative | 422 (98.4%) | 148 (96.1%) | 149 (96.8%) | 148 (96.1%) | ||
Positive | 7 (1.63%) | 6 (3.90%) | 5 (3.25%) | 6 (3.90%) | ||
Distant metastasis | 0.189 | 0.571 | ||||
Negative | 418 (97.4%) | 146 (94.8%) | 149 (96.8%) | 146 (94.8%) | ||
Positive | 11 (2.56%) | 8 (5.19%) | 5 (3.25%) | 8 (5.19%) | ||
Surgery of primary site | 0.387 | 0.682 | ||||
No surgery | 4 (0.93%) | 1 (0.65%) | 1 (0.65%) | 1 (0.65%) | ||
BCS | 150 (35.0%) | 45 (29.2%) | 37 (24.0%) | 45 (29.2%) | ||
Mastectomy | 275 (64.1%) | 108 (70.1%) | 116 (75.3%) | 108 (70.1%) | ||
Chemotherapy | 0.007 | 0.524 | ||||
No | 415 (96.7%) | 140 (90.9%) | 144 (93.5%) | 140 (90.9%) | ||
Yes | 14 (3.26%) | 14 (9.09%) | 10 (6.49%) | 14 (9.09%) | ||
Local lymphatic biopsy | 0.043 | 1.000 | ||||
No | 294 (68.5%) | 91 (59.1%) | 90 (58.4%) | 91 (59.1%) | ||
Yes | 135 (31.5%) | 63 (40.9%) | 64 (41.6%) | 63 (40.9%) |
Survival analysis of radiotherapy
COX regression analysis
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Age | ||||
< 50 | 1 | 1 | ||
≥ 50 | 1.29 (0.89, 1.86) | 0.177 | 1.30 (0.878, 1.93) | 0.189 |
Race | ||||
White | 1 | 1 | ||
Black | 1.26 (0.76, 2.08) | 0.368 | 1.12 (0.68, 2.05) | 0.553 |
Other | 1.07 (0.67, 1.71) | 0.761 | 0.88 (0.52, 1.48) | 0.635 |
Marital status | ||||
Married | 1 | 1 | ||
Unmarried | 1.08 (0.75, 1.57) | 0.669 | 0.913 (0.614, 1.359) | 0.655 |
Unknown | 0.86 (0.37, 1.99) | 0.721 | 0.915 (0.386, 2.167) | 0.840 |
Tumor grade | ||||
G1 | 1 | 1 | ||
G2 | 1.07 (0.34, 3.30) | 0.913 | 1.06 (0.34, 3.32) | 0.920 |
G3 | 2.43 (0.99, 5.97) | 0.053 | 1.41 (0.56, 3.55) | 0.470 |
G4 | 3.32 (1.35, 8.19) | 0.009 | 2.21 (0.87, 5.59) | 0.095 |
Unknown | 1.66 (0.72, 3.84) | 0.237 | 1.25 (0.53, 2.93) | 0.611 |
Laterality | ||||
Left | 1 | 1 | ||
Right | 0.86 (0.60, 1.24) | 0.429 | 0.91 (0.62, 1.34) | 0.644 |
Tumor stage | ||||
T3 | 1 | 1 | ||
T4 | 3.38 (2.21, 5.18) | < 0.001 | 1.58 (0.96, 2.60) | 0.070 |
Lymph node | ||||
Negative | 1 | 1 | ||
Positive | 3.23 (1.42, 7.35) | 0.005 | 0.970 (0.36, 2.60) | 0.951 |
Distant metastasis | ||||
Negative | 1 | 1 | ||
Positive | 0.03 (0.02, 0.06) | < 0.001 | 0.071 (0.034, 0.147) | < 0.001 |
Surgery of primary site | ||||
No surgery | 1 | 1 | ||
BCS | 0.03 (0.01, 0.08) | < 0.001 | 0.059 (0.018, 0.2) | < 0.001 |
Mastectomy | 0.08 (0.03, 0.20) | < 0.001 | 0.119 (0.038, 0.368) | < 0.001 |
Radiotherapy | ||||
No | 1 | 1 | ||
Yes | 1.38 (0.94, 2.03) | 0.100 | 1.03 (0.68, 1.56) | 0.877 |
Chemotherapy | ||||
No | 1 | 1 | ||
Yes | 4.45 (2.58, 7.66) | < 0.001 | 1.419 (0.721, 2.794) | 0.311 |
Local lymphatic biopsy | ||||
No | 1 | 1 | ||
Yes | 1.46 (1.01, 2.10) | 0.045 | 1.117 (0.753, 1.656) | 0.582 |
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
HR (95%CI) | p | HR (95%CI) | p | |
Age | ||||
< 50 | 1 | 1 | ||
≥ 50 | 1.82 (1.33, 2.48) | < 0.001 | 1.799 (1.292, 2.504) | < 0.001 |
Race | ||||
White | 1 | 1 | ||
Black | 1.17 (0.77, 1.78) | 0.454 | 1.202 (0.767, 1.884) | 0.423 |
Others | 1.03 (0.71, 1.51) | 0.868 | 0.895 (0.59, 1.36) | 0.602 |
Marital status | ||||
Married | 1 | 1 | ||
Unmarried | 1.24 (0.91, 1.68) | 0.172 | 1.082 (0.782, 1.496) | 0.633 |
Unknown | 1.23 (0.67, 2.26) | 0.509 | 1.182 (0.633, 2.210) | 0.599 |
Tumor grade | ||||
G1 | 1 | 1 | ||
G2 | 0.91 (0.42, 2.00) | 0.817 | 0.903 (0.408, 1.996) | 0.800 |
G3 | 1.73 (0.91, 3.27) | 0.092 | 1.09311 (0.56402, 2.1186) | 0.792 |
G4 | 1.82 (0.94, 3.53) | 0.076 | 1.24171 (0.62583, 2.4637) | 0.536 |
Unknown | 1.18 (0.66, 2.11) | 0.575 | 0.944 (0.522, 1.709) | 0.850 |
Laterality | ||||
Left | 1 | 1 | ||
Right | 0.89 (0.66, 1.20) | 0.443 | 0.969 (0.709, 1.323) | 0.842 |
Tumor stage | ||||
T3 | 1 | 1 | ||
T4 | 2.97 (2.06, 4.29) | < 0.001 | 1.445 (0.953, 2.189) | 0.083 |
Lymph node | ||||
Negative | 1 | 1 | ||
Positive | 2.93 (1.44, 5.98) | 0.003 | 1.238 (0.547, 2.803) | 0.6084 |
Distant metastasis | ||||
Negative | 1 | 1 | ||
Positive | 0.03 (0.02, 0.06) | < 0.001 | 0.079 (0.041, 0.151) | < 0.001 |
Surgery of primary site | ||||
No surgery | 1 | 1 | ||
BCS | 0.04 (0.01, 0.09) | < 0.001 | 0.051 (0.017, 0.154) | < 0.001 |
Mastectomy | 0.10 (0.04, 0.24) | < 0.001 | 0.106 (0.037, 0.302) | < 0.001 |
Radiotherapy | ||||
No | 1 | 1 | ||
Yes | 1.16 (0.84, 1.61) | 0.373 | 0.899 (0.634, 1.276) | 0.554 |
Chemotherapy | ||||
No | 1 | 1 | ||
Yes | 4.44 (2.81, 7.02) | < 0.001 | 1.921 (1.090, 3.387) | 0.424 |
Local lymphatic biopsy | ||||
No | 1 | 1 | ||
Yes | 1.59 (1.18, 2.14) | 0.002 | 1.227 (0.893, 1.686) | 0.208 |