nach oben

Erschienen in:

01.01.2013 | Original Article

Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients

verfasst von: S. Gamsjaeger, B. Hofstetter, E. Zwettler, R. Recker, J. A. Gasser, E. F. Eriksen, K. Klaushofer, E. P. Paschalis

Erschienen in: Osteoporosis International | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Summary

Once-yearly administration of intravenous zoledronic acid for 3 years in humans affects the kinetics of matrix filling in by mineral, independent of bone turnover.

Introduction

Yearly 5-mg infusions of zoledronic acid (ZOL) for 3 years have shown pronounced antifracture efficacy. The purpose of the present study was to test whether ZOL affects the kinetics of forming bone material properties maturation.

Methods

Iliac crest biopsies from the HORIZON-PFT clinical trial were analyzed by Raman microspectroscopy in actively bone-forming surfaces as a function of tissue age in trabecular and osteonal bone, to determine ZOL’s effect on bone material quality indices maturation kinetics.

Results

Mineral/matrix ratio increased in both groups as a function of tissue age, at both osteonal- and trabecular-forming surfaces; ZOL exhibiting the greatest increase in the trabecular surfaces only. The proteoglycan content showed a dependency on tissue age in both trabecular and osteonal surfaces, with ZOL exhibiting lower values in the tissue age 8–22 days in the trabecular surfaces. Mineral crystallinity (crystallite length and thickness) showed a dependence on tissue age, with ZOL exhibiting lower crystallite length compared with placebo only in the 8- to 22-day-old tissue at trabecular surfaces, while crystal thickness was lower in the 1- to 5-day-old tissue at both osteonal and trabecular surfaces.

Conclusions

The results of the present study suggest that once-yearly administration of intravenous ZOL for 3 years in humans does not exert any adverse effects on the evolution of bone material properties at actively forming osteonal and trabecular surfaces, while it may have a beneficial effect on the progression of the mineral-to-matrix ratio and mineral maturity bone quality indices.

Nancollas GH, Tang R, Phipps RJ, Henneman Z, Gulde S, Wu W, Mangood A, Russell RG, Ebetino FH (2006) Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone 38:617–627PubMedCrossRef

Cai K, Frant M, Bossert J, Hildebrand G, Liefeith K, Jandt KD (2006) Surface functionalized titanium thin films: zeta-potential, protein adsorption and cell proliferation. Colloids Surf B Biointerfaces 50:1–8PubMedCrossRef

Chen L, Mccrate JM, Lee JC, Li H (2011) The role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells. Nanotechnology 22:105708PubMedCrossRef

Nebe B, Finke B, Luthen F, Bergemann C, Schroder K, Rychly J, Liefeith K, Ohl A (2007) Improved initial osteoblast functions on amino-functionalized titanium surfaces. Biomol Eng 24:447–454PubMedCrossRef

Shahryari A, Azari F, Vali H, Omanovic S (2009) The positive influence of electrochemical cyclic potentiodynamic passivation (cpp) of a ss316ls surface on its response to fibronectin and pre-osteoblasts. Phys Chem Chem Phys 11:6218–6224PubMedCrossRef

Smeets R, Kolk A, Gerressen M, Driemel O, Maciejewski O, Hermanns-Sachweh B, Riediger D, Stein JM (2009) A new biphasic osteoinductive calcium composite material with a negative zeta potential for bone augmentation. Head Face Med 5:13PubMedCrossRef

Smith IO, Baumann MJ, Mccabe LR (2004) Electrostatic interactions as a predictor for osteoblast attachment to biomaterials. J Biomed Mater Res A 70:436–441PubMedCrossRef

Smith IO, Baumann MJ, Obadia L, Bouler JM (2004) Surface potential and osteoblast attraction to calcium phosphate compounds is affected by selected alkaline hydrolysis processing. J Mater Sci Mater Med 15:841–846PubMedCrossRef

Zhang Y, Yang M, Portney NG, Cui D, Budak G, Ozbay E, Ozkan M, Ozkan CS (2008) Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells. Biomed Microdevices 10:321–328PubMedCrossRef

10.

Fratzl P, Gupta H, Paschalis E, Roschger P (2004) Structure and mechanical quality of the collagen–mineral nano-composite in bone. J Mater Chem 14:2115–2123CrossRef

11.

Hofstetter B, Gamsjaeger S, Phipps R, Recker R, Ebetino F, Klaushofer K, Paschalis E (2012) Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces. J Bone Miner Res 27:995–1003PubMedCrossRef

12.

Fuchs RK, Faillace ME, Allen MR, Phipps RJ, Miller LM, Burr DB (2011) Bisphosphonates do not alter the rate of secondary mineralization. Bone 49:701–705PubMedCrossRef

13.

Paschalis EP, Tatakis DN, Robins S, Fratzl P, Manjubala I, Zoehrer R, Gamsjaeger S, Buchinger B, Roschger A, Phipps R, Boskey AL, Dall’Ara E, Varga P, Zysset P, Klaushofer K, Roschger P (2011) Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral. Bone 49:1232–1241PubMedCrossRef

14.

Recker RR, Delmas PD, Halse J, Reid IR, Boonen S, Garcia-Hernandez PA, Supronik J, Lewiecki EM, Ochoa L, Miller P, Hu H, Mesenbrink P, Hartl F, Gasser J, Eriksen EF (2008) Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure. J Bone Miner Res 23:6–16PubMedCrossRef

15.

Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriksen EF, Cummings SR (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809–1822PubMedCrossRef

16.

Gamsjaeger S, Buchinger B, Zwettler E, Recker R, Black D, Gasser JA, Eriksen EF, Klaushofer K, Paschalis EP (2011) Bone material properties in actively bone-forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once-yearly zoledronic acid. J Bone Miner Res 26:12–18PubMedCrossRef

17.

Gamsjäger S, Kazanci M, Paschalis E, Fratzl P (2009) Raman spectroscopy for soft matter applications. In: Amer M (ed) Raman application in bone imaging. Wiley, Hoboken, pp 227–269

18.

Juang C, Finzi L, Bustamante C (1988) Design and application of a computer-controlled confocal scanning differential polarization microscope. Rev Sci Instrum 59:2399–2408CrossRef

19.

Lieber CA, Mahadevan-Jansen A (2003) Automated method for subtraction of fluorescence from biological Raman spectra. Appl Spectrosc 57:1363–1367PubMedCrossRef

20.

Gamsjaeger S, Masic A, Roschger P, Kazanci M, Dunlop JW, Klaushofer K, Paschalis EP, Fratzl P (2010) Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy. Bone 47:392–399PubMedCrossRef

21.

Quiles F, Balandier JY, Capizzi-Banas S (2006) In situ characterisation of a microorganism surface by Raman microspectroscopy: the shell of Ascaris eggs. Anal Bioanal Chem 386:249–255PubMedCrossRef

22.

Ellis R, Green E, Winlove CP (2009) Structural analysis of glycosaminoglycans and proteoglycans by means of Raman microspectrometry. Connect Tissue Res 50:29–36PubMedCrossRef

23.

Koljenovic S, Bakker Schut TC, Van Meerbeeck JP, Maat AP, Burgers SA, Zondervan PE, Kros JM, Puppels GJ (2004) Raman microspectroscopic mapping studies of human bronchial tissue. J Biomed Opt 9:1187–1197PubMedCrossRef

24.

Rieppo L, Rieppo J, Jurvelin JS, Saarakkala S (2012) Fourier transform infrared spectroscopic imaging and multivariate regression for prediction of proteoglycan content of articular cartilage. PLoS One 7:E32344PubMedCrossRef

25.

Kazanci M, Fratzl P, Klaushofer K, Paschalis EP (2006) Complementary information on in vitro conversion of amorphous (precursor) calcium phosphate to hydroxyapatite from Raman microspectroscopy and wide-angle X-ray scattering. Calcif Tissue Int 79:354–359PubMedCrossRef

26.

Bullough P (1992) Atlas of orthopaedic pathology. Gower, New York

27.

Einhorn TA (1996) The bone organ system: form and function. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, New York

28.

Boskey AL, Coleman R (2010) Aging and bone. J Dent Res 89:1333–1348PubMedCrossRef

29.

Paschalis EP (2009) Fourier transform infrared analysis and bone. Osteoporos Int 20:1043–1047PubMedCrossRef

30.

Boskey AL, Pleshko N, Doty SB, Mendelsohn R (1992) Applications of Fourier transform infrared (FT-IR) microscopy to the study of mineralization in bone and cartilage. Cells And Materials 2:209–220

31.

Donnelly E, Chen DX, Boskey AL, Baker SP, Van Der Meulen MC (2010) Contribution of mineral to bone structural behavior and tissue mechanical properties. Calcif Tissue Int 87:450–460PubMedCrossRef

32.

Ebetino F, Cornish J, Phipps R, Keck B, Reid I, Callon K (2010) Relative uptake of risedronate in trabecular and cortical bone. Bone 46:70CrossRef

33.

Boskey AL, Spevak L, Doty SB, Rosenberg L (1997) Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel. Calcif Tissue Int 61:298–305PubMedCrossRef

34.

Mochida Y, Duarte WR, Tanzawa H, Paschalis EP, Yamauchi M (2003) Decorin modulates matrix mineralization in vitro. Biochem Biophys Res Commun 305:6–9PubMedCrossRef

35.

Roschger P, Paschalis EP, Fratzl P, Klaushofer K (2008) Bone mineralization density distribution in health and disease. Bone 42:456–466PubMedCrossRef

36.

Grzesik WJ, Frazier CR, Shapiro JR, Sponseller PD, Robey PG, Fedarko NS (2002) Age-related changes in human bone proteoglycan structure. Impact of osteogenesis imperfecta. J Biol Chem 277:43638–43647PubMedCrossRef

37.

Boskey AL, Dicarlo E, Paschalis E, West P, Mendelsohn R (2005) Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int 16:2031–2038PubMedCrossRef

38.

Paschalis EP, Betts F, Dicarlo E, Mendelsohn R, Boskey AL (1997) FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone. Calcif Tissue Int 61:487–492PubMedCrossRef

39.

Jager I, Fratzl P (2000) Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles. Biophys J 79:1737–1746PubMedCrossRef

40.

Farlay D, Panczer G, Rey C, Delmas PD, Boivin G (2010) Mineral maturity and crystallinity index are distinct characteristics of bone mineral. J Bone Miner Metab 28:433–445PubMedCrossRef

41.

Gadaleta SJ, Paschalis EP, Betts F, Mendelsohn R, Boskey AL (1996) Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: new correlations between X-ray diffraction and infrared data. Calcif Tissue Int 58:9–16PubMedCrossRef

42.

Paschalis EP, Dicarlo E, Betts F, Sherman P, Mendelsohn R, Boskey AL (1996) FTIR microspectroscopic analysis of human osteonal bone. Calcif Tissue Int 59:480–487PubMed

43.

Rey C, Shimizu M, Collins B, Glimcher MJ (1991) Resolution-enhanced Fourier transform infrared spectroscopy study of the environment of phosphate ion in the early deposits of a solid phase of calcium phosphate in bone and enamel and their evolution with age: 2. Investigations in the nu3po4 domain. Calcif Tissue Int 49:383–388PubMedCrossRef

44.

Henneman ZJ, Nancollas GH, Ebetino FH, Russell RG, Phipps RJ (2008) Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro. J Biomed Mater Res A 85:993–1000PubMed

45.

Fratzl P, Roschger P, Eschberger J, Abendroth B, Klaushofer K (1994) Abnormal bone mineralization after fluoride treatment in osteoporosis: a small-angle X-ray-scattering study. J Bone Miner Res 9:1541–1549PubMedCrossRef

46.

Paschalis EP, Mendelsohn R, Boskey AL (2011) Infrared assessment of bone quality: a review. Clin Orthop Relat Res 469:2170–2178PubMedCrossRef

Titel: Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients
verfasst von: S. Gamsjaeger
B. Hofstetter
E. Zwettler
R. Recker
J. A. Gasser
E. F. Eriksen
K. Klaushofer
E. P. Paschalis
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 1/2013
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-012-2202-8

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

25.04.2024 | Hypertonie | Nachrichten

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients

Abstract

Summary

Introduction

Methods

Results

Conclusions

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Update Orthopädie und Unfallchirurgie

Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

Defining the epidemiology of bisphosphonate-associated osteonecrosis of the jaw: prior work and current challenges

Non-hip, non-spine fractures drive healthcare utilization following a fracture: the Global Longitudinal Study of Osteoporosis in Women (GLOW)

QCT bone mineral density responses to 1 year of oral bisphosphonate after total knee replacement for knee osteoarthritis

Effect of oral monthly ibandronate on bone microarchitecture in women with osteopenia—a randomized placebo-controlled trial

Ten-year hip fracture incidence rate trends in a large California population, 1997–2006

The effect of treatments for osteoporosis on mortality

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Update Orthopädie und Unfallchirurgie