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Supportive Care in Cancer
Erschienen in:

06.04.2019 | Review Article

Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis

verfasst von: Hongxia Hua, Xinyi Xu, Yu Tang, Ziqi Ren, Qin Xu, Li Chen

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2019

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Abstract

Background

The effect of sarcopenia on digestive carcinoma surgery outcomes is controversial. We aimed to assess the effect of sarcopenia defined by the European Working Group on Sarcopenia in Older People (EWGSOP) or the Asian Working Group for Sarcopenia (AWGS) on outcomes following digestive carcinoma surgery.

Methods

Eligible studies were searched from PubMed, EMBASE and other databases from inception to April 2018. We conducted a meta-analysis to estimate the risk ratios or mean differences of outcomes in the sarcopenia group versus the non-sarcopenia group. Stratified analyses and sensitivity analyses were performed.

Results

We included 11 cohort studies, with a sarcopenia prevalence ranging from 11.6 to 33.0%. Sarcopenia was associated with an increased risk of total complications (RR = 1.87, P < 0.00001), major complications (RR = 2.45, P = 0.002), re-admissions (RR = 2.53,P < 0.0001), infections (RR = 2.23, P = 0.09), severe infections (RR = 2.96, P = 0.04), 30-day mortality (RR = 3.36, P = 0.001), longer hospital stay (MD = 4.61, P = 0.001) and increased hospitalization expenditures (SMD = 0.25, P = 0.02). Sarcopenia differentially affected outcomes when stratified, and the results were stable.

Conclusions

Sarcopenia defined by the EWGSOP or AWGS Consensus was a high-risk factor for digestive carcinoma surgery outcomes. Different tumour site and muscle mass measurements are the sources of heterogeneity. More high-quality studies are needed.
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Metadaten
Titel
Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis
verfasst von
Hongxia Hua
Xinyi Xu
Yu Tang
Ziqi Ren
Qin Xu
Li Chen
Publikationsdatum
06.04.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 7/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-019-04767-4

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